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Gene · 6473

SHOX: SHOX homeobox

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SHOX: SHOX homeobox. Genes, record 6473. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6473

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Gene

Symbol
SHOX
HGNC
Name
SHOX homeobox
HGNC
NCBI Gene ID
6473
NCBI Gene
HGNC ID
HGNC:10853
HGNC
Ensembl
ENSG00000185960, ENSG00000292354
NCBI Gene
Aliases
GCFX, PHOG, SHOX1, SHOXY, SS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15266Short stature homeobox protein2920Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463453O15266Espacenet
JP 2026004568 A2026-01-1463454O15266Espacenet
EP 4641201 A22025-10-2910805O15266Espacenet
JP 2025147176 A2025-10-0615608O15266Espacenet
JP 2025517969 A2025-06-1210805O15266Espacenet
JP 2025028160 A2025-02-2815608O15266Espacenet
KR 1020250010750 A2025-01-2115608O15266Espacenet
JP 2024109657 A2024-08-1415447O15266Espacenet
US 11446398 B22022-09-2078817O15266Espacenet
US 11446398 B22022-09-2078818O15266Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants391

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSHOX papersNewest fiscal year
ZIAHD000640Regulation Of Childhood Growth102025
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum32025
P40OD019794Ambystoma Genetic Stock Center22025
R01MH074090Gene Dosage Imbalance in Neurodevelopmental Disorders22025
T32GM008638Medical Genetics Research Training Grant22025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).22025
D43TW009114Psychiatric research infrastructure for intervention and implementation in India – TEAMS12025
IK6BX004854BLRD Research Career Scientist Award Application12025
K12GM093857Virginia Commonwealth University IRACDA12025
K12HD052896Child Health Research Career Development Award (CHRCDA) Program (K12)12025

1 to 10 of 391Source NIH's project files

See all 391 nih grants

Papers1,180

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Idiopathic short stature in the genomic era: a focused narrative review of genotype-phenotype correlation, selective neuroimaging, IGF-1 biology, and growth hormone responsiveness.Clin Pediatr Endocrinol202642824949PubTator, text miningPubMed
Brachydactyly Type A1 Caused by an IHH Variant in a Patient with Disproportionate Short Stature: A Case Report.Reports (MDPI)202642784019PubTator, text miningPubMed
Familial short stature: genetic architecture, risk stratification, and precision management.Front Endocrinol (Lausanne)202642713069PubTator, text miningPubMed
Precision medicine in pediatric growth disorders: Integrating clinical phenotype, genetics, IGF-1 biology and artificial intelligence: A systematic scoping review of PubMed-indexed literature (2000-2026).
Growth Horm IGF Res202642628320PubTator, text miningPubMed
Langer mesomelic dysplasia as a rare manifestation of SHOX deficiency: a narrative review.Front Genet202642553923PubTator, text miningPubMed
Integrated cardiac, endocrine, and genetic assessment in adolescent basketball players.Front Endocrinol (Lausanne)202642548527PubTator, text miningPubMed
Combined optical genome mapping and cnv-seq identify complex Y-chromosome rearrangements and ectopy in 46,XX testicular disorder of sex development.Mol Cytogenet202642289734PubTator, text miningPubMed
Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study.Eur J Pediatr202642243538PubTator, text miningPubMed
A qPCR-based algorithm for the diagnosis of classic and non-classic Turner syndrome.Indian J Med Res202642237825PubTator, text miningPubMed
GLI1-fusion neoplasm of the tongue: report of a pediatric case associated with SHOX deficiency disorder.Virchows Arch202642159714PubTator, text miningPubMed

1 to 10 of 1,180

See all 1,180 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6473

GET https://conductscience.org/api/genes/v1/6473/patents?page=2