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SLC6A3: solute carrier family 6 member 3

1 protein, 108 patents, 45 drugs, 966 trials, 8,220 NIH grants and 17,500 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSLC6A3HGNC
Namesolute carrier family 6 member 3HGNC
NCBI Gene ID6531NCBI Gene
HGNC IDHGNC:11049HGNC
EnsemblENSG00000142319NCBI Gene
AliasesDAT, DAT1, PKDYS, PKDYS1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q01959Sodium-dependent dopamine transporter62017Ensembl, GeneID, HGNCUniProt

Patents 108

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464765Q01959Espacenet
JP 2026004568 A2026-01-1464766Q01959Espacenet
EP 4641201 A22025-10-292326Q01959Espacenet
JP 2025529142 A2025-09-044288Q01959Espacenet
US 12371689 B22025-07-294288Q01959Espacenet
JP 2025517969 A2025-06-122326Q01959Espacenet
JP 2025032204 A2025-03-1127098Q01959Espacenet
JP 2025032204 A2025-03-1127099Q01959Espacenet
US 12240915 B22025-03-0418Q01959Espacenet
US 12188096 B22025-01-0758Q01959Espacenet

Drugs 45

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMITIFADINECHEMBL592374Monoamine transporter inhibitorINHIBITORChEMBL
AMPHETAMINECHEMBL405Dopamine transporter releasing agentRELEASING AGENTChEMBL
AMPHETAMINE ADIPATECHEMBL1200387Dopamine transporter releasing agentRELEASING AGENTChEMBL
AMPHETAMINE ASPARTATECHEMBL1200377Dopamine transporter releasing agentRELEASING AGENTChEMBL
AMPHETAMINE SULFATECHEMBL501Dopamine transporter releasing agentRELEASING AGENTChEMBL
ARMODAFINILCHEMBL1201192Dopamine transporter inhibitorINHIBITORChEMBL
BICIFADINECHEMBL511099Monoamine transporter inhibitorINHIBITORChEMBL
BUPROPIONCHEMBL894Dopamine transporter inhibitorINHIBITORChEMBL
BUPROPION HYDROBROMIDECHEMBL1201735Dopamine transporter inhibitorINHIBITORChEMBL
BUPROPION HYDROCHLORIDECHEMBL1698Dopamine transporter inhibitorINHIBITORChEMBL

Trials 966

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07596212BUPROPIONPHASE1/PHASE2ClinicalTrials.gov
NCT07594652METHYLPHENIDATE HYDROCHLORIDEPHASE4ClinicalTrials.gov
NCT07588750SIBUTRAMINEClinicalTrials.gov
NCT07582458MODAFINILPHASE2/PHASE3ClinicalTrials.gov
NCT07569159MIDOMAFETAMINEPHASE2ClinicalTrials.gov
NCT07542145MIDOMAFETAMINEPHASE1ClinicalTrials.gov
NCT07523048BUPROPIONPHASE2ClinicalTrials.gov
NCT07490054METHYLPHENIDATEPHASE1ClinicalTrials.gov
NCT07398404BUPROPIONPHASE1/PHASE2ClinicalTrials.gov
NCT07303907MIDOMAFETAMINEPHASE2ClinicalTrials.gov

NIH grants 8220

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAAA000550Neurobiology of Drug Reward and Addiction542,025NIH's project files
ZIADA000389Novel Probes for the Monoamine Transporters472,025NIH's project files
R01DA014204Regulation of Dopamine Transporter by Trafficking312,025NIH's project files
T32ES012870Graduate and Postdoctoral Training in Environmental Health Science and Toxicology312,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity272,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
R01DA035714Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1Tat and cocaine212,025NIH's project files
T32AA007565Multidisciplinary Training in the Biology of Alcohol Addiction212,025NIH's project files
P30ES019776HERCULES: Exposome Research Center202,025NIH's project files
ZIADA000522Preclinical medication development for stimulant use disorder202,025NIH's project files

Papers 17500

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42807025PubTator, text miningPubMed
42805551PubTator, text miningPubMed
42805307PubTator, text miningPubMed
42800731PubTator, text miningPubMed
42800567PubTator, text miningPubMed
42797415PubTator, text miningPubMed
42795409PubTator, text miningPubMed
42778415PubTator, text miningPubMed
42776345PubTator, text miningPubMed
42768746PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license