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Gene · 6431

SRSF6: serine and arginine rich splicing factor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SRSF6: serine and arginine rich splicing factor 6. Genes, record 6431. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6431

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Gene

Symbol
SRSF6
HGNC
Name
serine and arginine rich splicing factor 6
HGNC
NCBI Gene ID
6431
NCBI Gene
HGNC ID
HGNC:10788
HGNC
Ensembl
ENSG00000124193
NCBI Gene
Aliases
B52, HEL-S-91, SFRS6, SRP55
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13247Serine/arginine-rich splicing factor 63443Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463102Q13247Espacenet
EP 4650780 A22025-11-191110Q13247Espacenet
EP 4641201 A22025-10-29783Q13247Espacenet
JP 2025517969 A2025-06-12783Q13247Espacenet
JP 2025517970 A2025-06-121110Q13247Espacenet
US 11446398 B22022-09-2077783Q13247Espacenet
JP 2022524081 A2022-04-27180754Q13247Espacenet
US 11078247 B22021-08-0310997Q13247Espacenet
EP 3813826 A12021-05-0525Q13247Espacenet
WO 2020043864 A12020-03-052474Q13247Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,006

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSRSF6 papersNewest fiscal year
P01CA013106Targeting Transcription and Splicing in Cancer122025
P30CA045508CSHL Cancer Center Support Grant102025
R01GM042699Biochemistry of Pre-mRNA Splicing92025
P30CA016086Cancer Center Support Grant52025
ZIASC010357Gene Expression and Post-Transcriptional Regulation of DNA Tumor Viruses52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA034196Cancer Center Support (CORE) Grant42025
P30CA016042Cancer Center Support Grant32025
P50CA116201Mayo Clinic Breast Cancer SPORE32025

1 to 10 of 1,006Source NIH's project files

See all 1,006 nih grants

Papers1,479

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genome-scale CRISPR screening uncovers SRSF6 as a target to sensitize hepatocellular carcinoma to radiotherapy.JHEP Rep202642586203PubTator, text miningPubMed
Serine Starvation Modulates mRNA Splicing through Translational Inhibition of SRSF Proteins.Cancer Res202642484423PubTator, text miningPubMed
Predicting human mRNA isoform levels from site-specific splicing kinetics in silico.bioRxiv202642367929PubTator, text miningPubMed
Targeting SRSF6 to Enhance Cisplatin Sensitivity by Modulating Redox Balance via NFE2L1 exon 4 Splicing in ESCC.Int J Biol Sci202642328451PubTator, text miningPubMed
1H, 13C, 15N backbone chemical shift assignments and relaxation analysis of the single and tandem RRMs of the human serine-arginine rich splicing factor 6 (SRSF6).J Magn Reson202642102650PubTator, text miningPubMed
Multimodal AI fuses proteomic and EHR data for rational prioritization of protein biomarkers in diabetic retinopathy.medRxiv202641918763PubTator, text miningPubMed
[Expression, Prognostic and Functional Analysis of SRSF Family Proteins in Non-small Cell Lung Cancer].Zhongguo Fei Ai Za Zhi202641916911PubTator, text miningPubMed
The tRNA-Derived Fragment tRF-E Promotes Ferroptosis in Hepatocellular Carcinoma to Suppress Tumor Progression.Cancer Res202641886622PubTator, text miningPubMed
The human branchpoint-interacting stem-loop sequence and structure regulates U2 snRNA expression, branchpoint recognition, and the transcriptome.Nucleic Acids Res202641885209PubTator, text miningPubMed
Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia.Cell Death Discov202641876469PubTator, text miningPubMed

1 to 10 of 1,479

See all 1,479 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6431

GET https://conductscience.org/api/genes/v1/6431/patents