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P2RY12: purinergic receptor P2Y12

1 protein, 74 patents, 18 drugs, 647 trials, 2,788 NIH grants and 7,712 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolP2RY12HGNC
Namepurinergic receptor P2Y12HGNC
NCBI Gene ID64805NCBI Gene
HGNC IDHGNC:18124HGNC
EnsemblENSG00000169313NCBI Gene
AliasesADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9H244P2Y purinoceptor 123425Ensembl, GeneID, HGNCUniProt

Patents 74

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1460484Q9H244Espacenet
EP 4650780 A22025-11-194484Q9H244Espacenet
EP 4641201 A22025-10-294029Q9H244Espacenet
JP 2025529142 A2025-09-043322Q9H244Espacenet
US 12371689 B22025-07-293322Q9H244Espacenet
JP 2025517969 A2025-06-124029Q9H244Espacenet
JP 2025517970 A2025-06-124484Q9H244Espacenet
JP 2025087820 A2025-06-1056Q9H244Espacenet
JP 2025032204 A2025-03-1132815Q9H244Espacenet
EP 4461818 A22024-11-1332815Q9H244Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CANGRELORCHEMBL334966Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
CANGRELORCHEMBL334966Purinergic receptor P2Y12 inhibitorINHIBITORChEMBL
CANGRELOR TETRASODIUMCHEMBL1097279Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
CLOPIDOGRELCHEMBL1771Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
CLOPIDOGREL BESILATECHEMBL6068333Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
CLOPIDOGREL BISULFATECHEMBL1083385Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
CLOPIDOGREL HYDROBROMIDECHEMBL6068343Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
CLOPIDOGREL HYDROCHLORIDECHEMBL6068338Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
ELINOGRELCHEMBL2103828Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL
PRASUGRELCHEMBL1201772Purinergic receptor P2Y12 antagonistANTAGONISTChEMBL

Trials 647

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07597239CLOPIDOGRELClinicalTrials.gov
NCT07597239TICAGRELORClinicalTrials.gov
NCT07583784CLOPIDOGRELClinicalTrials.gov
NCT07512960CLOPIDOGRELPHASE3ClinicalTrials.gov
NCT07511257CLOPIDOGRELPHASE4ClinicalTrials.gov
NCT07432516CLOPIDOGRELClinicalTrials.gov
NCT07432516TICAGRELORClinicalTrials.gov
NCT07195149PRASUGRELPHASE3ClinicalTrials.gov
NCT07169513CLOPIDOGRELClinicalTrials.gov
NCT06916520PRASUGRELPHASE4ClinicalTrials.gov

NIH grants 2788

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIADK031116Development of P2Y Receptor Ligands502,025NIH's project files
ZIADK031126Computer Modeling of G Protein-Coupled Receptors212,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award132,025NIH's project files
R01NS088137Targeting TGFb/IFNy-IRF8 Signaling to Modulate Monocytes and their Crosstalk with Microglia and Astrocytes to Treat Multiple Sclerosis122,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI112,025NIH's project files
ZIADK031117Development of Drugs Acting at Adenosine Receptors102,025NIH's project files
P30CA016672Cancer Center Support Grant92,025NIH's project files
U54MD007600Center for Collaborative Research in Health Disparities92,025NIH's project files
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health82,025NIH's project files
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy72,025NIH's project files

Papers 7712

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824965PubTator, text miningPubMed
42822103PubTator, text miningPubMed
42822087PubTator, text miningPubMed
42821875PubTator, text miningPubMed
42819776PubTator, text miningPubMed
42809927PubTator, text miningPubMed
42786908PubTator, text miningPubMed
42778156PubTator, text miningPubMed
42772061PubTator, text miningPubMed
42770881PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license