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Gene · 64109

CRLF2: cytokine receptor like factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CRLF2: cytokine receptor like factor 2. Genes, record 64109. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64109

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Gene

Symbol
CRLF2
HGNC
Name
cytokine receptor like factor 2
HGNC
NCBI Gene ID
64109
NCBI Gene
HGNC ID
HGNC:14281
HGNC
Ensembl
ENSG00000205755, ENSG00000292363
NCBI Gene
Aliases
CRL2, CRLF2Y, TSLPR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HC73Cytokine receptor-like factor 23712Ensembl, GeneID, HGNC

Source UniProt

Patents99

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4791773 A12026-08-1970Q9HC73Espacenet
EP 4791783 A12026-08-1970Q9HC73Espacenet
EP 4791792 A12026-08-1970Q9HC73Espacenet
JP 2026094137 A2026-06-094Q9HC73Espacenet
JP 2026000906 A2026-01-0665Q9HC73Espacenet
EP 4650780 A22025-11-1910471Q9HC73Espacenet
JP 2025532685 A2025-10-0136Q9HC73Espacenet
JP 2025529142 A2025-09-041123Q9HC73Espacenet
EP 4590719 A12025-07-3036Q9HC73Espacenet
US 12371689 B22025-07-291123Q9HC73Espacenet

1 to 10 of 99

See all 99 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,341

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCRLF2 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)592025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement262025
U10CA180899Children's Oncology Group Statistics and Data Center232025
R35CA197695Translating genomic discoveries to improved outcomes for high risk acute leukemia212025
P30CA008748Cancer Center Support Grant202025
P30CA016672Cancer Center Support Grant172025
ZIAHL005409IL-2 Family Cytokines and their Receptors--Biology of the IL-7/TSLP Systems142025
U19AI070235Epithelial Genes in Allergic Inflammation122025
T32CA128583Research Training in Childhood Cancer112025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102025

1 to 10 of 1,341Source NIH's project files

See all 1,341 nih grants

Papers2,232

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia.Haematologica202642687815PubTator, text miningPubMed
Comprehensive genetic characterization of adult BCR::ABL1-negative B-ALL by optical genome mapping and targeted NGS.Blood Adv202642664485PubTator, text miningPubMed
Phosgene inhalation injury in mice: Modeling human pathophysiology, biomarker discovery, and therapeutic target identification.Toxicol Appl Pharmacol202642575345PubTator, text miningPubMed
Genomic profiling of Mexican patients with B-cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants.J Pathol Clin Res202642552995PubTator, text miningPubMed
TSLP impairs mucociliary transport by inhibiting JAK signaling in both central and peripheral airways.Pflugers Arch202642547653PubTator, text miningPubMed
BACH1 meets its match: Heme licenses BACH1 destruction to tune ferroptosis.Cell Chem Biol202642462695PubTator, text miningPubMed
[Clinical features of CRLF2 overexpression in pediatric B-cell acute lymphoblastic leukemia].Zhongguo Dang Dai Er Ke Za Zhi202642457326PubTator, text miningPubMed
Clinical features and initial treatment outcomes of pediatric B-cell acute lymphoblastic leukemia with P2RY8::CRLF2 fusion positivity: a case series.Transl Pediatr202642433937PubTator, text miningPubMed
Native Mass Spectrometry Analysis of Cullin-RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation.Anal Chem202642378227PubTator, text miningPubMed
Combination of p-STAT5, CRLF2 and copy number alterations as a potential indicator of a high-risk subgroup of acute lymphoblastic leukemia.Discov Oncol202642334675PubTator, text miningPubMed

1 to 10 of 2,232

See all 2,232 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/64109

GET https://conductscience.org/api/genes/v1/64109/patents?page=2