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Gene · 64816

CYP3A43: cytochrome P450 family 3 subfamily A member 43

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP3A43: cytochrome P450 family 3 subfamily A member 43. Genes, record 64816. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64816

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Gene

Symbol
CYP3A43
HGNC
Name
cytochrome P450 family 3 subfamily A member 43
HGNC
NCBI Gene ID
64816
NCBI Gene
HGNC ID
HGNC:17450
HGNC
Ensembl
ENSG00000021461
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9HB55Cytochrome P450 3A435030Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442915Q9HB55Espacenet
EP 4641201 A22025-10-297002Q9HB55Espacenet
JP 2025529142 A2025-09-041191Q9HB55Espacenet
US 12371689 B22025-07-291191Q9HB55Espacenet
JP 2025517969 A2025-06-127002Q9HB55Espacenet
US 11446398 B22022-09-2022056Q9HB55Espacenet
US 11400116 B22022-08-025575Q9HB55Espacenet
JP 2022524081 A2022-04-27125027Q9HB55Espacenet
JP 2019054813 A2019-04-11223350Q9HB55Espacenet
JP 2017121241 A2017-07-13223350Q9HB55Espacenet

1 to 10 of 17

See all 17 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COBICISTATCHEMBL2095208Cytochrome P450 3A inhibitorINHIBITORChEMBL
RITONAVIRCHEMBL163Cytochrome P450 3A inhibitorINHIBITORChEMBL

Trials513

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants359

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP3A43 papersNewest fiscal year
R35GM140845Expression genetics of pharmacogenes42025
R35GM118041Regulation of xenobiotic receptors PXR and CAR, and CYP3A: implications in drug disposition32025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30CA022453CANCER CENTER SUPPORT GRANT22025
P30DK026743UCSF Liver Center22025
T32GM066691Clinical Pharmacology Training Program22025
T32HD069038Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology22025
U54AG065181IUSM TREAT-AD Center22025
U54OD030167UAB Center for Precision Animal Modeling (CPAM)22025
ZIABC005562Xenobiotic receptors22025

1 to 10 of 359Source NIH's project files

See all 359 nih grants

Papers374

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial.JCO Precis Oncol202642628007PubTator, text miningPubMed
Side effects in hypertension treatment: a pharmacogenomic analysis.Eur Heart J202642545033PubTator, text miningPubMed
Integrative Machine Learning Model for Overall Survival Prediction in Breast Cancer Using Clinical and Transcriptomic Data.Biology (Basel)202541300329PubTator, text miningPubMed
Impact of per- and polyfluoroalkyl substances on diabetic kidney disease.Front Endocrinol (Lausanne)202540995593PubTator, text miningPubMed
Androgen production, uptake, and conversion (APUC) genes define prostate cancer patients with distinct clinical outcomes.JCI Insight202439207857PubTator, text miningPubMed
Molecular Factors Predicting Ovarian Chemotoxicity in Fertile Women: A Systematic Review.Cancers (Basel)202439199566PubTator, text miningPubMed
Ionic Liquid 1-Octyl-3-Methylimidazolium (M8OI) Is Mono-Oxygenated by CYP3A4 and CYP3A5 in Adult Human Liver.J Xenobiot202439051346PubTator, text miningPubMed
COVID-19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples.Br J Clin Pharmacol202438817198PubTator, text miningPubMed
Signatures of Co-evolution and Co-regulation in the CYP3A and CYP4F Genes in Humans.Genome Biol Evol202438207129PubTator, text miningPubMed
TYROBP as a molecular target in cholangiocarcinoma, renal cancer and abdominal aortic aneurysm.Medicine (Baltimore)202438181271PubTator, text miningPubMed

1 to 10 of 374

See all 374 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/64816

GET https://conductscience.org/api/genes/v1/64816/patents