Gene · 6423
SFRP2: secreted frizzled related protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SFRP2: secreted frizzled related protein 2. Genes, record 6423. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6423
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96HF1 | Secreted frizzled-related protein 2 | 295 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents84
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 62815 | Q96HF1 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2887 | Q96HF1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2453 | Q96HF1 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 12157 | Q96HF1 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7698 | Q96HF1 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7698 | Q96HF1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2453 | Q96HF1 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2887 | Q96HF1 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 12157 | Q96HF1 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 12157 | Q96HF1 | Espacenet |
1 to 10 of 84
See all 84 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,570
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SFRP2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006973 | Regional Oncology Research Center | 11 | 2025 |
| P30AR075043 | University of Michigan Skin Biology and Diseases Resource-based Center | 10 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 10 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| R01AI022553 | Molecular Analysis of Host Immune Response in Leprosy | 6 | 2025 |
| R01AR040312 | CD1-restricted T-cell Responses in Skin | 6 | 2025 |
| K08AR078251 | Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway | 4 | 2025 |
| K24AR076975 | Linking Disease Mechanisms and Outcomes in Rheumatic Diseases | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,570Source NIH's project files
See all 1,570 nih grantsPapers2,833
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Secreted frizzled-related protein 2 as a context-dependent extracellular signaling hub in development, tissue remodeling, and disease. | Front Cell Dev Biol | 2026 | 42756375 | PubTator, text mining | PubMed |
| SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11. | J Cell Mol Med | 2026 | 42725854 | PubTator, text mining | PubMed |
| Multi-omics profiling of circulating proteins and metabolites in persistent atrial fibrillation: VDAC1 identified as a candidate circulating protein. | Int J Cardiol Heart Vasc | 2026 | 42724651 | PubTator, text mining | PubMed |
| Immune niche composed of C1Q+ macrophages/SFRP2+ CAFs/CD8+ T cells drives immunotherapy response in HER2-positive gastric cancer. | Nat Commun | 2026 | 42706281 | PubTator, text mining | PubMed |
| Secreted Frizzled-Related Protein 2 (SFRP2) Induces Follistatin-Like 1 (FSTL1) to Regulate Dihydrotestosterone (DHT)-Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence. | Aging Cell | 2026 | 42698274 | PubTator, text mining | PubMed |
| Transcriptomic profiling of thyroid eye disease orbital fibroblasts identifies sorafenib as a novel therapeutic. | Front Endocrinol (Lausanne) | 2026 | 42688036 | PubTator, text mining | PubMed |
| Regulation of lambdoid suture morphogenesis by PDGFRα-dependent chondrocyte programs. | Development | 2026 | 42581656 | PubTator, text mining | PubMed |
| [Application of a plasma-based ctDNA multimodal model featuring GSTP1 and SFRP2 methylation for early-stage hepatocellular carcinoma diagnosis]. | Zhonghua Yu Fang Yi Xue Za Zhi | 2026 | 42503933 | PubTator, text mining | PubMed |
| Integrated single-cell and spatial transcriptomic analyses reveal an aging-associated fibroblast subtype linked to tumor progression in human skin. | Front Med (Lausanne) | 2026 | 42494450 | PubTator, text mining | PubMed |
| SFRP2+ CAFs Expressing Myofibroblastic Phenotype Are Involved in Glutamine Metabolism and Malignant Behaviors of Laryngeal Squamous Cell Carcinoma by Collaborating With ELAVL1 to Stabilize GID8 mRNA. | Mol Carcinog | 2026 | 42472387 | PubTator, text mining | PubMed |
1 to 10 of 2,833
See all 2,833 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6423
GET https://conductscience.org/api/genes/v1/6423/patents?page=2