Gene · 6495
SIX1: SIX homeobox 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SIX1: SIX homeobox 1. Genes, record 6495. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6495
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15475 | Homeobox protein SIX1 | 284 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026048885 A | 2026-03-05 | 11 | Q15475 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 63674 | Q15475 | Espacenet |
| WO 2025248252 A1 | 2025-12-04 | 54 | Q15475 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19423 | Q15475 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15612 | Q15475 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19423 | Q15475 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15612 | Q15475 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15612 | Q15475 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15451 | Q15475 | Espacenet |
| US 12023330 B2 | 2024-07-02 | 1 | Q15475 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,231
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SIX1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA046934 | University of Colorado Cancer Center Support Grant | 25 | 2025 |
| R01EY022305 | NEIGHBORHOOD Consortium for POAG Genetics | 13 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| R01DK064640 | Transcription factors in kidney development | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| R01EY013178 | Novel Glaucoma Diagnostics for Structure and Function. | 7 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 6 | 2025 |
| U10CA180886 | COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement | 6 | 2025 |
1 to 10 of 1,231Source NIH's project files
See all 1,231 nih grantsPapers2,008
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Branchio-oto-renal syndrome: a narrative review. | Child Kidney Dis | 2026 | 42779651 | PubTator, text mining | PubMed |
| SIX1 drives acute myeloid leukemia progression by reprogramming glycolytic metabolism and impairing CD8⁺ T-cell effector function. | Immunol Res | 2026 | 42693356 | PubTator, text mining | PubMed |
| Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer. | Front Genet | 2026 | 42670482 | PubTator, text mining | PubMed |
| The GCN5L2-SIX1 complex drives glycolysis to promote progression of triple-negative breast cancer. | Cancer Lett | 2026 | 42601012 | PubTator, text mining | PubMed |
| Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axis. | iScience | 2026 | 42571403 | PubTator, text mining | PubMed |
| SIX1 is required for adult cochlear sensory epithelium homeostasis and auditory function. | Proc Natl Acad Sci U S A | 2026 | 42546190 | PubTator, text mining | PubMed |
| GRP78 Drives NSCLC Stemness and EMT via a SIX1/β-Catenin Signaling Axis. | Drug Dev Res | 2026 | 42546137 | PubTator, text mining | PubMed |
| Context-dependent regulation of SIX1 by ETS1 within EMT-associated transcriptional networks. | Turk J Biol | 2026 | 42500691 | PubTator, text mining | PubMed |
| Direct and indirect regulation of SIX1+EYA transcriptional activity by PA2G4, MCRS1, and SOBP. | Tissue Cell | 2026 | 42475796 | PubTator, text mining | PubMed |
| Genetic Diagnosis of Non-Syndromic Hearing Loss in South Indian Consanguineous Families Using Whole-Exome Sequencing. | Medicina (Kaunas) | 2026 | 42356053 | PubTator, text mining | PubMed |
1 to 10 of 2,008
See all 2,008 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6495
GET https://conductscience.org/api/genes/v1/6495/patents?page=2