Gene · 6477
SIAH1: siah E3 ubiquitin protein ligase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SIAH1: siah E3 ubiquitin protein ligase 1. Genes, record 6477. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6477
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8IUQ4 | E3 ubiquitin-protein ligase SIAH1 | 282 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 10249 | Q8IUQ4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 10249 | Q8IUQ4 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8364 | Q8IUQ4 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 1985 | Q8IUQ4 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 2487 | Q8IUQ4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78860 | Q8IUQ4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78861 | Q8IUQ4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 78862 | Q8IUQ4 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 181831 | Q8IUQ4 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 181832 | Q8IUQ4 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants779
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SIAH1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA019014 | Viral Oncogenesis, Latency, and Replication | 4 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P50AA024337 | The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury | 4 | 2025 |
| P20GM103436 | IDeA Networks of Biomedical Research Excellence in Kentucky | 3 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| I01BX002670 | Telomere attrition and T cell aging in vaccine failure during HIV infection | 2 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 2 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 779Source NIH's project files
See all 779 nih grantsPapers1,284
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SIAH1-Mediated Ubiquitination and Degradation of TRIB3 Modulate Osteogenic and Adipogenic Differentiation. | Stem Cells Int | 2026 | 42662480 | PubTator, text mining | PubMed |
| The autoimmune regulator (AIRE) is a target of the E3-Ubiquitin ligase Seven-in-absentia homolog 1 (SIAH1). | Apoptosis | 2026 | 42449076 | PubTator, text mining | PubMed |
| p300 Degradation by the p53-SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity. | Adv Sci (Weinh) | 2026 | 42294752 | PubTator, text mining | PubMed |
| Polyubiquitination and accumulation of PEG10 regulated by SIAH1/2 affiliates the progression of hepatocellular carcinoma. | Cell Commun Signal | 2026 | 42168988 | PubTator, text mining | PubMed |
| Implication of Epigenetic Alterations of ZEB1 in Colorectal Cancer (CRC) Pathogenesis and Therapy Development. | Curr Issues Mol Biol | 2026 | 41899428 | PubTator, text mining | PubMed |
| TSG101 Promotes SIAH1 Auto-Ubiquitination to Drive Migration and Invasion in Hepatocellular Carcinoma Cells. | J Cell Mol Med | 2026 | 41872127 | PubTator, text mining | PubMed |
| O-GlcNAcylation of IGF2BP2 promotes angiogenesis after ischemic stroke by stabilizing PPP2CA in an m6A-dependent manner : O-GlcNAcylation of IGF2BP2 alleviates ischemic brain injury. | J Transl Med | 2026 | 41832533 | PubTator, text mining | PubMed |
| Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma Cells. | Oncol Res | 2026 | 41799511 | PubTator, text mining | PubMed |
| Laryngeal squamous cell carcinoma: a functional "two-hit" model of papillomavirus-Epstein-Barr virus synergistic carcinogenesis. | Front Cell Infect Microbiol | 2026 | 41798741 | PubTator, text mining | PubMed |
| Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases. | Epigenetics | 2026 | 41778387 | PubTator, text mining | PubMed |
1 to 10 of 1,284
See all 1,284 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6477
GET https://conductscience.org/api/genes/v1/6477/patents?page=2