SLC6A3: solute carrier family 6 member 3
1 protein, 108 patents, 45 drugs, 966 trials, 8,220 NIH grants and 17,500 papers.
Gene 7
Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.
Proteins 1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in | Source |
|---|---|---|---|---|---|
| Q01959 | Sodium-dependent dopamine transporter | 620 | 17 | Ensembl, GeneID, HGNC | UniProt |
Patents 108
Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64765 | Q01959 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 64766 | Q01959 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2326 | Q01959 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4288 | Q01959 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4288 | Q01959 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2326 | Q01959 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27098 | Q01959 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27099 | Q01959 | Espacenet |
| US 12240915 B2 | 2025-03-04 | 18 | Q01959 | Espacenet |
| US 12188096 B2 | 2025-01-07 | 58 | Q01959 | Espacenet |
Drugs 45
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMITIFADINE | CHEMBL592374 | Monoamine transporter inhibitor | INHIBITOR | ChEMBL |
| AMPHETAMINE | CHEMBL405 | Dopamine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPHETAMINE ADIPATE | CHEMBL1200387 | Dopamine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPHETAMINE ASPARTATE | CHEMBL1200377 | Dopamine transporter releasing agent | RELEASING AGENT | ChEMBL |
| AMPHETAMINE SULFATE | CHEMBL501 | Dopamine transporter releasing agent | RELEASING AGENT | ChEMBL |
| ARMODAFINIL | CHEMBL1201192 | Dopamine transporter inhibitor | INHIBITOR | ChEMBL |
| BICIFADINE | CHEMBL511099 | Monoamine transporter inhibitor | INHIBITOR | ChEMBL |
| BUPROPION | CHEMBL894 | Dopamine transporter inhibitor | INHIBITOR | ChEMBL |
| BUPROPION HYDROBROMIDE | CHEMBL1201735 | Dopamine transporter inhibitor | INHIBITOR | ChEMBL |
| BUPROPION HYDROCHLORIDE | CHEMBL1698 | Dopamine transporter inhibitor | INHIBITOR | ChEMBL |
Trials 966
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07596212 | BUPROPION | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07594652 | METHYLPHENIDATE HYDROCHLORIDE | PHASE4 | ClinicalTrials.gov | |
| NCT07588750 | SIBUTRAMINE | ClinicalTrials.gov | ||
| NCT07582458 | MODAFINIL | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07569159 | MIDOMAFETAMINE | PHASE2 | ClinicalTrials.gov | |
| NCT07542145 | MIDOMAFETAMINE | PHASE1 | ClinicalTrials.gov | |
| NCT07523048 | BUPROPION | PHASE2 | ClinicalTrials.gov | |
| NCT07490054 | METHYLPHENIDATE | PHASE1 | ClinicalTrials.gov | |
| NCT07398404 | BUPROPION | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07303907 | MIDOMAFETAMINE | PHASE2 | ClinicalTrials.gov |
NIH grants 8220
NIH projects whose papers are about the gene, through NIH's grant-paper links.
| Project | Title | Its papers about the gene | Newest fiscal year | Source |
|---|---|---|---|---|
| ZIAAA000550 | Neurobiology of Drug Reward and Addiction | 54 | 2,025 | NIH's project files |
| ZIADA000389 | Novel Probes for the Monoamine Transporters | 47 | 2,025 | NIH's project files |
| R01DA014204 | Regulation of Dopamine Transporter by Trafficking | 31 | 2,025 | NIH's project files |
| T32ES012870 | Graduate and Postdoctoral Training in Environmental Health Science and Toxicology | 31 | 2,025 | NIH's project files |
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 27 | 2,025 | NIH's project files |
| UL1TR001863 | Yale Clinical and Translational Science Award | 26 | 2,025 | NIH's project files |
| R01DA035714 | Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1Tat and cocaine | 21 | 2,025 | NIH's project files |
| T32AA007565 | Multidisciplinary Training in the Biology of Alcohol Addiction | 21 | 2,025 | NIH's project files |
| P30ES019776 | HERCULES: Exposome Research Center | 20 | 2,025 | NIH's project files |
| ZIADA000522 | Preclinical medication development for stimulant use disorder | 20 | 2,025 | NIH's project files |
Papers 17500
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| PMID | Found by | Source |
|---|---|---|
| 42807025 | PubTator, text mining | PubMed |
| 42805551 | PubTator, text mining | PubMed |
| 42805307 | PubTator, text mining | PubMed |
| 42800731 | PubTator, text mining | PubMed |
| 42800567 | PubTator, text mining | PubMed |
| 42797415 | PubTator, text mining | PubMed |
| 42795409 | PubTator, text mining | PubMed |
| 42778415 | PubTator, text mining | PubMed |
| 42776345 | PubTator, text mining | PubMed |
| 42768746 | PubTator, text mining | PubMed |
Release gene-search-2026-11-11-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
HGNC: CC0: https://www.genenames.org/about/license/
NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH's project files and grant-paper links: Public domain (NIH RePORTER)
Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubTator 3: Public domain
UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license