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Gene · 64324

NSD1: nuclear receptor binding SET domain protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NSD1: nuclear receptor binding SET domain protein 1. Genes, record 64324. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64324

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Gene

Symbol
NSD1
HGNC
Name
nuclear receptor binding SET domain protein 1
HGNC
NCBI Gene ID
64324
NCBI Gene
HGNC ID
HGNC:14234
HGNC
Ensembl
ENSG00000165671
NCBI Gene
Aliases
ARA267, FLJ22263, KMT3B, SOTOS, SOTOS1, STO
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96L73Histone-lysine N-methyltransferase, H3 lysine-36 specific2,6964Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456085Q96L73Espacenet
EP 4641201 A22025-10-2914169Q96L73Espacenet
JP 2025517969 A2025-06-1214169Q96L73Espacenet
JP 2023549761 A2023-11-29236Q96L73Espacenet
JP 2022141755 A2022-09-29232Q96L73Espacenet
US 11446398 B22022-09-2058291Q96L73Espacenet
JP 2022524081 A2022-04-27161262Q96L73Espacenet
US 11136562 B22021-10-05293Q96L73Espacenet
JP 2019054813 A2019-04-11236520Q96L73Espacenet
JP 2019507586 A2019-03-225Q96L73Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,401

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNSD1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant372025
P30CA016672Cancer Center Support Grant212025
P30CA021765Cancer Center Support Grant (CCSG)202025
U10CA180899Children's Oncology Group Statistics and Data Center122025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement112025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92025
P30CA016086Cancer Center Support Grant82025
P30CA091842Cancer Center Support Grant82025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias72025
R01AI118891Viral modulation of epitranscriptomic mechanisms62025

1 to 10 of 1,401Source NIH's project files

See all 1,401 nih grants

Papers2,293

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Thoracic Aortic Disease in Genetic Syndromes Beyond Established Aortopathy Genes.medRxiv202642818859PubTator, text miningPubMed
NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting.Int J Mol Sci202642794546PubTator, text miningPubMed
Unmasked Behavioral Disturbance Following Traumatic Brain Injury in an Adult With Previously Undiagnosed Sotos Syndrome.Cureus202642621581PubTator, text miningPubMed
Sotos and Malan Syndromes in Childhood: Molecular and Clinical Findings From a Nationwide Cohort of 48 Patients.Clin Genet202642618064PubTator, text miningPubMed
Genetic Etiology and Neurodevelopmental Outcomes in Children With Craniosynostosis: A 15-Year Single-Center Retrospective Study.J Craniofac Surg202642607197PubTator, text miningPubMed
Gonocytes in Transition: Establishing the Male Germline Identity.Adv Exp Med Biol202642455434PubTator, text miningPubMed
Overcoming Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC): The Role of Histone Methyltransferase and Demethylase Inhibitors.Cancers (Basel)202642449712PubTator, text miningPubMed
Oncogenic PIK3CA mutation enhances tumor immunogenicity through the IRF1-NLRC5-MHC-I axis in urothelial carcinoma.J Immunother Cancer202642413983PubTator, text miningPubMed
Management of Acute Myeloid Leukemia in a Dialysis-Dependent Patient: A Case Report, Literature Review, and Therapeutic Considerations.Cureus202642292729PubTator, text miningPubMed
Clinical characterization and developmental follow-up of a child with Sotos syndrome carrying a novel NSD1 variant.BMC Pediatr202642286513PubTator, text miningPubMed

1 to 10 of 2,293

See all 2,293 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/64324

GET https://conductscience.org/api/genes/v1/64324/patents?page=2