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SLC6A4: solute carrier family 6 member 4

1 protein, 52 patents, 68 drugs, 1,665 trials, 8,060 NIH grants and 17,444 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSLC6A4HGNC
Namesolute carrier family 6 member 4HGNC
NCBI Gene ID6532NCBI Gene
HGNC IDHGNC:11050HGNC
EnsemblENSG00000108576NCBI Gene
Aliases5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERTNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P31645Sodium-dependent serotonin transporter63030Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464785P31645Espacenet
JP 2026004568 A2026-01-1464787P31645Espacenet
EP 4641201 A22025-10-291523P31645Espacenet
JP 2025529142 A2025-09-044289P31645Espacenet
US 12371689 B22025-07-294289P31645Espacenet
JP 2025517969 A2025-06-121523P31645Espacenet
US 12221654 B22025-02-112P31645Espacenet
JP 2023519296 A2023-05-1068P31645Espacenet
US 11446398 B22022-09-2082051P31645Espacenet
US 11446398 B22022-09-2082053P31645Espacenet

Drugs 68

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMITIFADINECHEMBL592374Monoamine transporter inhibitorINHIBITORChEMBL
AMITRIPTYLINECHEMBL629Serotonin transporter inhibitorINHIBITORChEMBL
AMITRIPTYLINE HYDROCHLORIDECHEMBL1200964Serotonin transporter inhibitorINHIBITORChEMBL
AMOXAPINECHEMBL1113Serotonin transporter inhibitorINHIBITORChEMBL
BICIFADINECHEMBL511099Monoamine transporter inhibitorINHIBITORChEMBL
CENTANAFADINECHEMBL3301621Monoamine transporter inhibitorINHIBITORChEMBL
CHLORPHENTERMINECHEMBL1201269Serotonin transporter substrateSUBSTRATEChEMBL
CHLORPHENTERMINE HYDROCHLORIDECHEMBL1200595Serotonin transporter substrateSUBSTRATEChEMBL
CITALOPRAMCHEMBL549Serotonin transporter inhibitorINHIBITORChEMBL
CITALOPRAM HYDROBROMIDECHEMBL1200781Serotonin transporter inhibitorINHIBITORChEMBL

Trials 1665

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07590609ESCITALOPRAMPHASE4ClinicalTrials.gov
NCT07588750SIBUTRAMINEClinicalTrials.gov
NCT07574060SERTRALINEPHASE2/PHASE3ClinicalTrials.gov
NCT07569159MIDOMAFETAMINEPHASE2ClinicalTrials.gov
NCT07556718AMITRIPTYLINEPHASE2ClinicalTrials.gov
NCT07542145MIDOMAFETAMINEPHASE1ClinicalTrials.gov
NCT07539805SERTRALINEPHASE2ClinicalTrials.gov
NCT07533487DULOXETINEClinicalTrials.gov
NCT07533487MILNACIPRANClinicalTrials.gov
NCT07527481NORTRIPTYLINEClinicalTrials.gov

NIH grants 8060

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAAA000301Integrative genetics of behavior with high throughput technologies732,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files
ZIADA000389Novel Probes for the Monoamine Transporters242,025NIH's project files
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).202,025NIH's project files
ZIADA000522Preclinical medication development for stimulant use disorder202,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism192,025NIH's project files
T32MH020030ResearchTraining: Psychiatric and Statistical Genetics192,025NIH's project files
P51OD011107California National Primate Research Center182,025NIH's project files
ZIADA000523Pharmacology and toxicology of new psychoactive substances162,025NIH's project files
ZIAMH002793PET Radiopharmaceutical Sciences152,025NIH's project files

Papers 17444

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822726PubTator, text miningPubMed
42809593PubTator, text miningPubMed
42802518PubTator, text miningPubMed
42800567PubTator, text miningPubMed
42783207PubTator, text miningPubMed
42770193PubTator, text miningPubMed
42755715PubTator, text miningPubMed
42727738PubTator, text miningPubMed
42727736PubTator, text miningPubMed
42716315PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license