Gene · 640
BLK: BLK proto-oncogene, Src family tyrosine kinase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BLK: BLK proto-oncogene, Src family tyrosine kinase. Genes, record 640. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/640
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51451 | Tyrosine-protein kinase Blk | 505 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38564 | P51451 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4497 | P51451 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 9203 | P51451 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4497 | P51451 | Espacenet |
| US 11685954 B2 | 2023-06-27 | 200 | P51451 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 9203 | P51451 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 112174 | P51451 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 1168 | P51451 | Espacenet |
| US 10918740 B2 | 2021-02-16 | 7057 | P51451 | Espacenet |
| US 10869935 B2 | 2020-12-22 | 7057 | P51451 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials225
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06390319 | DASATINIB ANHYDROUS | PHASE2 | ClinicalTrials.gov | |
| NCT06355037 | DASATINIB ANHYDROUS | PHASE2 | ClinicalTrials.gov | |
| NCT06336395 | DASATINIB ANHYDROUS | PHASE2 | ClinicalTrials.gov | |
| NCT06124157 | DASATINIB ANHYDROUS | PHASE2 | ClinicalTrials.gov | |
| NCT06055621 | DASATINIB ANHYDROUS | PHASE2 | ClinicalTrials.gov | |
| NCT05993949 | DASATINIB ANHYDROUS | PHASE1 | ClinicalTrials.gov | |
| NCT05751044 | DASATINIB ANHYDROUS | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05559008 | DASATINIB ANHYDROUS | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05432518 | DASATINIB ANHYDROUS | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT05422885 | DASATINIB ANHYDROUS | PHASE1/PHASE2 | 2025-03-17 | ClinicalTrials.gov |
1 to 10 of 225
See all 225 trialsNIH grants1,820
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BLK papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 17 | 2025 |
| R01AI024717 | Genetic Linkage in Lupus | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| ZIAES101074 | Environmental/genetic Risk Factors and Pathogenesis of Autoimmune Disease | 8 | 2025 |
| U54GM104938 | Oklahoma Shared Clinical and Translational Resources | 7 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
| R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 5 | 2025 |
| R01CA157644 | Central tolerance mechanisms in B-cell malignancies | 5 | 2025 |
| P30DK042086 | Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) | 4 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 4 | 2025 |
1 to 10 of 1,820Source NIH's project files
See all 1,820 nih grantsPapers2,339
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A multi-ancestry genome-wide association study of dry eye disease and systemic comorbidities. | EBioMedicine | 2026 | 42790339 | PubTator, text mining | PubMed |
| Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa. | Int J Mol Sci | 2026 | 42653386 | PubTator, text mining | PubMed |
| Genome-wide meta-analysis with 1,590,596 individuals identifies 12 novel risk loci for systemic lupus erythematosus. | Mamm Genome | 2026 | 42581184 | PubTator, text mining | PubMed |
| Thymic Stromal Lymphopoietin-Driven B-Cell Hyperactivation Impairs Intestinal Epithelial Homeostasis Predisposing to Enterocolitis in Hirschsprung Disease. | Cell Mol Gastroenterol Hepatol | 2026 | 42463013 | PubTator, text mining | PubMed |
| Uncovering alterations in cancer epigenetics via trans-dimensional Markov chain Monte Carlo and hidden Markov models. | J R Stat Soc Ser C Appl Stat | 2026 | 42389235 | PubTator, text mining | PubMed |
| Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis. | ACR Open Rheumatol | 2026 | 42376974 | PubTator, text mining | PubMed |
Peripheral B cell immune dysregulation genetically contributes to stage-dependent neuroinflammation and identifies priority therapeutic targets in Parkinson's disease: a computational integration of Mendelian randomization and single-cell transcriptomics. | Front Med (Lausanne) | 2026 | 42344507 | PubTator, text mining | PubMed |
| Identification and validation of BLK and OSBPL10 as diagnostic and prognostic biomarkers for nasopharyngeal carcinoma through machine learning algorithms. | Sci Rep | 2026 | 42336993 | PubTator, text mining | PubMed |
| Emphysema Shapes a Pro-Inflammatory Immune Microenvironment in Pulmonary Adenocarcinoma: A Pilot Immune Transcriptomic Profiling Study. | Int J Mol Sci | 2026 | 42123542 | PubTator, text mining | PubMed |
| BLK suppresses melanoma progression and improves prognosis via pyroptosis regulation. | Sci Rep | 2026 | 42067550 | PubTator, text mining | PubMed |
1 to 10 of 2,339
See all 2,339 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/640
GET https://conductscience.org/api/genes/v1/640/patents?page=2