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Gene · 6472

SHMT2: serine hydroxymethyltransferase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SHMT2: serine hydroxymethyltransferase 2. Genes, record 6472. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6472

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Gene

Symbol
SHMT2
HGNC
Name
serine hydroxymethyltransferase 2
HGNC
NCBI Gene ID
6472
NCBI Gene
HGNC ID
HGNC:10852
HGNC
Ensembl
ENSG00000182199
NCBI Gene
Aliases
GLYA, HEL-S-51e, NEDCASB, SHMT, mSHMT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P34897Serine hydroxymethyltransferase, mitochondrial50427Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463026P34897Espacenet
EP 4650780 A22025-11-196038P34897Espacenet
EP 4641201 A22025-10-295775P34897Espacenet
EP 4641202 A22025-10-295054P34897Espacenet
JP 2025517969 A2025-06-125775P34897Espacenet
JP 2025517970 A2025-06-126038P34897Espacenet
KR 1020250017231 A2025-02-045054P34897Espacenet
US 11446398 B22022-09-2077600P34897Espacenet
JP 2022524081 A2022-04-27180571P34897Espacenet
US 10894989 B22021-01-1924P34897Espacenet

1 to 10 of 61

See all 61 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,464

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSHMT2 papersNewest fiscal year
R01CA163591Tumor cell metabolism in action132025
P30CA008748Cancer Center Support Grant122025
T32CA009531Training Program in the Biology of Cancer92025
T32DK007158NUTRITION TRAINING92025
P30CA072720Cancer Center Support Grant82025
P30CA022453CANCER CENTER SUPPORT GRANT72025
R01CA250469Therapeutic Targeting Mitochondrial C1 Metabolism72025
P30CA010815Consolidated Basic Cancer Research Program62025
P30CA014051Cancer Center Support (Core) Grant62025
P30CA016672Cancer Center Support Grant62025

1 to 10 of 1,464Source NIH's project files

See all 1,464 nih grants

Papers2,556

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Stephania cepharantha Hayata (Baiyaozi) attenuates cirrhosis-associated intestinal barrier injury by restoring mitochondrial function and suppressing PI3K/AKT signaling.J Ethnopharmacol202742586397PubTator, text miningPubMed
Direct Asymmetric Synthesis of Chiral β-Hydroxy-α-Amino Amides via PLP-Inspired Biomimetic Aldol Reaction.Angew Chem Int Ed Engl202642806590PubTator, text miningPubMed
PPIB and its role in prostate cancer: associations with transcriptomic and splicing alterations.Front Oncol202642774112PubTator, text miningPubMed
Metabolic licensing of quiescent glioblastoma activation and immune evasion via astrocyte-mitochondria shuttle.Nat Commun202642768016PubTator, text miningPubMed
SHMT2: a Metabolic and Immune Biomarker of Aggressive Lung Adenocarcinoma.J Vis Exp202642667191PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Research on serine hydroxymethyltransferase 2 mechanisms in malignant tumor development and progression.PeerJ202642633427PubTator, text miningPubMed
Polyamines buffer labile iron to suppress ferroptosis.Cell202642600612PubTator, text miningPubMed
Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation.FASEB J202642543917PubTator, text miningPubMed
Epitranscriptomic Regulation of ALDOA by SHMT2-Mediated m6A Modification Drives Gastric Cancer Malignancy.Mol Carcinog202642541491PubTator, text miningPubMed

1 to 10 of 2,556

See all 2,556 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6472

GET https://conductscience.org/api/genes/v1/6472/patents?page=2