Gene · 6523
SLC5A1: solute carrier family 5 member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC5A1: solute carrier family 5 member 1. Genes, record 6523. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6523
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P13866 | Sodium/glucose cotransporter 1 | 664 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026513237 A | 2026-04-23 | 36 | P13866 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 64738 | P13866 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2147 | P13866 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4265 | P13866 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4265 | P13866 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2147 | P13866 | Espacenet |
| WO 2024258820 A2 | 2024-12-19 | 363 | P13866 | Espacenet |
| JP 2024102286 A | 2024-07-30 | 94 | P13866 | Espacenet |
| JP 2022179925 A | 2022-12-06 | 9 | P13866 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 81950 | P13866 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials46
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07594145 | SOTAGLIFLOZIN | PHASE2 | ClinicalTrials.gov | |
| NCT07325201 | SOTAGLIFLOZIN | PHASE2 | ClinicalTrials.gov | |
| NCT07211802 | SOTAGLIFLOZIN | PHASE3 | ClinicalTrials.gov | |
| NCT06933056 | SOTAGLIFLOZIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT06481891 | SOTAGLIFLOZIN | PHASE3 | ClinicalTrials.gov | |
| NCT06435156 | SOTAGLIFLOZIN | PHASE2 | ClinicalTrials.gov | |
| NCT06433050 | SOTAGLIFLOZIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT06217302 | SOTAGLIFLOZIN | PHASE3 | ClinicalTrials.gov | |
| NCT05696366 | SOTAGLIFLOZIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05562063 | SOTAGLIFLOZIN | PHASE4 | ClinicalTrials.gov |
1 to 10 of 46
See all 46 trialsNIH grants1,334
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC5A1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK112042 | Glomerular and Tubular Function in the Diabetic Kidney | 17 | 2025 |
| R01DK061931 | Mechanisms and pathophysiologic impact of claudin-2 modulation | 11 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 9 | 2025 |
| R01DK068271 | Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease. | 9 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 8 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 8 | 2025 |
| P30DK042086 | Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) | 7 | 2025 |
| RC2DK118640 | COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository | 7 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 6 | 2025 |
| R01AI080656 | Regulation of Rotavirus Replication | 6 | 2025 |
1 to 10 of 1,334Source NIH's project files
See all 1,334 nih grantsPapers3,836
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Glucose Transporters: Structure, Trafficking, Physiology, and Disease Relevance. | Curr Issues Mol Biol | 2026 | 42793217 | PubTator, text mining | PubMed |
| The Nutraceutical Potential of Blackcurrant (Ribes nigrum) for Glycemic Control and Metabolic Health: Mechanistic and Translational Insights. | Nutrients | 2026 | 42739024 | PubTator, text mining | PubMed |
| Clinical Physiology of SGLT2 Inhibitors in Non-diabetic and Diabetic Individuals. | Handb Exp Pharmacol | 2026 | 42730799 | PubTator, text mining | PubMed |
| A single dose trial of mizagliflozin for the treatment of postbariatric hypoglycemia. | J Endocr Soc | 2026 | 42670480 | PubTator, text mining | PubMed |
| GLUT1/SGLT1 balance associates with high-glucose buffering of metformin-induced lysosomal deacidification and mTORC1 inhibition in colorectal cancer. | Eur J Pharmacol | 2026 | 42628623 | PubTator, text mining | PubMed |
| Multi-level aggregation analysis of microbiome composition and host gene expression reveals associations with systemic and local immunity. | Microbiol Spectr | 2026 | 42573241 | PubTator, text mining | PubMed |
| Uptake and Transport of Monotropein and Monotropein Esters in a Caco-2/HT29-MTX-E12 Co-Culture Model. | Mol Nutr Food Res | 2026 | 42533546 | PubTator, text mining | PubMed |
| Efficacy and Safety of the Dual SGLT1 and SGLT2 Inhibitor JP-2266 in Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study. | Diabetes Metab J | 2026 | 42522372 | PubTator, text mining | PubMed |
| Efficacy and Safety of SGLT2 Inhibitors and Sotagliflozin in Heart Failure: A Systematic Review and Meta-Analysis of 59 Randomized Controlled Trials. | Cureus | 2026 | 42518892 | PubTator, text mining | PubMed |
| Sodium-glucose cotransporter 1 exacerbates colon cancer malignancy by suppressing ferroptosis via the Nrf2/HO-1/SLC7A11/GPX4 axis under high glucose conditions. | Arch Biochem Biophys | 2026 | 42492799 | PubTator, text mining | PubMed |
1 to 10 of 3,836
See all 3,836 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6523
GET https://conductscience.org/api/genes/v1/6523/patents?page=2