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Gene · 64399

HHIP: hedgehog interacting protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HHIP: hedgehog interacting protein. Genes, record 64399. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64399

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Gene

Symbol
HHIP
HGNC
Name
hedgehog interacting protein
HGNC
NCBI Gene ID
64399
NCBI Gene
HGNC ID
HGNC:14866
HGNC
Ensembl
ENSG00000164161
NCBI Gene
Aliases
FLJ20992, HIP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96QV1Hedgehog-interacting protein70011Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448856Q96QV1Espacenet
EP 4650780 A22025-11-193743Q96QV1Espacenet
EP 4641201 A22025-10-293320Q96QV1Espacenet
JP 2025147176 A2025-10-066465Q96QV1Espacenet
JP 2025529142 A2025-09-041946Q96QV1Espacenet
JP 2025529142 A2025-09-046587Q96QV1Espacenet
US 12371689 B22025-07-291946Q96QV1Espacenet
US 12371689 B22025-07-296587Q96QV1Espacenet
JP 2025517969 A2025-06-123320Q96QV1Espacenet
JP 2025517970 A2025-06-123743Q96QV1Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,180

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHHIP papersNewest fiscal year
P01HL114501Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers112025
P30CA016672Cancer Center Support Grant112025
P30DK063491Diabetes Research Center (DRC)112025
P30CA008748Cancer Center Support Grant92025
R01HL077612Precision phenotyping of emphysema in the elderly: the MESA Lung Study82025
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum72025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES72025
ZIAES043012Genetics and Environment in Adult Respiratory, Allergic and Cardiac disease72025
R01DK070855Microbial Regulation of Retinol Transport and its Role in Intestinal Immunity62025

1 to 10 of 2,180Source NIH's project files

See all 2,180 nih grants

Papers2,545

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Midazolam Reduces Metabolic Viability and Induces Apoptosis in MIA PaCa-2 Pancreatic Cancer Cells with Selective Transcriptional Modulation of Wnt and Hedgehog Components: A Preliminary In Vitro Study.
Pharmaceuticals (Basel)202642797517PubTator, text miningPubMed
A multi-level machine learning pipeline for prediction and prioritization of hybrid insulin peptides in type 1 diabetes.Front Immunol202642630244PubTator, text miningPubMed
Hippocampal subfield radiomics reveals the link between inflammatory status and mild cognitive impairment in patients with non-dialysis chronic kidney disease.Front Neurosci202642609489PubTator, text miningPubMed
Investigation and validation of prognostic features associated with transient receptor potential channel genes in gastric cancer.PeerJ202642602890PubTator, text miningPubMed
Foot Turnout and Knee Alignment Affect the Transverse Plane Hip Moment in Barbell Squats.J Strength Cond Res202642479711PubTator, text miningPubMed
B-type host stars revealed by exoplanets around massive secondary-clump giant stars.Nat Commun202642477353PubTator, text miningPubMed
Genetic susceptibility to COPD: Systematic review, bibliometric analysis and meta-analysis of SERPINA1, HHIP, IREB2, SFTPD, and FAM13A.Respir Investig202642269416PubTator, text miningPubMed
Corrigendum to "Differential promoter usages of PTCH1 and down regulation of HHIP are associated with HNSCC progression" [Pathol. Res. Pract. 232 (2022) 153827].Pathol Res Pract202642000219PubTator, text miningPubMed
RNA-Sequencing Reveals Two Subgroups of Eccrine Porocarcinomas and Poromas.J Cell Mol Med202641981783PubTator, text miningPubMed
The test-retest reliability and agreement between a fixed frame and belt-stabilised handheld dynamometer for isometric hip flexion and extension peak force measurement in recreational cyclists.PLoS One202641931523PubTator, text miningPubMed

1 to 10 of 2,545

See all 2,545 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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