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Gene · 6480

ST6GAL1: ST6 beta-galactoside alpha-2,6-sialyltransferase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ST6GAL1: ST6 beta-galactoside alpha-2,6-sialyltransferase 1. Genes, record 6480. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6480

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Gene

Symbol
ST6GAL1
HGNC
Name
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
HGNC
NCBI Gene ID
6480
NCBI Gene
HGNC ID
HGNC:10860
HGNC
Ensembl
ENSG00000073849
NCBI Gene
Aliases
CDw75, SIAT1, ST6GalI, ST6N
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P15907Beta-galactoside alpha-2,6-sialyltransferase 14064Ensembl, GeneID, HGNC

Source UniProt

Patents217

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4807367 A22026-09-1628P15907Espacenet
EP 4774376 A12026-07-151P15907Espacenet
JP 2026053486 A2026-03-253P15907Espacenet
US 12516094 B22026-01-068P15907Espacenet
EP 4650780 A22025-11-19139P15907Espacenet
EP 4636080 A12025-10-229P15907Espacenet
JP 2025147176 A2025-10-0612883P15907Espacenet
JP 2025147176 A2025-10-0612884P15907Espacenet
JP 2025530569 A2025-09-113P15907Espacenet
JP 2025529142 A2025-09-047816P15907Espacenet

1 to 10 of 217

See all 217 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,029

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleST6GAL1 papersNewest fiscal year
P30CA013148Comprehensive Cancer Center Support Grant102025
P30CA016056Roswell Park Cancer Center Support Grant102025
R01GM083144Characterization of mammalian COG complex-interacting Golgi trafficking machinery102025
P30AI027767UAB Center for AIDS Research (CFAR)82025
R01HL103411Systems Biology of Glycosylation62025
P01HL151333Molecular and Clinical Glycobiology of the Bone Marrow Environment42025
P30CA016087Cancer Center Support Grant42025
R01GM115234Regulatory Mechanisms of Glycoprotein Sialylation42025
R35GM119850Unraveling the mammalian secretory pathway through systems biology and algorithm development42025
T32AI089474Immunology Training Program-Predoctoral42025

1 to 10 of 1,029Source NIH's project files

See all 1,029 nih grants

Papers1,665

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Epigenetic Regulation of Sialyltransferase ST6GAL1 Drives Breast Tumor Heterogeneity.Cancers (Basel)202642794954PubTator, text miningPubMed
ST6GAL1 promotes cancer stem-like cell-associated paclitaxel resistance through the EGFR-mTOR-SOX2/BMI1 axis in non-small cell lung cancer.Cancer Drug Resist202642764906PubTator, text miningPubMed
GOLPH3-mediated sialylation of CXCR4 drives malignant progression and M2 macrophage polarization in colorectal cancer.Apoptosis202642749929PubTator, text miningPubMed
Integrin β3 α2,6-sialylation by the sialyltransferase ST6Gal1 promotes human cytomegalovirus entry into fibroblasts.Virulence202642725794PubTator, text miningPubMed
B3GNT5-associated glycosylation remodeling in tumor-associated macrophages supports TGF-β-related glioma progression.Biochim Biophys Acta Gen Subj202642715804PubTator, text miningPubMed
Enhanced sialylation of bone marrow mesenchymal stromal cells contributes to immune remodeling through macrophage polarization in multiple myeloma patients.Front Immunol202642712628PubTator, text miningPubMed
Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458-Based ST6GAL1 Inhibitors Enhance Membrane Permeability.ChemMedChem202642647183PubTator, text miningPubMed
ST6GAL1 Is a Functional Regulator of UVA-Induced Photoaging in Human Dermal Fibroblasts.Cells202642645226PubTator, text miningPubMed
ST6GAL1-mediated sialyl linkage switching drives cancer-promoting α2,6-sialo-protrusions radiating from anti-inflammatory TAMs.Proc Natl Acad Sci U S A202642640786PubTator, text miningPubMed
Shared glycosylation-related molecular mechanism and immune infiltration patterns of fetal growth restriction and preeclampsia.Front Immunol202642564306PubTator, text miningPubMed

1 to 10 of 1,665

See all 1,665 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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