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Gene · 64344

HIF3A: hypoxia inducible factor 3 subunit alpha

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HIF3A: hypoxia inducible factor 3 subunit alpha. Genes, record 64344. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64344

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Gene

Symbol
HIF3A
HGNC
Name
hypoxia inducible factor 3 subunit alpha
HGNC
NCBI Gene ID
64344
NCBI Gene
HGNC ID
HGNC:15825
HGNC
Ensembl
ENSG00000124440
NCBI Gene
Aliases
HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y2N7Hypoxia-inducible factor 3-alpha6691Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449589Q9Y2N7Espacenet
JP 2025147176 A2025-10-0615085Q9Y2N7Espacenet
JP 2025032204 A2025-03-1129560Q9Y2N7Espacenet
JP 2025028160 A2025-02-2815085Q9Y2N7Espacenet
KR 1020250010750 A2025-01-2115085Q9Y2N7Espacenet
EP 4461818 A22024-11-1329560Q9Y2N7Espacenet
JP 2024109657 A2024-08-1414924Q9Y2N7Espacenet
US 11708396 B22023-07-252402Q9Y2N7Espacenet
JP 2023058610 A2023-04-2529560Q9Y2N7Espacenet
US 11446398 B22022-09-2039386Q9Y2N7Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,158

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHIF3A papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA086862Cancer Center Support Grant52025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)52025
P01CA108671Myeloproliferative Neoplasms-Research Consortium42025
P30CA016086Cancer Center Support Grant42025
P30ES005605Environmental Health Sciences Research Center42025
ZIANS003053Neuro-oncology of Familial Neoplasia Syndromes42025
I01BX002348Cellular and Molecular Mechanisms of Renal Anemia32025
P30CA006973Regional Oncology Research Center32025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)32025

1 to 10 of 1,158Source NIH's project files

See all 1,158 nih grants

Papers1,940

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Time-Resolved Network Entropy Analysis Identifies a CTNND1-VAV3 Subnetwork in Gefitinib-Resistant NSCLC.Int J Mol Sci202642794834PubTator, text miningPubMed
Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF-3α-BNIP3 Axis.Aging Cell202642775695PubTator, text miningPubMed
HIF-2α Depletion and HIF-1α Overexpression in Vulnerable Brain Regions Distinguish Alzheimer's Disease with Cerebral Amyloid Angiopathy.Int J Mol Sci202642737681PubTator, text miningPubMed
HIFs: The central drivers of tumors and their role as molecular switches in targeted therapy?Acta Pharm Sin B202642592210PubTator, text miningPubMed
Post-Treatment Persistent Erythrocytosis in Patients with Hodgkin Lymphoma: Molecular Mechanisms Underlying the Pathogenesis of Erythrocytosis.Cancers (Basel)202642588719PubTator, text miningPubMed
Reduced Circulating HIF-1α, HIF-2α, HIF-3α, and VHL Levels in Patients With Pulmonary Arterial Hypertension.Pulm Circ202642254878PubTator, text miningPubMed
Regulatory mechanisms of hypoxia-inducible factors on ferroptosis in ischemic stroke.PeerJ202642254662PubTator, text miningPubMed
Hypoxia-Induced MicroRNAs Confer Survival Advantage in Bladder Cancer by Fine-Tuning Oncogenic Pathways.Oncology202641945479PubTator, text miningPubMed
An Activity-Dependent NEPAS-PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment.Adv Sci (Weinh)202641944308PubTator, text miningPubMed
Research progress of mesenchymal stem cells/stromal cells and their derivatives against cell senescence in the treatment of osteoarthritis.Ann Med202641919394PubTator, text miningPubMed

1 to 10 of 1,940

See all 1,940 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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