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Gene · 640

BLK: BLK proto-oncogene, Src family tyrosine kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BLK: BLK proto-oncogene, Src family tyrosine kinase. Genes, record 640. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/640

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Gene

Symbol
BLK
HGNC
Name
BLK proto-oncogene, Src family tyrosine kinase
HGNC
NCBI Gene ID
640
NCBI Gene
HGNC ID
HGNC:1057
HGNC
Ensembl
ENSG00000136573
NCBI Gene
Aliases
MGC10442, MODY11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51451Tyrosine-protein kinase Blk5050Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438564P51451Espacenet
EP 4641202 A22025-10-294497P51451Espacenet
JP 2025062604 A2025-04-149203P51451Espacenet
KR 1020250017231 A2025-02-044497P51451Espacenet
US 11685954 B22023-06-27200P51451Espacenet
US 11446398 B22022-09-209203P51451Espacenet
JP 2022524081 A2022-04-27112174P51451Espacenet
US 11078247 B22021-08-031168P51451Espacenet
US 10918740 B22021-02-167057P51451Espacenet
US 10869935 B22020-12-227057P51451Espacenet

1 to 10 of 31

See all 31 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DASATINIB ANHYDROUSCHEMBL1421SRC inhibitorINHIBITORChEMBL
ENMD-981693CHEMBL52885SRC inhibitorINHIBITORChEMBL
ILORASERTIBCHEMBL1980297SRC inhibitorINHIBITORChEMBL
TG100-801CHEMBL403989SRC inhibitorINHIBITORChEMBL
XL-228CHEMBL3545085SRC inhibitorINHIBITORChEMBL

Trials225

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06390319DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06355037DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06336395DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06124157DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT06055621DASATINIB ANHYDROUSPHASE2ClinicalTrials.gov
NCT05993949DASATINIB ANHYDROUSPHASE1ClinicalTrials.gov
NCT05751044DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05559008DASATINIB ANHYDROUSPHASE1/PHASE2ClinicalTrials.gov
NCT05432518DASATINIB ANHYDROUSEARLY_PHASE1ClinicalTrials.gov
NCT05422885DASATINIB ANHYDROUSPHASE1/PHASE22025-03-17ClinicalTrials.gov

1 to 10 of 225

See all 225 trials

NIH grants1,820

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBLK papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
R01AI024717Genetic Linkage in Lupus132025
P30CA008748Cancer Center Support Grant112025
ZIAES101074Environmental/genetic Risk Factors and Pathogenesis of Autoimmune Disease82025
U54GM104938Oklahoma Shared Clinical and Translational Resources72025
P30CA016058Cancer Center Support Grant52025
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state52025
R01CA157644Central tolerance mechanisms in B-cell malignancies52025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025

1 to 10 of 1,820Source NIH's project files

See all 1,820 nih grants

Papers2,339

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A multi-ancestry genome-wide association study of dry eye disease and systemic comorbidities.EBioMedicine202642790339PubTator, text miningPubMed
Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.Int J Mol Sci202642653386PubTator, text miningPubMed
Genome-wide meta-analysis with 1,590,596 individuals identifies 12 novel risk loci for systemic lupus erythematosus.Mamm Genome202642581184PubTator, text miningPubMed
Thymic Stromal Lymphopoietin-Driven B-Cell Hyperactivation Impairs Intestinal Epithelial Homeostasis Predisposing to Enterocolitis in Hirschsprung Disease.Cell Mol Gastroenterol Hepatol202642463013PubTator, text miningPubMed
Uncovering alterations in cancer epigenetics via trans-dimensional Markov chain Monte Carlo and hidden Markov models.J R Stat Soc Ser C Appl Stat202642389235PubTator, text miningPubMed
Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis.ACR Open Rheumatol202642376974PubTator, text miningPubMed
Peripheral B cell immune dysregulation genetically contributes to stage-dependent neuroinflammation and identifies priority therapeutic targets in Parkinson's disease: a computational integration of Mendelian randomization and single-cell transcriptomics.
Front Med (Lausanne)202642344507PubTator, text miningPubMed
Identification and validation of BLK and OSBPL10 as diagnostic and prognostic biomarkers for nasopharyngeal carcinoma through machine learning algorithms.Sci Rep202642336993PubTator, text miningPubMed
Emphysema Shapes a Pro-Inflammatory Immune Microenvironment in Pulmonary Adenocarcinoma: A Pilot Immune Transcriptomic Profiling Study.Int J Mol Sci202642123542PubTator, text miningPubMed
BLK suppresses melanoma progression and improves prognosis via pyroptosis regulation.Sci Rep202642067550PubTator, text miningPubMed

1 to 10 of 2,339

See all 2,339 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

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