Gene · 6470
SHMT1: serine hydroxymethyltransferase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SHMT1: serine hydroxymethyltransferase 1. Genes, record 6470. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6470
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P34896 | Serine hydroxymethyltransferase, cytosolic | 483 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63018 | P34896 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5220 | P34896 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5220 | P34896 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 77594 | P34896 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 180565 | P34896 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1016 | P34896 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 243453 | P34896 | Espacenet |
| WO 2017156362 A1 | 2017-09-14 | 11 | P34896 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 243453 | P34896 | Espacenet |
| EP 3008180 A2 | 2016-04-20 | 25 | P34896 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,251
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SHMT1 papers | Newest fiscal year |
|---|---|---|---|
| R01CA163591 | Tumor cell metabolism in action | 12 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 8 | 2025 |
| P42ES004705 | Toxic substances in the environment | 8 | 2025 |
| T32DK007158 | NUTRITION TRAINING | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 6 | 2025 |
| T32CA009531 | Training Program in the Biology of Cancer | 6 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 5 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
1 to 10 of 1,251Source NIH's project files
See all 1,251 nih grantsPapers1,819
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The Priming Impacts of Early Hypoxia Exposure in Abalone Parents Are Transmitted to Offspring. | Mol Ecol | 2026 | 42501344 | PubTator, text mining | PubMed |
| One-carbon metabolism upregulated in lupus promotes the differentiation and effector functions of human B and T cells. | Rheumatology (Oxford) | 2026 | 42490203 | PubTator, text mining | PubMed |
| Ischemic Stroke Increases Protein Expression of the Folate Receptor and One-carbon Enzymes in Brain Tissue From Male and Female Patients. | Transl Stroke Res | 2026 | 42489762 | PubTator, text mining | PubMed |
| Integrative single-cell and multi-omics analysis of ZBTB21-mediated serine metabolism in colorectal cancer: from metabolic reprogramming to immune microenvironment modulation. | Cancer Immunol Immunother | 2026 | 42400616 | PubTator, text mining | PubMed |
| Comparative binding and activity analysis of known serine hydroxymethyltransferase inhibitors in biochemical assays. | RSC Adv | 2026 | 42395815 | PubTator, text mining | PubMed |
| Metabolic Heterogeneity Across Heart Failure Subtypes Defined by Integrative Multi-Omics Analysis. | J Cardiovasc Transl Res | 2026 | 42380371 | PubTator, text mining | PubMed |
| Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma. | Front Cell Dev Biol | 2026 | 42326014 | PubTator, text mining | PubMed |
| β-Hydroxybutyrate elicits divergent metabolic responses between MCF-7 and T47D ER+ breast cancer cells under glucose restriction. | bioRxiv | 2026 | 42239348 | PubTator, text mining | PubMed |
| Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting. | J Transl Med | 2026 | 42015255 | PubTator, text mining | PubMed |
| Plasma serine and glycine in relation to clinical outcomes following neoadjuvant radiotherapy for rectal cancer. | Clin Transl Radiat Oncol | 2026 | 42005714 | PubTator, text mining | PubMed |
1 to 10 of 1,819
See all 1,819 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6470
GET https://conductscience.org/api/genes/v1/6470/patents