ConductScience.org, home

Library / Genes

NOD2: nucleotide binding oligomerization domain containing 2

1 protein, 58 patents, 2 drugs, 6 trials, 4,395 NIH grants and 9,807 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOD2HGNC
Namenucleotide binding oligomerization domain containing 2HGNC
NCBI Gene ID64127NCBI Gene
HGNC IDHGNC:5331HGNC
EnsemblENSG00000167207NCBI Gene
AliasesACUG, BLAU, BLAUS, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, YAOSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9HC29Nucleotide-binding oligomerization domain-containing protein 21,0400Ensembl, GeneID, HGNCUniProt

Patents 58

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456415Q9HC29Espacenet
EP 4640849 A22025-10-29522Q9HC29Espacenet
EP 4641201 A22025-10-293589Q9HC29Espacenet
JP 2025519096 A2025-06-24522Q9HC29Espacenet
JP 2025517969 A2025-06-123589Q9HC29Espacenet
US 11884978 B22024-01-30631Q9HC29Espacenet
US 11446398 B22022-09-2059041Q9HC29Espacenet
US 11408034 B22022-08-09520Q9HC29Espacenet
JP 2022532180 A2022-07-137Q9HC29Espacenet
JP 2022524081 A2022-04-27162012Q9HC29Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MIFAMURTIDECHEMBL2107354Nucleotide-binding oligomerization domain-containing protein 2 otherOTHERChEMBL
MIFAMURTIDE ACIDCHEMBL2111100Nucleotide-binding oligomerization domain-containing protein 2 otherOTHERChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04571229MIFAMURTIDEClinicalTrials.gov
NCT03643133MIFAMURTIDEPHASE2ClinicalTrials.gov
NCT02441309MIFAMURTIDEPHASE22019-09-13ClinicalTrials.gov
NCT01459484MIFAMURTIDEPHASE2ClinicalTrials.gov
NCT01194284MIFAMURTIDEClinicalTrials.gov
NCT00631631MIFAMURTIDEClinicalTrials.gov

NIH grants 4395

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital782,025NIH's project files
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations602,025NIH's project files
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes412,025NIH's project files
U01DK062432Montreal-Boston Collaborative GRC352,025NIH's project files
U01DK062423Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes332,025NIH's project files
U01DK062431IBD Gene Mapping by Clinical and Population Subset332,025NIH's project files
P30DK034989Yale Liver Center322,025NIH's project files
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)242,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology232,025NIH's project files
R01DK099097Functional outcomes of inflammatory bowel disease associated variants202,025NIH's project files

Papers 9807

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824032PubTator, text miningPubMed
42821198PubTator, text miningPubMed
42787422PubTator, text miningPubMed
42786248PubTator, text miningPubMed
42760420PubTator, text miningPubMed
42742958PubTator, text miningPubMed
42677679PubTator, text miningPubMed
42650137PubTator, text miningPubMed
42617271PubTator, text miningPubMed
42608607PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license