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PMEL: premelanosome protein

1 protein, 299 patents, 2 drugs, 16 trials, 2,814 NIH grants and 4,932 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolPMELHGNC
Namepremelanosome proteinHGNC
NCBI Gene ID6490NCBI Gene
HGNC IDHGNC:10880HGNC
EnsemblENSG00000185664NCBI Gene
AliasesD12S53E, HMB-45, HMB45, ME20, ME20-M, ME20M, P1, P100, PMEL17, Pmel17, SI, SIL, SILV, gp100NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P40967Melanocyte protein PMEL66120Ensembl, GeneID, HGNCUniProt

Patents 299

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4824265 A12026-10-2117P40967Espacenet
WO 2026022310 A12026-01-2917P40967Espacenet
EP 4650780 A22025-11-1916494P40967Espacenet
EP 4641201 A22025-10-2920314P40967Espacenet
JP 2025147176 A2025-10-0610562P40967Espacenet
JP 2025147176 A2025-10-0610563P40967Espacenet
JP 2025147176 A2025-10-0610564P40967Espacenet
JP 2025138725 A2025-09-253395P40967Espacenet
JP 2025138725 A2025-09-253397P40967Espacenet
JP 2025138725 A2025-09-253436P40967Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IMC-GP100CHEMBL2109434Melanocyte protein PMEL cross-linking agentCROSS-LINKING AGENTChEMBL
TEBENTAFUSPCHEMBL4297990Melanocyte protein PMEL binding agentBINDING AGENTChEMBL

Trials 16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07276386TEBENTAFUSPPHASE2ClinicalTrials.gov
NCT07063875TEBENTAFUSPPHASE1/PHASE2ClinicalTrials.gov
NCT07057596TEBENTAFUSPPHASE2ClinicalTrials.gov
NCT06942442TEBENTAFUSPPHASE2ClinicalTrials.gov
NCT06627244TEBENTAFUSPPHASE2ClinicalTrials.gov
NCT06626516TEBENTAFUSPPHASE1/PHASE2ClinicalTrials.gov
NCT06414590TEBENTAFUSPPHASE2ClinicalTrials.gov
NCT06070012TEBENTAFUSPPHASE2ClinicalTrials.gov
NCT05549297TEBENTAFUSPPHASE3ClinicalTrials.gov
NCT04960891TEBENTAFUSPClinicalTrials.gov

NIH grants 2814

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant782,025NIH's project files
P30CA016672Cancer Center Support Grant672,025NIH's project files
ZIABC010984Adoptive Cell Transfer Immunotherapy of Cancer482,025NIH's project files
ZIABC010985Gene therapy of cancer302,025NIH's project files
P30CA044579University of Virginia Cancer Center Support Grant222,025NIH's project files
P30CA047904Cancer Center Support Grant222,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program202,025NIH's project files
ZIAHL002541Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)192,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant182,025NIH's project files
P01CA163222Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment172,025NIH's project files

Papers 4932

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42788773PubTator, text miningPubMed
42720426PubTator, text miningPubMed
42687870PubTator, text miningPubMed
42594873PubTator, text miningPubMed
42465753PubTator, text miningPubMed
42443515PubTator, text miningPubMed
42331227PubTator, text miningPubMed
42163062PubTator, text miningPubMed
42159443PubTator, text miningPubMed
42112367PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license