Gene · 6480
ST6GAL1: ST6 beta-galactoside alpha-2,6-sialyltransferase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ST6GAL1: ST6 beta-galactoside alpha-2,6-sialyltransferase 1. Genes, record 6480. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6480
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P15907 | Beta-galactoside alpha-2,6-sialyltransferase 1 | 406 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents217
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4807367 A2 | 2026-09-16 | 28 | P15907 | Espacenet |
| EP 4774376 A1 | 2026-07-15 | 1 | P15907 | Espacenet |
| JP 2026053486 A | 2026-03-25 | 3 | P15907 | Espacenet |
| US 12516094 B2 | 2026-01-06 | 8 | P15907 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 139 | P15907 | Espacenet |
| EP 4636080 A1 | 2025-10-22 | 9 | P15907 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 12883 | P15907 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 12884 | P15907 | Espacenet |
| JP 2025530569 A | 2025-09-11 | 3 | P15907 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7816 | P15907 | Espacenet |
1 to 10 of 217
See all 217 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,029
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ST6GAL1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA013148 | Comprehensive Cancer Center Support Grant | 10 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 10 | 2025 |
| R01GM083144 | Characterization of mammalian COG complex-interacting Golgi trafficking machinery | 10 | 2025 |
| P30AI027767 | UAB Center for AIDS Research (CFAR) | 8 | 2025 |
| R01HL103411 | Systems Biology of Glycosylation | 6 | 2025 |
| P01HL151333 | Molecular and Clinical Glycobiology of the Bone Marrow Environment | 4 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 4 | 2025 |
| R01GM115234 | Regulatory Mechanisms of Glycoprotein Sialylation | 4 | 2025 |
| R35GM119850 | Unraveling the mammalian secretory pathway through systems biology and algorithm development | 4 | 2025 |
| T32AI089474 | Immunology Training Program-Predoctoral | 4 | 2025 |
1 to 10 of 1,029Source NIH's project files
See all 1,029 nih grantsPapers1,665
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Epigenetic Regulation of Sialyltransferase ST6GAL1 Drives Breast Tumor Heterogeneity. | Cancers (Basel) | 2026 | 42794954 | PubTator, text mining | PubMed |
| ST6GAL1 promotes cancer stem-like cell-associated paclitaxel resistance through the EGFR-mTOR-SOX2/BMI1 axis in non-small cell lung cancer. | Cancer Drug Resist | 2026 | 42764906 | PubTator, text mining | PubMed |
| GOLPH3-mediated sialylation of CXCR4 drives malignant progression and M2 macrophage polarization in colorectal cancer. | Apoptosis | 2026 | 42749929 | PubTator, text mining | PubMed |
| Integrin β3 α2,6-sialylation by the sialyltransferase ST6Gal1 promotes human cytomegalovirus entry into fibroblasts. | Virulence | 2026 | 42725794 | PubTator, text mining | PubMed |
| B3GNT5-associated glycosylation remodeling in tumor-associated macrophages supports TGF-β-related glioma progression. | Biochim Biophys Acta Gen Subj | 2026 | 42715804 | PubTator, text mining | PubMed |
| Enhanced sialylation of bone marrow mesenchymal stromal cells contributes to immune remodeling through macrophage polarization in multiple myeloma patients. | Front Immunol | 2026 | 42712628 | PubTator, text mining | PubMed |
| Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458-Based ST6GAL1 Inhibitors Enhance Membrane Permeability. | ChemMedChem | 2026 | 42647183 | PubTator, text mining | PubMed |
| ST6GAL1 Is a Functional Regulator of UVA-Induced Photoaging in Human Dermal Fibroblasts. | Cells | 2026 | 42645226 | PubTator, text mining | PubMed |
| ST6GAL1-mediated sialyl linkage switching drives cancer-promoting α2,6-sialo-protrusions radiating from anti-inflammatory TAMs. | Proc Natl Acad Sci U S A | 2026 | 42640786 | PubTator, text mining | PubMed |
| Shared glycosylation-related molecular mechanism and immune infiltration patterns of fetal growth restriction and preeclampsia. | Front Immunol | 2026 | 42564306 | PubTator, text mining | PubMed |
1 to 10 of 1,665
See all 1,665 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6480
GET https://conductscience.org/api/genes/v1/6480/patents?page=2