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Gene · 6423

SFRP2: secreted frizzled related protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SFRP2: secreted frizzled related protein 2. Genes, record 6423. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6423

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Gene

Symbol
SFRP2
HGNC
Name
secreted frizzled related protein 2
HGNC
NCBI Gene ID
6423
NCBI Gene
HGNC ID
HGNC:10777
HGNC
Ensembl
ENSG00000145423
NCBI Gene
Aliases
FRP-2, SARP1, SDF-5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96HF1Secreted frizzled-related protein 22950Ensembl, GeneID, HGNC

Source UniProt

Patents84

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462815Q96HF1Espacenet
EP 4650780 A22025-11-192887Q96HF1Espacenet
EP 4641201 A22025-10-292453Q96HF1Espacenet
JP 2025147176 A2025-10-0612157Q96HF1Espacenet
JP 2025529142 A2025-09-047698Q96HF1Espacenet
US 12371689 B22025-07-297698Q96HF1Espacenet
JP 2025517969 A2025-06-122453Q96HF1Espacenet
JP 2025517970 A2025-06-122887Q96HF1Espacenet
JP 2025028160 A2025-02-2812157Q96HF1Espacenet
KR 1020250010750 A2025-01-2112157Q96HF1Espacenet

1 to 10 of 84

See all 84 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,570

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSFRP2 papersNewest fiscal year
P30CA006973Regional Oncology Research Center112025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center102025
P30CA010815Consolidated Basic Cancer Research Program102025
P30CA015704Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
R01AI022553Molecular Analysis of Host Immune Response in Leprosy62025
R01AR040312CD1-restricted T-cell Responses in Skin62025
K08AR078251Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway42025
K24AR076975Linking Disease Mechanisms and Outcomes in Rheumatic Diseases42025
P30CA068485Cancer Center Support Grant42025

1 to 10 of 1,570Source NIH's project files

See all 1,570 nih grants

Papers2,833

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Secreted frizzled-related protein 2 as a context-dependent extracellular signaling hub in development, tissue remodeling, and disease.Front Cell Dev Biol202642756375PubTator, text miningPubMed
SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11.J Cell Mol Med202642725854PubTator, text miningPubMed
Multi-omics profiling of circulating proteins and metabolites in persistent atrial fibrillation: VDAC1 identified as a candidate circulating protein.Int J Cardiol Heart Vasc202642724651PubTator, text miningPubMed
Immune niche composed of C1Q+ macrophages/SFRP2+ CAFs/CD8+ T cells drives immunotherapy response in HER2-positive gastric cancer.Nat Commun202642706281PubTator, text miningPubMed
Secreted Frizzled-Related Protein 2 (SFRP2) Induces Follistatin-Like 1 (FSTL1) to Regulate Dihydrotestosterone (DHT)-Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence.Aging Cell202642698274PubTator, text miningPubMed
Transcriptomic profiling of thyroid eye disease orbital fibroblasts identifies sorafenib as a novel therapeutic.Front Endocrinol (Lausanne)202642688036PubTator, text miningPubMed
Regulation of lambdoid suture morphogenesis by PDGFRα-dependent chondrocyte programs.Development202642581656PubTator, text miningPubMed
[Application of a plasma-based ctDNA multimodal model featuring GSTP1 and SFRP2 methylation for early-stage hepatocellular carcinoma diagnosis].Zhonghua Yu Fang Yi Xue Za Zhi202642503933PubTator, text miningPubMed
Integrated single-cell and spatial transcriptomic analyses reveal an aging-associated fibroblast subtype linked to tumor progression in human skin.Front Med (Lausanne)202642494450PubTator, text miningPubMed
SFRP2+ CAFs Expressing Myofibroblastic Phenotype Are Involved in Glutamine Metabolism and Malignant Behaviors of Laryngeal Squamous Cell Carcinoma by Collaborating With ELAVL1 to Stabilize GID8 mRNA.Mol Carcinog202642472387PubTator, text miningPubMed

1 to 10 of 2,833

See all 2,833 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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