Gene · 6507
SLC1A3: solute carrier family 1 member 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC1A3: solute carrier family 1 member 3. Genes, record 6507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6507
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P43003 | Excitatory amino acid transporter 1 | 542 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63940 | P43003 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2444 | P43003 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2027 | P43003 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4041 | P43003 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4041 | P43003 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2027 | P43003 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2444 | P43003 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29020 | P43003 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29027 | P43003 | Espacenet |
| US 12156890 B2 | 2024-12-03 | 59 | P43003 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants3,217
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC1A3 papers | Newest fiscal year |
|---|---|---|---|
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 35 | 2025 |
| R01ES007331 | Mechanisms of Methylmercury Induced Neuronal Toxicity | 14 | 2025 |
| ZIAAG000975 | ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders | 9 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 8 | 2025 |
| ZIAMH002946 | Structure, Function and Pharmacology of Neurotransmitter Reuptake Systems | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| R24HD000836 | Laboratory of Developmental Biology | 6 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 5 | 2025 |
| U54MD007582 | FAMU Center for Health Disparities Research | 5 | 2025 |
| U54MD007586 | The RCMI Program in Health Disparities Research at Meharry Medical College | 5 | 2025 |
1 to 10 of 3,217Source NIH's project files
See all 3,217 nih grantsPapers3,986
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| EAAT1 sustains redox homeostasis and temozolomide resistance through glutamate-dependent regulation of the Keap1/Nrf2 axis in glioblastoma. | Exp Neurol | 2027 | 42668078 | PubTator, text mining | PubMed |
| Paired RNA profiling of circulating small extracellular vesicles links survival in ALS to reactive glial - vascular programs. | bioRxiv | 2026 | 42779744 | PubTator, text mining | PubMed |
| Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG). | bioRxiv | 2026 | 42779592 | PubTator, text mining | PubMed |
| Multi-omics integration and colocalization analyses prioritize candidate molecular loci associated with hypothermia. | J Therm Biol | 2026 | 42753640 | PubTator, text mining | PubMed |
| Synergistic apoptotic induction in acute lymphoblastic leukemia cells: exploring the role of EAAT1 inhibition by UCPH-101 in combination with asparaginase. | Mol Biol Rep | 2026 | 42566094 | PubTator, text mining | PubMed |
| Machine learning, WGCNA and molecular docking identify SLC transporter genes as biomarkers and drug targets in Helicobacter pylori-associated carcinogenesis. | Bioorg Chem | 2026 | 42520516 | PubTator, text mining | PubMed |
| Maternal copper levels moderate the neuroprotective effect of zinc on early childhood development: evidence from a birth cohort and proteomic profiling. | Front Nutr | 2026 | 42516235 | PubTator, text mining | PubMed |
| Functional and Transcriptional Downregulation of Glutamate Transporters (EAAT1 and EAAT2) via DNMT3B Overexpression in Glial Cells. | Mol Neurobiol | 2026 | 42496779 | PubTator, text mining | PubMed |
| Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progression. | Acta Neuropathol Commun | 2026 | 42477819 | PubTator, text mining | PubMed |
| Skin-innervating glutamatergic neurons modulate aging. | Cell | 2026 | 42468523 | PubTator, text mining | PubMed |
1 to 10 of 3,986
See all 3,986 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6507
GET https://conductscience.org/api/genes/v1/6507/patents?page=2