Gene · 6472
SHMT2: serine hydroxymethyltransferase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SHMT2: serine hydroxymethyltransferase 2. Genes, record 6472. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6472
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P34897 | Serine hydroxymethyltransferase, mitochondrial | 504 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents61
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63026 | P34897 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6038 | P34897 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5775 | P34897 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5054 | P34897 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5775 | P34897 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6038 | P34897 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5054 | P34897 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 77600 | P34897 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 180571 | P34897 | Espacenet |
| US 10894989 B2 | 2021-01-19 | 24 | P34897 | Espacenet |
1 to 10 of 61
See all 61 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,464
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SHMT2 papers | Newest fiscal year |
|---|---|---|---|
| R01CA163591 | Tumor cell metabolism in action | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| T32CA009531 | Training Program in the Biology of Cancer | 9 | 2025 |
| T32DK007158 | NUTRITION TRAINING | 9 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 8 | 2025 |
| P30CA022453 | CANCER CENTER SUPPORT GRANT | 7 | 2025 |
| R01CA250469 | Therapeutic Targeting Mitochondrial C1 Metabolism | 7 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 6 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 1,464Source NIH's project files
See all 1,464 nih grantsPapers2,556
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Stephania cepharantha Hayata (Baiyaozi) attenuates cirrhosis-associated intestinal barrier injury by restoring mitochondrial function and suppressing PI3K/AKT signaling. | J Ethnopharmacol | 2027 | 42586397 | PubTator, text mining | PubMed |
| Direct Asymmetric Synthesis of Chiral β-Hydroxy-α-Amino Amides via PLP-Inspired Biomimetic Aldol Reaction. | Angew Chem Int Ed Engl | 2026 | 42806590 | PubTator, text mining | PubMed |
| PPIB and its role in prostate cancer: associations with transcriptomic and splicing alterations. | Front Oncol | 2026 | 42774112 | PubTator, text mining | PubMed |
| Metabolic licensing of quiescent glioblastoma activation and immune evasion via astrocyte-mitochondria shuttle. | Nat Commun | 2026 | 42768016 | PubTator, text mining | PubMed |
| SHMT2: a Metabolic and Immune Biomarker of Aggressive Lung Adenocarcinoma. | J Vis Exp | 2026 | 42667191 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Research on serine hydroxymethyltransferase 2 mechanisms in malignant tumor development and progression. | PeerJ | 2026 | 42633427 | PubTator, text mining | PubMed |
| Polyamines buffer labile iron to suppress ferroptosis. | Cell | 2026 | 42600612 | PubTator, text mining | PubMed |
| Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation. | FASEB J | 2026 | 42543917 | PubTator, text mining | PubMed |
| Epitranscriptomic Regulation of ALDOA by SHMT2-Mediated m6A Modification Drives Gastric Cancer Malignancy. | Mol Carcinog | 2026 | 42541491 | PubTator, text mining | PubMed |
1 to 10 of 2,556
See all 2,556 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6472
GET https://conductscience.org/api/genes/v1/6472/patents?page=2