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Gene · 6477

SIAH1: siah E3 ubiquitin protein ligase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SIAH1: siah E3 ubiquitin protein ligase 1. Genes, record 6477. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6477

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Gene

Symbol
SIAH1
HGNC
Name
siah E3 ubiquitin protein ligase 1
HGNC
NCBI Gene ID
6477
NCBI Gene
HGNC ID
HGNC:10857
HGNC
Ensembl
ENSG00000196470
NCBI Gene
Aliases
BURHAS, SIAH1A, hSIAH1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IUQ4E3 ubiquitin-protein ligase SIAH128210Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910249Q8IUQ4Espacenet
JP 2025517970 A2025-06-1210249Q8IUQ4Espacenet
JP 2024123008 A2024-09-108364Q8IUQ4Espacenet
US 11708396 B22023-07-251985Q8IUQ4Espacenet
US 11708396 B22023-07-252487Q8IUQ4Espacenet
US 11446398 B22022-09-2078860Q8IUQ4Espacenet
US 11446398 B22022-09-2078861Q8IUQ4Espacenet
US 11446398 B22022-09-2078862Q8IUQ4Espacenet
JP 2022524081 A2022-04-27181831Q8IUQ4Espacenet
JP 2022524081 A2022-04-27181832Q8IUQ4Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants779

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIAH1 papersNewest fiscal year
P01CA019014Viral Oncogenesis, Latency, and Replication42025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA068485Cancer Center Support Grant42025
P50AA024337The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury42025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky32025
P30CA006973Regional Oncology Research Center32025
I01BX002670Telomere attrition and T cell aging in vaccine failure during HIV infection22025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025

1 to 10 of 779Source NIH's project files

See all 779 nih grants

Papers1,284

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SIAH1-Mediated Ubiquitination and Degradation of TRIB3 Modulate Osteogenic and Adipogenic Differentiation.Stem Cells Int202642662480PubTator, text miningPubMed
The autoimmune regulator (AIRE) is a target of the E3-Ubiquitin ligase Seven-in-absentia homolog 1 (SIAH1).Apoptosis202642449076PubTator, text miningPubMed
p300 Degradation by the p53-SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity.Adv Sci (Weinh)202642294752PubTator, text miningPubMed
Polyubiquitination and accumulation of PEG10 regulated by SIAH1/2 affiliates the progression of hepatocellular carcinoma.Cell Commun Signal202642168988PubTator, text miningPubMed
Implication of Epigenetic Alterations of ZEB1 in Colorectal Cancer (CRC) Pathogenesis and Therapy Development.Curr Issues Mol Biol202641899428PubTator, text miningPubMed
TSG101 Promotes SIAH1 Auto-Ubiquitination to Drive Migration and Invasion in Hepatocellular Carcinoma Cells.J Cell Mol Med202641872127PubTator, text miningPubMed
O-GlcNAcylation of IGF2BP2 promotes angiogenesis after ischemic stroke by stabilizing PPP2CA in an m6A-dependent manner : O-GlcNAcylation of IGF2BP2 alleviates ischemic brain injury.J Transl Med202641832533PubTator, text miningPubMed
Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma Cells.Oncol Res202641799511PubTator, text miningPubMed
Laryngeal squamous cell carcinoma: a functional "two-hit" model of papillomavirus-Epstein-Barr virus synergistic carcinogenesis.Front Cell Infect Microbiol202641798741PubTator, text miningPubMed
Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases.Epigenetics202641778387PubTator, text miningPubMed

1 to 10 of 1,284

See all 1,284 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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