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SI: sucrase-isomaltase

1 protein, 17 patents, 2 drugs, 19 trials, 1,241 NIH grants and 12,356 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSIHGNC
Namesucrase-isomaltaseHGNC
NCBI Gene ID6476NCBI Gene
HGNC IDHGNC:10856HGNC
EnsemblENSG00000090402NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P14410Sucrase-isomaltase, intestinal1,8272Ensembl, GeneID, HGNCUniProt

Patents 17

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026185138 A12026-09-101P14410Espacenet
JP 2026004568 A2026-01-1465718P14410Espacenet
EP 4641201 A22025-10-291914P14410Espacenet
JP 2025529142 A2025-09-043949P14410Espacenet
US 12371689 B22025-07-293949P14410Espacenet
JP 2025517969 A2025-06-121914P14410Espacenet
EP 4547856 A22025-05-07343P14410Espacenet
JP 2022141755 A2022-09-2939P14410Espacenet
US 11446398 B22022-09-2084804P14410Espacenet
US 11400116 B22022-08-02767P14410Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CELGOSIVIRCHEMBL2110737Alpha glucosidase inhibitorINHIBITORChEMBL
VOGLIBOSECHEMBL476960Alpha glucosidase inhibitorINHIBITORChEMBL

Trials 19

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05688332VOGLIBOSEPHASE3ClinicalTrials.gov
NCT02569827CELGOSIVIRPHASE1/PHASE2ClinicalTrials.gov
NCT02097342VOGLIBOSEPHASE4ClinicalTrials.gov
NCT02049814VOGLIBOSEPHASE42019-02-04ClinicalTrials.gov
NCT01619969CELGOSIVIRPHASE1/PHASE2ClinicalTrials.gov
NCT01309698VOGLIBOSEPHASE4ClinicalTrials.gov
NCT01263509VOGLIBOSEPHASE2/PHASE32011-08-29ClinicalTrials.gov
NCT01263496VOGLIBOSEPHASE22011-07-07ClinicalTrials.gov
NCT01263483VOGLIBOSEPHASE2/PHASE32011-07-11ClinicalTrials.gov
NCT01263470VOGLIBOSEPHASE22011-07-06ClinicalTrials.gov

NIH grants 1241

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK056338Texas Medical Center Digestive Diseases Center142,025NIH's project files
R01DK067859Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity92,025NIH's project files
ZIAHG200336Genetic and clinical studies of Gaucher disease and other lysosomal disorders92,025NIH's project files
P30DK036836Diabetes Research Center82,025NIH's project files
U19AI116497Human Biomimetics for Mucosal Infections72,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology62,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease62,025NIH's project files
P20GM103430Rhode Island IDeA Network of Biomedical Research Excellence52,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52,025NIH's project files

Papers 12356

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824724PubTator, text miningPubMed
42824679PubTator, text miningPubMed
42822561PubTator, text miningPubMed
42820986PubTator, text miningPubMed
42819881PubTator, text miningPubMed
42818855PubTator, text miningPubMed
42818763PubTator, text miningPubMed
42816978PubTator, text miningPubMed
42815095PubTator, text miningPubMed
42814340PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license