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Gene · 64848

YTHDC2: YTH N6-methyladenosine RNA binding protein C2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. YTHDC2: YTH N6-methyladenosine RNA binding protein C2. Genes, record 64848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/64848

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Gene

Symbol
YTHDC2
HGNC
Name
YTH N6-methyladenosine RNA binding protein C2
HGNC
NCBI Gene ID
64848
NCBI Gene
HGNC ID
HGNC:24721
HGNC
Ensembl
ENSG00000047188
NCBI Gene
Aliases
CAHL, DKFZp564A186, FLJ10053, FLJ2194, hYTHDC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H6S03'-5' RNA helicase YTHDC21,4306Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19120Q9H6S0Espacenet
EP 4641201 A22025-10-2998Q9H6S0Espacenet
JP 2025517969 A2025-06-1298Q9H6S0Espacenet
JP 2025517970 A2025-06-12120Q9H6S0Espacenet
JP 2025024198 A2025-02-1917396Q9H6S0Espacenet
JP 2022141755 A2022-09-29771Q9H6S0Espacenet
US 11446398 B22022-09-2098260Q9H6S0Espacenet
JP 2022524081 A2022-04-27201231Q9H6S0Espacenet
US 11078247 B22021-08-0312717Q9H6S0Espacenet
EP 3504344 A12019-07-031572Q9H6S0Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants390

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleYTHDC2 papersNewest fiscal year
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal62025
R01CA186702Mechanisms of epitranscriptomic regulation in cancer52025
P20GM113226Hepatobiology and Toxicology COBRE32025
P30CA008748Cancer Center Support Grant32025
P30CA014599Cancer Center Support Grant32025
P30ES027792ChicAgo Center for Health and EnvironmenT (CACHET)32025
R01AI125416Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection32025
R35NS111631New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons32025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025
P30AG067988Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional)22025

1 to 10 of 390Source NIH's project files

See all 390 nih grants

Papers1,809

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ACTB promotes ESCC progression by regulating the AKT-mTOR signaling pathway through an m6A-dependent mechanism.Oncogene202642816548PubTator, text miningPubMed
H3K27me3 loss and METTL3-m6A converge to upregulate SOX11/SMARCA4 and drive H3K27-altered spinal cord glioma stemness and proliferation.Neuro Oncol202642804733PubTator, text miningPubMed
ALKBH5-Dependent m6A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration.Circulation202642770216PubTator, text miningPubMed
Development of m6A-related prognostic models for survival in lung squamous cell carcinoma with different PD-L1 expression levels.Transl Cancer Res202642724890PubTator, text miningPubMed
The m6A Reader YTHDC2: Molecular Mechanisms and Regulatory Networks in Disease Pathogenesis.Cells202642645195PubTator, text miningPubMed
Expression of m6A Reader Protein YTHDC2 in Non-small Cell Lung Cancer in a Chinese Clinical Cohort.J Vis Exp202642611590PubTator, text miningPubMed
N6-Methyladenosine-Driven Nuclear Export of circKCNN2 Impairs GRP75 Function to Promote Neuronal Apoptosis.Mol Neurobiol202642496794PubTator, text miningPubMed
Molecular genetics of meiotic initiation in mammals.Biol Reprod202642479652PubTator, text miningPubMed
YTHDC2 suppresses oral squamous cell carcinoma progression by inhibiting glutaminolysis via VHL/HIF-1α axis.Int J Biol Macromol202642372894PubTator, text miningPubMed
Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2-m6A-Dependent KDR/VEGFA Loop.Adv Sci (Weinh)202642334038PubTator, text miningPubMed

1 to 10 of 1,809

See all 1,809 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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