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Gene · 64798

DEPTOR: DEP domain containing MTOR interacting protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DEPTOR: DEP domain containing MTOR interacting protein. Genes, record 64798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64798

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Gene

Symbol
DEPTOR
HGNC
Name
DEP domain containing MTOR interacting protein
HGNC
NCBI Gene ID
64798
NCBI Gene
HGNC ID
HGNC:22953
HGNC
Ensembl
ENSG00000155792
NCBI Gene
Aliases
DEP.6, DEPDC6, FLJ12428, hDEPTOR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8TB45DEP domain-containing mTOR-interacting protein4099Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443649Q8TB45Espacenet
EP 4650780 A22025-11-193281Q8TB45Espacenet
EP 4641201 A22025-10-292855Q8TB45Espacenet
WO 2025199077 A12025-09-25164Q8TB45Espacenet
JP 2025517969 A2025-06-122855Q8TB45Espacenet
JP 2025517970 A2025-06-123281Q8TB45Espacenet
US 11446398 B22022-09-2023984Q8TB45Espacenet
JP 2022524081 A2022-04-27126955Q8TB45Espacenet
US 11078247 B22021-08-033015Q8TB45Espacenet
KR 1020200064974 A2020-06-082Q8TB45Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,181

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDEPTOR papersNewest fiscal year
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes82025
P30CA008748Cancer Center Support Grant72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
P30CA016672Cancer Center Support Grant52025
T32AI007247Cellular and Molecular Mechanisms of Immune Inflammatory Reactions52025
P30CA014520UW Comprehensive Cancer Center Support42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
P30CA076292Moffitt Cancer Center Support Grant42025
I01CX000916Signaling Pathways and Therapeutic Targeting of Leukemic Cells32025

1 to 10 of 1,181Source NIH's project files

See all 1,181 nih grants

Papers1,775

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phosphorylation of OTUB1 promotes autophagy initiation under starvation.Nat Commun202642736303PubTator, text miningPubMed
Retraction: A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity.Mol Cancer Ther202642548210PubTator, text miningPubMed
Retraction: Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells.Cancer Res202642452978PubTator, text miningPubMed
Screening Biomarkers Related to Circadian Rhythm of Gastric Cancer Through Bioinformatics.Appl Biochem Biotechnol202642287537PubTator, text miningPubMed
Computational investigation of biochanin a targeting DEPTOR in Alzheimer's disease with in vitro cellular validation of neuroprotective activity.Sci Rep202641963454PubTator, text miningPubMed
Overlapping genetic etiology of pediatric and adult germ cell tumors.J Natl Cancer Inst202641941753PubTator, text miningPubMed
Tear Biomarkers of Topical Sirolimus in Meibomian Gland Dysfunction: A Randomized Trial.Clin Ophthalmol202641929713PubTator, text miningPubMed
Time-Restricted Eating, Cardiometabolic Health in Obesity and The Optimal Length of the Eating Window.Curr Nutr Rep202641801605PubTator, text miningPubMed
Molecular mechanisms and therapeutic targeting implications of ER/mTOR signaling axis-driven tumor progression in aggressive meningiomas.Transl Oncol202641794007PubTator, text miningPubMed
Integrated multi-omics profiling to dissect the development of second primary lung cancer in laryngeal cancer: An observational study.Medicine (Baltimore)202641790655PubTator, text miningPubMed

1 to 10 of 1,775

See all 1,775 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/64798

GET https://conductscience.org/api/genes/v1/64798/patents