ConductScience.org, home

Gene · 6495

SIX1: SIX homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SIX1: SIX homeobox 1. Genes, record 6495. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6495

On this page

Gene

Symbol
SIX1
HGNC
Name
SIX homeobox 1
HGNC
NCBI Gene ID
6495
NCBI Gene
HGNC ID
HGNC:10887
HGNC
Ensembl
ENSG00000126778
NCBI Gene
Aliases
BOS3, DFNA23, TIP39
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15475Homeobox protein SIX12841Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026048885 A2026-03-0511Q15475Espacenet
JP 2026004568 A2026-01-1463674Q15475Espacenet
WO 2025248252 A12025-12-0454Q15475Espacenet
EP 4650780 A22025-11-1919423Q15475Espacenet
JP 2025147176 A2025-10-0615612Q15475Espacenet
JP 2025517970 A2025-06-1219423Q15475Espacenet
JP 2025028160 A2025-02-2815612Q15475Espacenet
KR 1020250010750 A2025-01-2115612Q15475Espacenet
JP 2024109657 A2024-08-1415451Q15475Espacenet
US 12023330 B22024-07-021Q15475Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,231

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSIX1 papersNewest fiscal year
P30CA046934University of Colorado Cancer Center Support Grant252025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics132025
P30EY014104P30 Core Grant for Vision Research122025
P30CA016672Cancer Center Support Grant92025
R01DK064640Transcription factors in kidney development92025
P30CA008748Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)82025
R01EY013178Novel Glaucoma Diagnostics for Structure and Function.72025
P30EY005722Center Core Grant for Vision Research62025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement62025

1 to 10 of 1,231Source NIH's project files

See all 1,231 nih grants

Papers2,008

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Branchio-oto-renal syndrome: a narrative review.Child Kidney Dis202642779651PubTator, text miningPubMed
SIX1 drives acute myeloid leukemia progression by reprogramming glycolytic metabolism and impairing CD8⁺ T-cell effector function.Immunol Res202642693356PubTator, text miningPubMed
Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer.Front Genet202642670482PubTator, text miningPubMed
The GCN5L2-SIX1 complex drives glycolysis to promote progression of triple-negative breast cancer.Cancer Lett202642601012PubTator, text miningPubMed
Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axis.iScience202642571403PubTator, text miningPubMed
SIX1 is required for adult cochlear sensory epithelium homeostasis and auditory function.Proc Natl Acad Sci U S A202642546190PubTator, text miningPubMed
GRP78 Drives NSCLC Stemness and EMT via a SIX1/β-Catenin Signaling Axis.Drug Dev Res202642546137PubTator, text miningPubMed
Context-dependent regulation of SIX1 by ETS1 within EMT-associated transcriptional networks.Turk J Biol202642500691PubTator, text miningPubMed
Direct and indirect regulation of SIX1+EYA transcriptional activity by PA2G4, MCRS1, and SOBP.Tissue Cell202642475796PubTator, text miningPubMed
Genetic Diagnosis of Non-Syndromic Hearing Loss in South Indian Consanguineous Families Using Whole-Exome Sequencing.Medicina (Kaunas)202642356053PubTator, text miningPubMed

1 to 10 of 2,008

See all 2,008 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6495

GET https://conductscience.org/api/genes/v1/6495/patents?page=2