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Gene · 6507

SLC1A3: solute carrier family 1 member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC1A3: solute carrier family 1 member 3. Genes, record 6507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6507

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Gene

Symbol
SLC1A3
HGNC
Name
solute carrier family 1 member 3
HGNC
NCBI Gene ID
6507
NCBI Gene
HGNC ID
HGNC:10941
HGNC
Ensembl
ENSG00000079215
NCBI Gene
Aliases
EA6, EAAT1, GLAST, GLAST-1, GLAST1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43003Excitatory amino acid transporter 15425Ensembl, GeneID, HGNC

Source UniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463940P43003Espacenet
EP 4650780 A22025-11-192444P43003Espacenet
EP 4641201 A22025-10-292027P43003Espacenet
JP 2025529142 A2025-09-044041P43003Espacenet
US 12371689 B22025-07-294041P43003Espacenet
JP 2025517969 A2025-06-122027P43003Espacenet
JP 2025517970 A2025-06-122444P43003Espacenet
JP 2025032204 A2025-03-1129020P43003Espacenet
JP 2025032204 A2025-03-1129027P43003Espacenet
US 12156890 B22024-12-0359P43003Espacenet

1 to 10 of 51

See all 51 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants3,217

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC1A3 papersNewest fiscal year
R01ES010563Mechanisms of Manganese Neurotoxicity352025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity142025
ZIAAG000975ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders92025
R28AA012725Brain Tissue Resource Center for Alcohol Research82025
ZIAMH002946Structure, Function and Pharmacology of Neurotransmitter Reuptake Systems82025
P30CA008748Cancer Center Support Grant72025
R24HD000836Laboratory of Developmental Biology62025
P30CA091842Cancer Center Support Grant52025
U54MD007582FAMU Center for Health Disparities Research52025
U54MD007586The RCMI Program in Health Disparities Research at Meharry Medical College52025

1 to 10 of 3,217Source NIH's project files

See all 3,217 nih grants

Papers3,986

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
EAAT1 sustains redox homeostasis and temozolomide resistance through glutamate-dependent regulation of the Keap1/Nrf2 axis in glioblastoma.Exp Neurol202742668078PubTator, text miningPubMed
Paired RNA profiling of circulating small extracellular vesicles links survival in ALS to reactive glial - vascular programs.bioRxiv202642779744PubTator, text miningPubMed
Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG).bioRxiv202642779592PubTator, text miningPubMed
Multi-omics integration and colocalization analyses prioritize candidate molecular loci associated with hypothermia.J Therm Biol202642753640PubTator, text miningPubMed
Synergistic apoptotic induction in acute lymphoblastic leukemia cells: exploring the role of EAAT1 inhibition by UCPH-101 in combination with asparaginase.Mol Biol Rep202642566094PubTator, text miningPubMed
Machine learning, WGCNA and molecular docking identify SLC transporter genes as biomarkers and drug targets in Helicobacter pylori-associated carcinogenesis.Bioorg Chem202642520516PubTator, text miningPubMed
Maternal copper levels moderate the neuroprotective effect of zinc on early childhood development: evidence from a birth cohort and proteomic profiling.Front Nutr202642516235PubTator, text miningPubMed
Functional and Transcriptional Downregulation of Glutamate Transporters (EAAT1 and EAAT2) via DNMT3B Overexpression in Glial Cells.Mol Neurobiol202642496779PubTator, text miningPubMed
Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progression.Acta Neuropathol Commun202642477819PubTator, text miningPubMed
Skin-innervating glutamatergic neurons modulate aging.Cell202642468523PubTator, text miningPubMed

1 to 10 of 3,986

See all 3,986 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6507

GET https://conductscience.org/api/genes/v1/6507/patents?page=2