Gene · 64116
SLC39A8: solute carrier family 39 member 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC39A8: solute carrier family 39 member 8. Genes, record 64116. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64116
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9C0K1 | Metal cation symporter ZIP8 | 460 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents77
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4649176 A2 | 2025-11-19 | 4 | Q9C0K1 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7341 | Q9C0K1 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1088 | Q9C0K1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7287 | Q9C0K1 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4223 | Q9C0K1 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4223 | Q9C0K1 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1088 | Q9C0K1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7287 | Q9C0K1 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7341 | Q9C0K1 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 81672 | Q9C0K1 | Espacenet |
1 to 10 of 77
See all 77 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,743
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC39A8 papers | Newest fiscal year |
|---|---|---|---|
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 24 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 13 | 2025 |
| R01ES007331 | Mechanisms of Methylmercury Induced Neuronal Toxicity | 11 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 11 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 10 | 2025 |
| R01DK062370 | Identifying Genes for Type 2 Diabetes: FUSION | 8 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 7 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| R01DK075787 | Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum | 5 | 2025 |
1 to 10 of 1,743Source NIH's project files
See all 1,743 nih grantsPapers1,377
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis-Associated Redox Signaling and Trophoblast Behavior. | FASEB J | 2026 | 42803694 | PubTator, text mining | PubMed |
| Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects. | J Biol Chem | 2026 | 42710664 | PubTator, text mining | PubMed |
| Silencing of solute carrier family 39 member 8 exerts antitumor effects in glioma by inducing ferroptosis via the zinc-dependent CREB/GPX4 pathway. | Int Immunopharmacol | 2026 | 42667888 | PubTator, text mining | PubMed |
| Manganese transport, homeostasis, and neurotoxicity. | Physiol Rev | 2026 | 42568347 | PubTator, text mining | PubMed |
| Functional characterization of a novel ZIP8 variant causing impaired manganese homeostasis and congenital disorders of glycosylation. | Biometals | 2026 | 42484988 | PubTator, text mining | PubMed |
| Integrating Methylation Signature Modifications and Subtype Classification into a Prognostic Risk Model for Survival Prognosis and Predicting Immunotherapy Response in Colorectal Cancer. | Curr Med Chem | 2026 | 42458941 | PubTator, text mining | PubMed |
| Schizophrenia Genetic Liability Drives Chronic Disease Risk in Unaffected Individuals through Immune and Metabolic Pathways. | Psychother Psychosom | 2026 | 42371855 | PubTator, text mining | PubMed |
| Manganese: biology, physiology and role in disease. | Cell Discov | 2026 | 42303625 | PubTator, text mining | PubMed |
| Adalimumab Reprograms M1 Macrophages to Attenuate Th1/Th17 Responses in Behçet's Uveitis and Vogt-Koyanagi-Harada Syndrome. | Invest Ophthalmol Vis Sci | 2026 | 42227805 | PubTator, text mining | PubMed |
| Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects. | bioRxiv | 2026 | 42182434 | PubTator, text mining | PubMed |
1 to 10 of 1,377
See all 1,377 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/64116
GET https://conductscience.org/api/genes/v1/64116/patents?page=2