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Gene · 6523

SLC5A1: solute carrier family 5 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC5A1: solute carrier family 5 member 1. Genes, record 6523. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6523

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Gene

Symbol
SLC5A1
HGNC
Name
solute carrier family 5 member 1
HGNC
NCBI Gene ID
6523
NCBI Gene
HGNC ID
HGNC:11036
HGNC
Ensembl
ENSG00000100170
NCBI Gene
Aliases
D22S675, NAGT, SGLT-1, SGLT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P13866Sodium/glucose cotransporter 16644Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026513237 A2026-04-2336P13866Espacenet
JP 2026004568 A2026-01-1464738P13866Espacenet
EP 4641201 A22025-10-292147P13866Espacenet
JP 2025529142 A2025-09-044265P13866Espacenet
US 12371689 B22025-07-294265P13866Espacenet
JP 2025517969 A2025-06-122147P13866Espacenet
WO 2024258820 A22024-12-19363P13866Espacenet
JP 2024102286 A2024-07-3094P13866Espacenet
JP 2022179925 A2022-12-069P13866Espacenet
US 11446398 B22022-09-2081950P13866Espacenet

1 to 10 of 43

See all 43 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
LICOGLIFLOZINCHEMBL4297625Sodium/glucose cotransporter 1 inhibitorINHIBITORChEMBL
SOTAGLIFLOZINCHEMBL3039507Sodium/glucose cotransporter 1 inhibitorINHIBITORChEMBL

Trials46

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07594145SOTAGLIFLOZINPHASE2ClinicalTrials.gov
NCT07325201SOTAGLIFLOZINPHASE2ClinicalTrials.gov
NCT07211802SOTAGLIFLOZINPHASE3ClinicalTrials.gov
NCT06933056SOTAGLIFLOZINEARLY_PHASE1ClinicalTrials.gov
NCT06481891SOTAGLIFLOZINPHASE3ClinicalTrials.gov
NCT06435156SOTAGLIFLOZINPHASE2ClinicalTrials.gov
NCT06433050SOTAGLIFLOZINEARLY_PHASE1ClinicalTrials.gov
NCT06217302SOTAGLIFLOZINPHASE3ClinicalTrials.gov
NCT05696366SOTAGLIFLOZINPHASE1/PHASE2ClinicalTrials.gov
NCT05562063SOTAGLIFLOZINPHASE4ClinicalTrials.gov

1 to 10 of 46

See all 46 trials

NIH grants1,334

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC5A1 papersNewest fiscal year
R01DK112042Glomerular and Tubular Function in the Diabetic Kidney172025
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation112025
P30DK056338Texas Medical Center Digestive Diseases Center92025
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.92025
P30DK034854Integrated Epithelial and Muscosal Biology82025
P30DK058404Molecular and Cellular Basis for Digestive Diseases82025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)72025
RC2DK118640COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository72025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)62025
R01AI080656Regulation of Rotavirus Replication62025

1 to 10 of 1,334Source NIH's project files

See all 1,334 nih grants

Papers3,836

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Glucose Transporters: Structure, Trafficking, Physiology, and Disease Relevance.Curr Issues Mol Biol202642793217PubTator, text miningPubMed
The Nutraceutical Potential of Blackcurrant (Ribes nigrum) for Glycemic Control and Metabolic Health: Mechanistic and Translational Insights.Nutrients202642739024PubTator, text miningPubMed
Clinical Physiology of SGLT2 Inhibitors in Non-diabetic and Diabetic Individuals.Handb Exp Pharmacol202642730799PubTator, text miningPubMed
A single dose trial of mizagliflozin for the treatment of postbariatric hypoglycemia.J Endocr Soc202642670480PubTator, text miningPubMed
GLUT1/SGLT1 balance associates with high-glucose buffering of metformin-induced lysosomal deacidification and mTORC1 inhibition in colorectal cancer.Eur J Pharmacol202642628623PubTator, text miningPubMed
Multi-level aggregation analysis of microbiome composition and host gene expression reveals associations with systemic and local immunity.Microbiol Spectr202642573241PubTator, text miningPubMed
Uptake and Transport of Monotropein and Monotropein Esters in a Caco-2/HT29-MTX-E12 Co-Culture Model.Mol Nutr Food Res202642533546PubTator, text miningPubMed
Efficacy and Safety of the Dual SGLT1 and SGLT2 Inhibitor JP-2266 in Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study.Diabetes Metab J202642522372PubTator, text miningPubMed
Efficacy and Safety of SGLT2 Inhibitors and Sotagliflozin in Heart Failure: A Systematic Review and Meta-Analysis of 59 Randomized Controlled Trials.Cureus202642518892PubTator, text miningPubMed
Sodium-glucose cotransporter 1 exacerbates colon cancer malignancy by suppressing ferroptosis via the Nrf2/HO-1/SLC7A11/GPX4 axis under high glucose conditions.Arch Biochem Biophys202642492799PubTator, text miningPubMed

1 to 10 of 3,836

See all 3,836 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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