Gene · 64223
MLST8: MTOR associated protein MLST8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MLST8: MTOR associated protein MLST8. Genes, record 64223. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64223
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9BVC4 | Target of rapamycin complex subunit LST8 | 326 | 45 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54115 | Q9BVC4 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54116 | Q9BVC4 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54119 | Q9BVC4 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54120 | Q9BVC4 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11457 | Q9BVC4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 11457 | Q9BVC4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 53068 | Q9BVC4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 53072 | Q9BVC4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 53080 | Q9BVC4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 53082 | Q9BVC4 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| INDOXIMOD | CHEMBL571209 | mTORC1 activator | ACTIVATOR |
Source ChEMBL
Trials11
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05106296 | INDOXIMOD | PHASE1 | ClinicalTrials.gov | |
| NCT04049669 | INDOXIMOD | PHASE2 | ClinicalTrials.gov | |
| NCT03301636 | INDOXIMOD | PHASE2 | 2022-09-27 | ClinicalTrials.gov |
| NCT02835729 | INDOXIMOD | PHASE1 | ClinicalTrials.gov | |
| NCT02502708 | INDOXIMOD | PHASE1 | ClinicalTrials.gov | |
| NCT02460367 | INDOXIMOD | PHASE1 | ClinicalTrials.gov | |
| NCT02077881 | INDOXIMOD | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02073123 | INDOXIMOD | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02052648 | INDOXIMOD | PHASE1/PHASE2 | 2024-03-27 | ClinicalTrials.gov |
| NCT01792050 | INDOXIMOD | PHASE2 | ClinicalTrials.gov |
1 to 10 of 11
See all 11 trialsNIH grants1,779
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MLST8 papers | Newest fiscal year |
|---|---|---|---|
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 10 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 5 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 5 | 2025 |
| T32AI007247 | Cellular and Molecular Mechanisms of Immune Inflammatory Reactions | 5 | 2025 |
| I01CX000916 | Signaling Pathways and Therapeutic Targeting of Leukemic Cells | 4 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 4 | 2025 |
1 to 10 of 1,779Source NIH's project files
See all 1,779 nih grantsPapers2,397
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| γ-Butyrolactones and γ-butenolides as autoregulatory systems: key mediators of intraspecific, interspecific, and interkingdom communication in Streptomyces. | Arch Microbiol | 2026 | 42701922 | PubTator, text mining | PubMed |
| Phenethyl isothiocyanate mediates autophagy via the AMPK/mTOR signal pathway in human glioblastoma multiforme cells. | Toxicol Appl Pharmacol | 2026 | 42503352 | PubTator, text mining | PubMed |
| The role of mTORC2 in the in vitro neurotoxicity of Parkinsonian mimetics 6-OHDA and MPP. | Neurotoxicology | 2026 | 42320558 | PubTator, text mining | PubMed |
| Coordination-controlled photophysics and antiproliferative activity of coumarin-linked schiff bases and Zn(II) complexes. | Photochem Photobiol Sci | 2026 | 42319660 | PubTator, text mining | PubMed |
| Deciphering the STAT3-PXN positive feedback loop in GBM, IDH-wildtype: transcriptional regulation and inhibition of YB-1 ubiquitination. | Cell Death Discov | 2026 | 41872167 | PubTator, text mining | PubMed |
| Time-Restricted Eating, Cardiometabolic Health in Obesity and The Optimal Length of the Eating Window. | Curr Nutr Rep | 2026 | 41801605 | PubTator, text mining | PubMed |
| mTOR signaling pathway in primary Sjögren's syndrome: Pathogenesis and potential therapeutic targets (Review). | Int J Mol Med | 2026 | 41789635 | PubTator, text mining | PubMed |
| Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies. | Front Cell Neurosci | 2026 | 41788195 | PubTator, text mining | PubMed |
| Transcranial direct current stimulation exerts neuroprotective effects in Parkinson's disease by restoring Mlst8-mediated autophagic homeostasis. | J Transl Med | 2026 | 41484879 | PubTator, text mining | PubMed |
| DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex. | Adv Sci (Weinh) | 2026 | 41047465 | PubTator, text mining | PubMed |
1 to 10 of 2,397
See all 2,397 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/64223
GET https://conductscience.org/api/genes/v1/64223/patents?page=2