Gene · 64848
YTHDC2: YTH N6-methyladenosine RNA binding protein C2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. YTHDC2: YTH N6-methyladenosine RNA binding protein C2. Genes, record 64848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64848
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H6S0 | 3'-5' RNA helicase YTHDC2 | 1,430 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 120 | Q9H6S0 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 98 | Q9H6S0 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 98 | Q9H6S0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 120 | Q9H6S0 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 17396 | Q9H6S0 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 771 | Q9H6S0 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 98260 | Q9H6S0 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 201231 | Q9H6S0 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 12717 | Q9H6S0 | Espacenet |
| EP 3504344 A1 | 2019-07-03 | 1572 | Q9H6S0 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants390
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | YTHDC2 papers | Newest fiscal year |
|---|---|---|---|
| RM1HG008935 | Center for dynamic RNA epitranscriptomes - Renewal | 6 | 2025 |
| R01CA186702 | Mechanisms of epitranscriptomic regulation in cancer | 5 | 2025 |
| P20GM113226 | Hepatobiology and Toxicology COBRE | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 3 | 2025 |
| P30ES027792 | ChicAgo Center for Health and EnvironmenT (CACHET) | 3 | 2025 |
| R01AI125416 | Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection | 3 | 2025 |
| R35NS111631 | New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons | 3 | 2025 |
| P20GM103436 | IDeA Networks of Biomedical Research Excellence in Kentucky | 2 | 2025 |
| P30AG067988 | Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional) | 2 | 2025 |
1 to 10 of 390Source NIH's project files
See all 390 nih grantsPapers1,809
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| ACTB promotes ESCC progression by regulating the AKT-mTOR signaling pathway through an m6A-dependent mechanism. | Oncogene | 2026 | 42816548 | PubTator, text mining | PubMed |
| H3K27me3 loss and METTL3-m6A converge to upregulate SOX11/SMARCA4 and drive H3K27-altered spinal cord glioma stemness and proliferation. | Neuro Oncol | 2026 | 42804733 | PubTator, text mining | PubMed |
| ALKBH5-Dependent m6A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration. | Circulation | 2026 | 42770216 | PubTator, text mining | PubMed |
| Development of m6A-related prognostic models for survival in lung squamous cell carcinoma with different PD-L1 expression levels. | Transl Cancer Res | 2026 | 42724890 | PubTator, text mining | PubMed |
| The m6A Reader YTHDC2: Molecular Mechanisms and Regulatory Networks in Disease Pathogenesis. | Cells | 2026 | 42645195 | PubTator, text mining | PubMed |
| Expression of m6A Reader Protein YTHDC2 in Non-small Cell Lung Cancer in a Chinese Clinical Cohort. | J Vis Exp | 2026 | 42611590 | PubTator, text mining | PubMed |
| N6-Methyladenosine-Driven Nuclear Export of circKCNN2 Impairs GRP75 Function to Promote Neuronal Apoptosis. | Mol Neurobiol | 2026 | 42496794 | PubTator, text mining | PubMed |
| Molecular genetics of meiotic initiation in mammals. | Biol Reprod | 2026 | 42479652 | PubTator, text mining | PubMed |
| YTHDC2 suppresses oral squamous cell carcinoma progression by inhibiting glutaminolysis via VHL/HIF-1α axis. | Int J Biol Macromol | 2026 | 42372894 | PubTator, text mining | PubMed |
| Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2-m6A-Dependent KDR/VEGFA Loop. | Adv Sci (Weinh) | 2026 | 42334038 | PubTator, text mining | PubMed |
1 to 10 of 1,809
See all 1,809 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/64848
GET https://conductscience.org/api/genes/v1/64848/patents