Gene · 6530
SLC6A2: solute carrier family 6 member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC6A2: solute carrier family 6 member 2. Genes, record 6530. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6530
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P23975 | Sodium-dependent noradrenaline transporter | 617 | 36 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64782 | P23975 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 64783 | P23975 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4286 | P23975 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4286 | P23975 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 82040 | P23975 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 82047 | P23975 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 785 | P23975 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 185011 | P23975 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 185018 | P23975 | Espacenet |
| US 11149254 B2 | 2021-10-19 | 127 | P23975 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs112
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMITIFADINE | CHEMBL592374 | Monoamine transporter inhibitor | INHIBITOR | ChEMBL |
| AMITRIPTYLINE | CHEMBL629 | Norepinephrine transporter inhibitor | INHIBITOR | ChEMBL |
| AMITRIPTYLINE HYDROCHLORIDE | CHEMBL1200964 | Norepinephrine transporter inhibitor | INHIBITOR | ChEMBL |
| AMOXAPINE | CHEMBL1113 | Norepinephrine transporter inhibitor | INHIBITOR | ChEMBL |
| AMPHETAMINE | CHEMBL405 | Norepinephrine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPHETAMINE ADIPATE | CHEMBL1200387 | Norepinephrine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPHETAMINE ASPARTATE | CHEMBL1200377 | Norepinephrine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPHETAMINE SULFATE | CHEMBL501 | Norepinephrine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPRELOXETINE | CHEMBL4297646 | Norepinephrine transporter inhibitor | INHIBITOR | ChEMBL |
| ATOMOXETINE | CHEMBL641 | Norepinephrine transporter inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 112
See all 112 drugsTrials1,737
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07596212 | BUPROPION | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07594652 | METHYLPHENIDATE HYDROCHLORIDE | PHASE4 | ClinicalTrials.gov | |
| NCT07588750 | SIBUTRAMINE | ClinicalTrials.gov | ||
| NCT07577661 | ATOMOXETINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07569159 | MIDOMAFETAMINE | PHASE2 | ClinicalTrials.gov | |
| NCT07556718 | AMITRIPTYLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07542145 | MIDOMAFETAMINE | PHASE1 | ClinicalTrials.gov | |
| NCT07533487 | DULOXETINE | ClinicalTrials.gov | ||
| NCT07533487 | MILNACIPRAN | ClinicalTrials.gov | ||
| NCT07527481 | NORTRIPTYLINE | ClinicalTrials.gov |
1 to 10 of 1,737
See all 1,737 trialsNIH grants2,396
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC6A2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 22 | 2025 |
| ZIANS003034 | Biomarkers of Catecholaminergic Neurodegeneration | 17 | 2025 |
| ZIADA000389 | Novel Probes for the Monoamine Transporters | 10 | 2025 |
| ZIADA000522 | Preclinical medication development for stimulant use disorder | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| ZIAAA000550 | Neurobiology of Drug Reward and Addiction | 6 | 2025 |
| ZIAMH002793 | PET Radiopharmaceutical Sciences | 6 | 2025 |
| ZIAMH002795 | Translational Evaluation of PET Radiotracers | 6 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 4 | 2025 |
| P51OD011106 | Wisconsin National Primate Research Center Support | 4 | 2025 |
1 to 10 of 2,396Source NIH's project files
See all 2,396 nih grantsPapers3,539
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Stereoselectivity of pleiotropic monoamine transporter 2-benzoylpiperidine inhibitors and their potential application as novel pharmacological tools. | Biochem Pharmacol | 2026 | 42800567 | PubTator, text mining | PubMed |
| Pupil size and pupil change correlate with distinct cortical neurochemical systems across the adult lifespan. | bioRxiv | 2026 | 42779750 | PubTator, text mining | PubMed |
| Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates. | Front Neurol | 2026 | 42755892 | PubTator, text mining | PubMed |
| Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis. | Front Immunol | 2026 | 42719741 | PubTator, text mining | PubMed |
| Characterization of Fish Serotonin, Dopamine and Norepinephrine Transporters as a Potential Target for Environmental Pharmaceuticals. | Environ Sci Technol | 2026 | 42708934 | PubTator, text mining | PubMed |
| hNET-targeted [18F]MFBG PET as baseline functional imaging in newly diagnosed neuroblastoma. | Theranostics | 2026 | 42708098 | PubTator, text mining | PubMed |
| Cognitive heterogeneity in major depressive disorder: Neuroimaging, transcriptomic, and neurotransmitter profiles. | Psychiatry Clin Neurosci | 2026 | 42704208 | PubTator, text mining | PubMed |
| Connectome Gradient-Based Subtyping of Major Depressive Disorder Reveals Distinct Neurobiological and Transcriptomic Signatures. | Depress Anxiety | 2026 | 42688891 | PubTator, text mining | PubMed |
| Cross-Cohort, Renal Compartment-Aware Transcriptomic Assessment of Lycii Fructus-Annotated Targets in Diabetic Kidney Disease. | Curr Issues Mol Biol | 2026 | 42651827 | PubTator, text mining | PubMed |
| Early glucagon-positive cells restrict pancreatic branching through VMAT2-noradrenaline-mediated ROS signaling. | Development | 2026 | 42643105 | PubTator, text mining | PubMed |
1 to 10 of 3,539
See all 3,539 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6530
GET https://conductscience.org/api/genes/v1/6530/patents?page=2