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Gene · 6421

SFPQ: splicing factor proline and glutamine rich

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SFPQ: splicing factor proline and glutamine rich. Genes, record 6421. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6421

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Gene

Symbol
SFPQ
HGNC
Name
splicing factor proline and glutamine rich
HGNC
NCBI Gene ID
6421
NCBI Gene
HGNC ID
HGNC:10774
HGNC
Ensembl
ENSG00000116560
NCBI Gene
Aliases
POMP100, PPP1R140, PSF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23246Splicing factor, proline- and glutamine-rich70713Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465342P23246Espacenet
EP 4641201 A22025-10-297356P23246Espacenet
JP 2025147176 A2025-10-0615607P23246Espacenet
JP 2025517969 A2025-06-127356P23246Espacenet
JP 2025028160 A2025-02-2815607P23246Espacenet
KR 1020250010750 A2025-01-2115607P23246Espacenet
JP 2024109657 A2024-08-1415446P23246Espacenet
US 11860162 B22024-01-021247P23246Espacenet
WO 2023157460 A2023-08-241P23246Espacenet
US 11446398 B22022-09-2083636P23246Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,450

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSFPQ papersNewest fiscal year
P30CA008748Cancer Center Support Grant262025
P30CA016672Cancer Center Support Grant112025
P50CA217694SPORE in Soft Tissue Sarcoma72025
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer72025
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene72025
ZIABC011043Molecular Therapeutics of Kidney Cancer: MET Gene and BHD Gene62025
ZIDBC011089Clinical Nursing and Data Management Core62025
P30CA016086Cancer Center Support Grant52025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center52025

1 to 10 of 1,450Source NIH's project files

See all 1,450 nih grants

Papers2,252

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RBP-Driven RNA sorting and local translation establish the molecular identities of individual sensory axons.Nat Commun202642811023PubTator, text miningPubMed
PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development.Elife202642770556PubTator, text miningPubMed
Engineering a protein homodimer from a heterodimer: A chimeric DBHS protein.Protein Sci202642765842PubTator, text miningPubMed
CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism.Signal Transduct Target Ther202642686681PubTator, text miningPubMed
CELF2 promotes 4R Tau splicing via nuclear clustering and drives cognitive dysfunction in tauopathy models.Nat Commun202642660921PubTator, text miningPubMed
RNA decay rate as a control point for long non-coding RNA function: a BRIC-based causal analysis of NEAT1.Gene202642628853PubTator, text miningPubMed
Splicing factor proline- and glutamine-rich (SFPQ) protein causes transcriptional repression of SNAIL to counteract TGF-β signaling.Biochim Biophys Acta Gene Regul Mech202642617997PubTator, text miningPubMed
Single-Cell Imaging of Site-Specific RNA-Protein Interactions.Angew Chem Int Ed Engl202642615282PubTator, text miningPubMed
CircHECTD1 Promotes Cholangiocarcinoma Progression Through Interaction With SFPQ to Induce Autophagy.Cancer Sci202642568173PubTator, text miningPubMed
Cross-species functional analysis of a de novo DCLK1 variant associated with a neurodevelopmental disorder.Res Sq202642539103PubTator, text miningPubMed

1 to 10 of 2,252

See all 2,252 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6421

GET https://conductscience.org/api/genes/v1/6421/patents?page=2