Gene · 64798
DEPTOR: DEP domain containing MTOR interacting protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DEPTOR: DEP domain containing MTOR interacting protein. Genes, record 64798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64798
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8TB45 | DEP domain-containing mTOR-interacting protein | 409 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 43649 | Q8TB45 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3281 | Q8TB45 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2855 | Q8TB45 | Espacenet |
| WO 2025199077 A1 | 2025-09-25 | 164 | Q8TB45 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2855 | Q8TB45 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3281 | Q8TB45 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 23984 | Q8TB45 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 126955 | Q8TB45 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3015 | Q8TB45 | Espacenet |
| KR 1020200064974 A | 2020-06-08 | 2 | Q8TB45 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,181
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DEPTOR papers | Newest fiscal year |
|---|---|---|---|
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| T32AI007247 | Cellular and Molecular Mechanisms of Immune Inflammatory Reactions | 5 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 4 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 4 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 4 | 2025 |
| I01CX000916 | Signaling Pathways and Therapeutic Targeting of Leukemic Cells | 3 | 2025 |
1 to 10 of 1,181Source NIH's project files
See all 1,181 nih grantsPapers1,775
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Phosphorylation of OTUB1 promotes autophagy initiation under starvation. | Nat Commun | 2026 | 42736303 | PubTator, text mining | PubMed |
| Retraction: A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity. | Mol Cancer Ther | 2026 | 42548210 | PubTator, text mining | PubMed |
| Retraction: Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells. | Cancer Res | 2026 | 42452978 | PubTator, text mining | PubMed |
| Screening Biomarkers Related to Circadian Rhythm of Gastric Cancer Through Bioinformatics. | Appl Biochem Biotechnol | 2026 | 42287537 | PubTator, text mining | PubMed |
| Computational investigation of biochanin a targeting DEPTOR in Alzheimer's disease with in vitro cellular validation of neuroprotective activity. | Sci Rep | 2026 | 41963454 | PubTator, text mining | PubMed |
| Overlapping genetic etiology of pediatric and adult germ cell tumors. | J Natl Cancer Inst | 2026 | 41941753 | PubTator, text mining | PubMed |
| Tear Biomarkers of Topical Sirolimus in Meibomian Gland Dysfunction: A Randomized Trial. | Clin Ophthalmol | 2026 | 41929713 | PubTator, text mining | PubMed |
| Time-Restricted Eating, Cardiometabolic Health in Obesity and The Optimal Length of the Eating Window. | Curr Nutr Rep | 2026 | 41801605 | PubTator, text mining | PubMed |
| Molecular mechanisms and therapeutic targeting implications of ER/mTOR signaling axis-driven tumor progression in aggressive meningiomas. | Transl Oncol | 2026 | 41794007 | PubTator, text mining | PubMed |
| Integrated multi-omics profiling to dissect the development of second primary lung cancer in laryngeal cancer: An observational study. | Medicine (Baltimore) | 2026 | 41790655 | PubTator, text mining | PubMed |
1 to 10 of 1,775
See all 1,775 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/64798
GET https://conductscience.org/api/genes/v1/64798/patents