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Gene · 6530

SLC6A2: solute carrier family 6 member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC6A2: solute carrier family 6 member 2. Genes, record 6530. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6530

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Gene

Symbol
SLC6A2
HGNC
Name
solute carrier family 6 member 2
HGNC
NCBI Gene ID
6530
NCBI Gene
HGNC ID
HGNC:11048
HGNC
Ensembl
ENSG00000103546
NCBI Gene
Aliases
NAT1, NET, NET1, SLC6A5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23975Sodium-dependent noradrenaline transporter61736Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464782P23975Espacenet
JP 2026004568 A2026-01-1464783P23975Espacenet
JP 2025529142 A2025-09-044286P23975Espacenet
US 12371689 B22025-07-294286P23975Espacenet
US 11446398 B22022-09-2082040P23975Espacenet
US 11446398 B22022-09-2082047P23975Espacenet
US 11400116 B22022-08-02785P23975Espacenet
JP 2022524081 A2022-04-27185011P23975Espacenet
JP 2022524081 A2022-04-27185018P23975Espacenet
US 11149254 B22021-10-19127P23975Espacenet

1 to 10 of 46

See all 46 patents

Drugs112

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMITIFADINECHEMBL592374Monoamine transporter inhibitorINHIBITORChEMBL
AMITRIPTYLINECHEMBL629Norepinephrine transporter inhibitorINHIBITORChEMBL
AMITRIPTYLINE HYDROCHLORIDECHEMBL1200964Norepinephrine transporter inhibitorINHIBITORChEMBL
AMOXAPINECHEMBL1113Norepinephrine transporter inhibitorINHIBITORChEMBL
AMPHETAMINECHEMBL405Norepinephrine transporter releasing agentRELEASING AGENTChEMBL
AMPHETAMINE ADIPATECHEMBL1200387Norepinephrine transporter releasing agentRELEASING AGENTChEMBL
AMPHETAMINE ASPARTATECHEMBL1200377Norepinephrine transporter releasing agentRELEASING AGENTChEMBL
AMPHETAMINE SULFATECHEMBL501Norepinephrine transporter releasing agentRELEASING AGENTChEMBL
AMPRELOXETINECHEMBL4297646Norepinephrine transporter inhibitorINHIBITORChEMBL
ATOMOXETINECHEMBL641Norepinephrine transporter inhibitorINHIBITORChEMBL

1 to 10 of 112

See all 112 drugs

Trials1,737

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07596212BUPROPIONPHASE1/PHASE2ClinicalTrials.gov
NCT07594652METHYLPHENIDATE HYDROCHLORIDEPHASE4ClinicalTrials.gov
NCT07588750SIBUTRAMINEClinicalTrials.gov
NCT07577661ATOMOXETINEPHASE1/PHASE2ClinicalTrials.gov
NCT07569159MIDOMAFETAMINEPHASE2ClinicalTrials.gov
NCT07556718AMITRIPTYLINEPHASE2ClinicalTrials.gov
NCT07542145MIDOMAFETAMINEPHASE1ClinicalTrials.gov
NCT07533487DULOXETINEClinicalTrials.gov
NCT07533487MILNACIPRANClinicalTrials.gov
NCT07527481NORTRIPTYLINEClinicalTrials.gov

1 to 10 of 1,737

See all 1,737 trials

NIH grants2,396

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC6A2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant222025
ZIANS003034Biomarkers of Catecholaminergic Neurodegeneration172025
ZIADA000389Novel Probes for the Monoamine Transporters102025
ZIADA000522Preclinical medication development for stimulant use disorder82025
UL1TR001863Yale Clinical and Translational Science Award72025
ZIAAA000550Neurobiology of Drug Reward and Addiction62025
ZIAMH002793PET Radiopharmaceutical Sciences62025
ZIAMH002795Translational Evaluation of PET Radiotracers62025
P30ES019776HERCULES: Exposome Research Center42025
P51OD011106Wisconsin National Primate Research Center Support42025

1 to 10 of 2,396Source NIH's project files

See all 2,396 nih grants

Papers3,539

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Stereoselectivity of pleiotropic monoamine transporter 2-benzoylpiperidine inhibitors and their potential application as novel pharmacological tools.Biochem Pharmacol202642800567PubTator, text miningPubMed
Pupil size and pupil change correlate with distinct cortical neurochemical systems across the adult lifespan.bioRxiv202642779750PubTator, text miningPubMed
Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates.Front Neurol202642755892PubTator, text miningPubMed
Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis.Front Immunol202642719741PubTator, text miningPubMed
Characterization of Fish Serotonin, Dopamine and Norepinephrine Transporters as a Potential Target for Environmental Pharmaceuticals.Environ Sci Technol202642708934PubTator, text miningPubMed
hNET-targeted [18F]MFBG PET as baseline functional imaging in newly diagnosed neuroblastoma.Theranostics202642708098PubTator, text miningPubMed
Cognitive heterogeneity in major depressive disorder: Neuroimaging, transcriptomic, and neurotransmitter profiles.Psychiatry Clin Neurosci202642704208PubTator, text miningPubMed
Connectome Gradient-Based Subtyping of Major Depressive Disorder Reveals Distinct Neurobiological and Transcriptomic Signatures.Depress Anxiety202642688891PubTator, text miningPubMed
Cross-Cohort, Renal Compartment-Aware Transcriptomic Assessment of Lycii Fructus-Annotated Targets in Diabetic Kidney Disease.Curr Issues Mol Biol202642651827PubTator, text miningPubMed
Early glucagon-positive cells restrict pancreatic branching through VMAT2-noradrenaline-mediated ROS signaling.Development202642643105PubTator, text miningPubMed

1 to 10 of 3,539

See all 3,539 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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