Gene · 64750
SMURF2: SMAD specific E3 ubiquitin protein ligase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMURF2: SMAD specific E3 ubiquitin protein ligase 2. Genes, record 64750. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64750
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9HAU4 | E3 ubiquitin-protein ligase SMURF2 | 748 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026509876 A | 2026-03-25 | 27 | Q9HAU4 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2071 | Q9HAU4 | Espacenet |
| JP 2025532963 A | 2025-10-03 | 27 | Q9HAU4 | Espacenet |
| EP 4593805 A2 | 2025-08-06 | 27 | Q9HAU4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2071 | Q9HAU4 | Espacenet |
| EP 4540277 A2 | 2025-04-23 | 27 | Q9HAU4 | Espacenet |
| EP 4493157 A2 | 2025-01-22 | 30 | Q9HAU4 | Espacenet |
| US 11827910 B2 | 2023-11-28 | 11 | Q9HAU4 | Espacenet |
| JP 2023546156 A | 2023-11-01 | 46 | Q9HAU4 | Espacenet |
| JP 2023545827 A | 2023-10-31 | 44 | Q9HAU4 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants922
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMURF2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| ZIABC010419 | Molecular Mechanisms of TGF-beta Signaling Pathway | 5 | 2025 |
| ZIABC011168 | Physiological and pathological functions of E3 ubiquitin ligases Smurfs | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30CA142543 | UT Southwestern Medical Center Simmons Comprehensive Cancer Center | 3 | 2025 |
| R01DK057819 | Intestinal Mucosal Growth in Health and Surgical Diseases | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
1 to 10 of 922Source NIH's project files
See all 922 nih grantsPapers1,626
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| FOXO6 inhibits SMURF2-mediated ubiquitination and degradation of NR4A1 to promote retinal pigment epithelial cell ferroptosis in diabetic retinopathy. | J Cell Commun Signal | 2026 | 42656923 | PubTator, text mining | PubMed |
| Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases. | Cancer Lett | 2026 | 42641867 | PubTator, text mining | PubMed |
| YAP1 lactylation confers cisplatin resistance and prognostic value by suppressing ferroptosis via FOSL1 in bladder cancer. | Cell Rep | 2026 | 42455680 | PubTator, text mining | PubMed |
| HECT E3 ubiquitin ligase SMURF2 orchestrates FcεRI-dependent mast cell activation and allergic responses. | J Allergy Clin Immunol | 2026 | 42285366 | PubTator, text mining | PubMed |
| ENO1 lactylation drives bevacizumab resistance through metabolic reprogramming and angiogenesis in ovarian cancer. | Drug Resist Updat | 2026 | 42134086 | PubTator, text mining | PubMed |
| ADCY7 dictates N-cadherin stability to inhibit HCC metastasis. | JHEP Rep | 2026 | 42096912 | PubTator, text mining | PubMed |
| Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model. | J Vis Exp | 2026 | 42081362 | PubTator, text mining | PubMed |
| The Small Chemical Compound Repsox Potentiates Oct4-Driven Astrocyte-to-Neural Stem Cell Reprogramming via Notch1/Hes1/Smurf2 Pathway. | Cell Mol Neurobiol | 2026 | 42029832 | PubTator, text mining | PubMed |
| Rare coding variants from ADSP R5 whole-genome sequencing implicate novel genes in Alzheimer's disease. | Res Sq | 2026 | 41960309 | PubTator, text mining | PubMed |
| In vivo CRISPR/Cas9 Screening Reveals that UBE2L3 Modulates Autophagic Flux through TSC2 Ubiquitination and Potentiates PD-1 Blockade in Triple-Negative Breast Cancer. | Int J Biol Sci | 2026 | 41943836 | PubTator, text mining | PubMed |
1 to 10 of 1,626
See all 1,626 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/64750
GET https://conductscience.org/api/genes/v1/64750/patents?page=2