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Gene · 6470

SHMT1: serine hydroxymethyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SHMT1: serine hydroxymethyltransferase 1. Genes, record 6470. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6470

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Gene

Symbol
SHMT1
HGNC
Name
serine hydroxymethyltransferase 1
HGNC
NCBI Gene ID
6470
NCBI Gene
HGNC ID
HGNC:10850
HGNC
Ensembl
ENSG00000176974
NCBI Gene
Aliases
CSHMT, MGC15229, MGC24556, SHMT, cSHMT, hcSHMT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P34896Serine hydroxymethyltransferase, cytosolic4838Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463018P34896Espacenet
EP 4650780 A22025-11-195220P34896Espacenet
JP 2025517970 A2025-06-125220P34896Espacenet
US 11446398 B22022-09-2077594P34896Espacenet
JP 2022524081 A2022-04-27180565P34896Espacenet
WO 2020043864 A12020-03-051016P34896Espacenet
JP 2019054813 A2019-04-11243453P34896Espacenet
WO 2017156362 A12017-09-1411P34896Espacenet
JP 2017121241 A2017-07-13243453P34896Espacenet
EP 3008180 A22016-04-2025P34896Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,251

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSHMT1 papersNewest fiscal year
R01CA163591Tumor cell metabolism in action122025
P30CA072720Cancer Center Support Grant82025
P42ES004705Toxic substances in the environment82025
T32DK007158NUTRITION TRAINING82025
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
P30ES009089Center for Environmental Health in Northern Manhattan62025
T32CA009531Training Program in the Biology of Cancer62025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA030199Cancer Center Support Grant (CCSG)52025

1 to 10 of 1,251Source NIH's project files

See all 1,251 nih grants

Papers1,819

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Priming Impacts of Early Hypoxia Exposure in Abalone Parents Are Transmitted to Offspring.Mol Ecol202642501344PubTator, text miningPubMed
One-carbon metabolism upregulated in lupus promotes the differentiation and effector functions of human B and T cells.Rheumatology (Oxford)202642490203PubTator, text miningPubMed
Ischemic Stroke Increases Protein Expression of the Folate Receptor and One-carbon Enzymes in Brain Tissue From Male and Female Patients.Transl Stroke Res202642489762PubTator, text miningPubMed
Integrative single-cell and multi-omics analysis of ZBTB21-mediated serine metabolism in colorectal cancer: from metabolic reprogramming to immune microenvironment modulation.Cancer Immunol Immunother202642400616PubTator, text miningPubMed
Comparative binding and activity analysis of known serine hydroxymethyltransferase inhibitors in biochemical assays.RSC Adv202642395815PubTator, text miningPubMed
Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis.J Cardiovasc Transl Res202642380371PubTator, text miningPubMed
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma.Front Cell Dev Biol202642326014PubTator, text miningPubMed
β-Hydroxybutyrate elicits divergent metabolic responses between MCF-7 and T47D ER+ breast cancer cells under glucose restriction.bioRxiv202642239348PubTator, text miningPubMed
Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.J Transl Med202642015255PubTator, text miningPubMed
Plasma serine and glycine in relation to clinical outcomes following neoadjuvant radiotherapy for rectal cancer.Clin Transl Radiat Oncol202642005714PubTator, text miningPubMed

1 to 10 of 1,819

See all 1,819 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6470

GET https://conductscience.org/api/genes/v1/6470/patents