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Gene · 64223

MLST8: MTOR associated protein MLST8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MLST8: MTOR associated protein MLST8. Genes, record 64223. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64223

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Gene

Symbol
MLST8
HGNC
Name
MTOR associated protein MLST8
HGNC
NCBI Gene ID
64223
NCBI Gene
HGNC ID
HGNC:24825
HGNC
Ensembl
ENSG00000167965
NCBI Gene
Aliases
GBL, GbetaL, LST8, Lst8, POP3, Pop3, WAT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BVC4Target of rapamycin complex subunit LST832645Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454115Q9BVC4Espacenet
JP 2026004568 A2026-01-1454116Q9BVC4Espacenet
JP 2026004568 A2026-01-1454119Q9BVC4Espacenet
JP 2026004568 A2026-01-1454120Q9BVC4Espacenet
EP 4650780 A22025-11-1911457Q9BVC4Espacenet
JP 2025517970 A2025-06-1211457Q9BVC4Espacenet
US 11446398 B22022-09-2053068Q9BVC4Espacenet
US 11446398 B22022-09-2053072Q9BVC4Espacenet
US 11446398 B22022-09-2053080Q9BVC4Espacenet
US 11446398 B22022-09-2053082Q9BVC4Espacenet

1 to 10 of 41

See all 41 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
INDOXIMODCHEMBL571209mTORC1 activatorACTIVATOR

Source ChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05106296INDOXIMODPHASE1ClinicalTrials.gov
NCT04049669INDOXIMODPHASE2ClinicalTrials.gov
NCT03301636INDOXIMODPHASE22022-09-27ClinicalTrials.gov
NCT02835729INDOXIMODPHASE1ClinicalTrials.gov
NCT02502708INDOXIMODPHASE1ClinicalTrials.gov
NCT02460367INDOXIMODPHASE1ClinicalTrials.gov
NCT02077881INDOXIMODPHASE1/PHASE2ClinicalTrials.gov
NCT02073123INDOXIMODPHASE1/PHASE2ClinicalTrials.gov
NCT02052648INDOXIMODPHASE1/PHASE22024-03-27ClinicalTrials.gov
NCT01792050INDOXIMODPHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,779

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMLST8 papersNewest fiscal year
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes132025
P30CA016672Cancer Center Support Grant102025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center102025
P30CA006973Regional Oncology Research Center72025
P30CA008748Cancer Center Support Grant72025
P30CA014520UW Comprehensive Cancer Center Support52025
P30CA036727Buffett Cancer Center Support Grant52025
T32AI007247Cellular and Molecular Mechanisms of Immune Inflammatory Reactions52025
I01CX000916Signaling Pathways and Therapeutic Targeting of Leukemic Cells42025
P30CA054174Mays Cancer Center at UT Health SA42025

1 to 10 of 1,779Source NIH's project files

See all 1,779 nih grants

Papers2,397

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
γ-Butyrolactones and γ-butenolides as autoregulatory systems: key mediators of intraspecific, interspecific, and interkingdom communication in Streptomyces.Arch Microbiol202642701922PubTator, text miningPubMed
Phenethyl isothiocyanate mediates autophagy via the AMPK/mTOR signal pathway in human glioblastoma multiforme cells.Toxicol Appl Pharmacol202642503352PubTator, text miningPubMed
The role of mTORC2 in the in vitro neurotoxicity of Parkinsonian mimetics 6-OHDA and MPP.Neurotoxicology202642320558PubTator, text miningPubMed
Coordination-controlled photophysics and antiproliferative activity of coumarin-linked schiff bases and Zn(II) complexes.Photochem Photobiol Sci202642319660PubTator, text miningPubMed
Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination.Cell Death Discov202641872167PubTator, text miningPubMed
Time-Restricted Eating, Cardiometabolic Health in Obesity and The Optimal Length of the Eating Window.Curr Nutr Rep202641801605PubTator, text miningPubMed
mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review).Int J Mol Med202641789635PubTator, text miningPubMed
Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.Front Cell Neurosci202641788195PubTator, text miningPubMed
Transcranial direct current stimulation exerts neuroprotective effects in Parkinson's disease by restoring Mlst8-mediated autophagic homeostasis.J Transl Med202641484879PubTator, text miningPubMed
DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex.Adv Sci (Weinh)202641047465PubTator, text miningPubMed

1 to 10 of 2,397

See all 2,397 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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