ConductScience.org, home

Gene · 6424

SFRP4: secreted frizzled related protein 4

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SFRP4: secreted frizzled related protein 4. Genes, record 6424. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6424

On this page

Gene

Symbol
SFRP4
HGNC
Name
secreted frizzled related protein 4
HGNC
NCBI Gene ID
6424
NCBI Gene
HGNC ID
HGNC:10778
HGNC
Ensembl
ENSG00000106483
NCBI Gene
Aliases
FRP-4, FRPHE, FRZB-2, PYL, frpHE, sFRP-4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q6FHJ7Secreted frizzled-related protein 43460Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1913659Q6FHJ7Espacenet
JP 2025147176 A2025-10-0612158Q6FHJ7Espacenet
JP 2025529142 A2025-09-047699Q6FHJ7Espacenet
US 12371689 B22025-07-297699Q6FHJ7Espacenet
JP 2025517970 A2025-06-1213659Q6FHJ7Espacenet
JP 2025028160 A2025-02-2812158Q6FHJ7Espacenet
KR 1020250010750 A2025-01-2112158Q6FHJ7Espacenet
JP 2024123008 A2024-09-108315Q6FHJ7Espacenet
JP 2024109657 A2024-08-1412165Q6FHJ7Espacenet
US 11446398 B22022-09-2076985Q6FHJ7Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,138

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSFRP4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA015704Cancer Center Support Grant62025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center52025
P30CA008748Cancer Center Support Grant42025
P30CA062203Cancer Center Support Grant42025
R01AI022553Molecular Analysis of Host Immune Response in Leprosy42025
R01AR040312CD1-restricted T-cell Responses in Skin42025
R35GM119840Chemical biology approaches to probe signaling by protein lipidation42025
K08AR078251Mechanisms of sex discrepancy in autoimmune disease: Regulation of the female-biased VGLL3 immune pathway32025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases32025

1 to 10 of 1,138Source NIH's project files

See all 1,138 nih grants

Papers2,245

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Abscisic Acid-Mediated Drought Tolerance in Populus: Physiological, Molecular, and Biotechnological Perspectives.Curr Issues Mol Biol202642793303PubTator, text miningPubMed
The Role of Circulating Secreted Frizzled-Related Protein 4 (SFRP4) in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Diabetes Res Clin Pract202642759570PubTator, text miningPubMed
Physiological response to drought and genome wide characterization of PYL-PP2C genes in Eucalyptus spp.Plant Physiol Biochem202642623704PubTator, text miningPubMed
Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in nonhuman primates.Cell Discov202642552301PubTator, text miningPubMed
Pyle disease - Functional validation of disease-causing missense variants in SFRP4/sFRP4.Bone202642532397PubTator, text miningPubMed
Ultrasound-Assisted Cerium-Doped Zeolite Nanocomplex Attenuates Adenomyosis via Wnt/beta-Catenin Pathway Inhibition and IGFBP5 Downregulation in SFRP4+ NKT Cells.Physiol Res202642466702PubTator, text miningPubMed
The Janus Face of sFRP4 in Cancer: From Mechanistic Complexity to Therapeutic Potential.Int J Mol Sci202642449967PubTator, text miningPubMed
Uncovering alterations in cancer epigenetics via trans-dimensional Markov chain Monte Carlo and hidden Markov models.J R Stat Soc Ser C Appl Stat202642389235PubTator, text miningPubMed
Case Report: Cortical bone loss, impaired mineralization, and reduced adiposity contributing to chronic bone pain in SFRP4-related skeletal disease with an ALPL variant.Front Endocrinol (Lausanne)202642381879PubTator, text miningPubMed
sFRP-4 regulated by n6‑methyladenosine writer ZC3H13 attenuates sunitinib resistance of renal cell carcinoma via inactivating Wnt/β-catenin pathway.Sci Rep202642374135PubTator, text miningPubMed

1 to 10 of 2,245

See all 2,245 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6424

GET https://conductscience.org/api/genes/v1/6424/patents?page=2