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Gene · 64116

SLC39A8: solute carrier family 39 member 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC39A8: solute carrier family 39 member 8. Genes, record 64116. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64116

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Gene

Symbol
SLC39A8
HGNC
Name
solute carrier family 39 member 8
HGNC
NCBI Gene ID
64116
NCBI Gene
HGNC ID
HGNC:20862
HGNC
Ensembl
ENSG00000138821
NCBI Gene
Aliases
BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP-8, ZIP8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9C0K1Metal cation symporter ZIP84600Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4649176 A22025-11-194Q9C0K1Espacenet
EP 4650780 A22025-11-197341Q9C0K1Espacenet
EP 4640849 A22025-10-291088Q9C0K1Espacenet
EP 4641201 A22025-10-297287Q9C0K1Espacenet
JP 2025529142 A2025-09-044223Q9C0K1Espacenet
US 12371689 B22025-07-294223Q9C0K1Espacenet
JP 2025519096 A2025-06-241088Q9C0K1Espacenet
JP 2025517969 A2025-06-127287Q9C0K1Espacenet
JP 2025517970 A2025-06-127341Q9C0K1Espacenet
US 11446398 B22022-09-2081672Q9C0K1Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,743

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC39A8 papersNewest fiscal year
R01ES010563Mechanisms of Manganese Neurotoxicity242025
P30DK063491Diabetes Research Center (DRC)132025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity112025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal112025
P30ES010126UNC Center for Environmental Health and Susceptibility102025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION82025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum52025

1 to 10 of 1,743Source NIH's project files

See all 1,743 nih grants

Papers1,377

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis-Associated Redox Signaling and Trophoblast Behavior.FASEB J202642803694PubTator, text miningPubMed
Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects.J Biol Chem202642710664PubTator, text miningPubMed
Silencing of solute carrier family 39 member 8 exerts antitumor effects in glioma by inducing ferroptosis via the zinc-dependent CREB/GPX4 pathway.Int Immunopharmacol202642667888PubTator, text miningPubMed
Manganese transport, homeostasis, and neurotoxicity.Physiol Rev202642568347PubTator, text miningPubMed
Functional characterization of a novel ZIP8 variant causing impaired manganese homeostasis and congenital disorders of glycosylation.Biometals202642484988PubTator, text miningPubMed
Integrating Methylation Signature Modifications and Subtype Classification into a Prognostic Risk Model for Survival Prognosis and Predicting Immunotherapy Response in Colorectal Cancer.Curr Med Chem202642458941PubTator, text miningPubMed
Schizophrenia Genetic Liability Drives Chronic Disease Risk in Unaffected Individuals through Immune and Metabolic Pathways.Psychother Psychosom202642371855PubTator, text miningPubMed
Manganese: biology, physiology and role in disease.Cell Discov202642303625PubTator, text miningPubMed
Adalimumab Reprograms M1 Macrophages to Attenuate Th1/Th17 Responses in Behçet's Uveitis and Vogt-Koyanagi-Harada Syndrome.Invest Ophthalmol Vis Sci202642227805PubTator, text miningPubMed
Functional screening of ZIP8 naturally occurring variants identifies pathogenic mutations and trafficking defects.bioRxiv202642182434PubTator, text miningPubMed

1 to 10 of 1,377

See all 1,377 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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