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Gene · 64750

SMURF2: SMAD specific E3 ubiquitin protein ligase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMURF2: SMAD specific E3 ubiquitin protein ligase 2. Genes, record 64750. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64750

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Gene

Symbol
SMURF2
HGNC
Name
SMAD specific E3 ubiquitin protein ligase 2
HGNC
NCBI Gene ID
64750
NCBI Gene
HGNC ID
HGNC:16809
HGNC
Ensembl
ENSG00000108854
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HAU4E3 ubiquitin-protein ligase SMURF27488Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509876 A2026-03-2527Q9HAU4Espacenet
EP 4650780 A22025-11-192071Q9HAU4Espacenet
JP 2025532963 A2025-10-0327Q9HAU4Espacenet
EP 4593805 A22025-08-0627Q9HAU4Espacenet
JP 2025517970 A2025-06-122071Q9HAU4Espacenet
EP 4540277 A22025-04-2327Q9HAU4Espacenet
EP 4493157 A22025-01-2230Q9HAU4Espacenet
US 11827910 B22023-11-2811Q9HAU4Espacenet
JP 2023546156 A2023-11-0146Q9HAU4Espacenet
JP 2023545827 A2023-10-3144Q9HAU4Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants922

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMURF2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
ZIABC010419Molecular Mechanisms of TGF-beta Signaling Pathway52025
ZIABC011168Physiological and pathological functions of E3 ubiquitin ligases Smurfs52025
P30CA008748Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
P30CA068485Cancer Center Support Grant42025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025
R01DK057819Intestinal Mucosal Growth in Health and Surgical Diseases32025
UL1TR001863Yale Clinical and Translational Science Award32025

1 to 10 of 922Source NIH's project files

See all 922 nih grants

Papers1,626

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
FOXO6 inhibits SMURF2-mediated ubiquitination and degradation of NR4A1 to promote retinal pigment epithelial cell ferroptosis in diabetic retinopathy.J Cell Commun Signal202642656923PubTator, text miningPubMed
Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases.Cancer Lett202642641867PubTator, text miningPubMed
YAP1 lactylation confers cisplatin resistance and prognostic value by suppressing ferroptosis via FOSL1 in bladder cancer.Cell Rep202642455680PubTator, text miningPubMed
HECT E3 ubiquitin ligase SMURF2 orchestrates FcεRI-dependent mast cell activation and allergic responses.J Allergy Clin Immunol202642285366PubTator, text miningPubMed
ENO1 lactylation drives bevacizumab resistance through metabolic reprogramming and angiogenesis in ovarian cancer.Drug Resist Updat202642134086PubTator, text miningPubMed
ADCY7 dictates N-cadherin stability to inhibit HCC metastasis.JHEP Rep202642096912PubTator, text miningPubMed
Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model.J Vis Exp202642081362PubTator, text miningPubMed
The Small Chemical Compound Repsox Potentiates Oct4-Driven Astrocyte-to-Neural Stem Cell Reprogramming via Notch1/Hes1/Smurf2 Pathway.Cell Mol Neurobiol202642029832PubTator, text miningPubMed
Rare coding variants from ADSP R5 whole-genome sequencing implicate novel genes in Alzheimer's disease.Res Sq202641960309PubTator, text miningPubMed
In vivo CRISPR/Cas9 Screening Reveals that UBE2L3 Modulates Autophagic Flux through TSC2 Ubiquitination and Potentiates PD-1 Blockade in Triple-Negative Breast Cancer.Int J Biol Sci202641943836PubTator, text miningPubMed

1 to 10 of 1,626

See all 1,626 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/64750

GET https://conductscience.org/api/genes/v1/64750/patents?page=2