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Gene · 6536

SLC6A9: solute carrier family 6 member 9

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC6A9: solute carrier family 6 member 9. Genes, record 6536. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6536

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Gene

Symbol
SLC6A9
HGNC
Name
solute carrier family 6 member 9
HGNC
NCBI Gene ID
6536
NCBI Gene
HGNC ID
HGNC:11056
HGNC
Ensembl
ENSG00000196517
NCBI Gene
Aliases
GCENSG, GLYT1, GlyT-1, IS6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48067Sodium- and chloride-dependent glycine transporter 17069Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21332P48067Espacenet
JP 2026004568 A2026-01-1464774P48067Espacenet
EP 4641202 A22025-10-29427P48067Espacenet
JP 2025147176 A2025-10-0612430P48067Espacenet
JP 2025529142 A2025-09-044294P48067Espacenet
JP 2025529142 A2025-09-047741P48067Espacenet
US 12371689 B22025-07-294294P48067Espacenet
US 12371689 B22025-07-297741P48067Espacenet
JP 2025028160 A2025-02-2812430P48067Espacenet
KR 1020250017231 A2025-02-04427P48067Espacenet

1 to 10 of 24

See all 24 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BITOPERTINCHEMBL1171829Glycine transporter 1 inhibitorINHIBITORChEMBL
ORG-25935CHEMBL4228124Glycine transporter 1 inhibitorINHIBITORChEMBL
PF-03463275CHEMBL563251Glycine transporter 1 inhibitorINHIBITORChEMBL

Trials23

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603401BITOPERTINClinicalTrials.gov
NCT07123363BITOPERTINPHASE1ClinicalTrials.gov
NCT06910358BITOPERTINPHASE3ClinicalTrials.gov
NCT05883748BITOPERTINPHASE2/PHASE3ClinicalTrials.gov
NCT05828108BITOPERTINPHASE1/PHASE2ClinicalTrials.gov
NCT05308472BITOPERTINPHASE22026-01-08ClinicalTrials.gov
NCT03271541BITOPERTINPHASE2ClinicalTrials.gov
NCT01911676PF-03463275PHASE22023-02-27ClinicalTrials.gov
NCT01674361BITOPERTINPHASE2ClinicalTrials.gov
NCT01235585BITOPERTINPHASE3ClinicalTrials.gov

1 to 10 of 23

See all 23 trials

NIH grants651

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC6A9 papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award72025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
P30CA068485Cancer Center Support Grant32025
P30DK058404Molecular and Cellular Basis for Digestive Diseases32025
P30EY008126Core Grant in Vision Research32025
P50AA012870Center for the Translational Neuroscience of Alcoholism32025
R01MH062646Regulation of Signaling by mGluR532025
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes32025
P30CA016058Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025

1 to 10 of 651Source NIH's project files

See all 651 nih grants

Papers985

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi criteria evaluation of schizophrenia drugs: DFT, ADMET, and molecular docking investigations.Comput Biol Chem202642800397PubTator, text miningPubMed
Novel SLC6A9 variants in an adult presenting with GlyT1 encephalopathy.J Hum Genet202642728308PubTator, text miningPubMed
Targeting glycine transporter type 1 (GlyT1) in epilepsy: Pathophysiological rationale and therapeutic perspectives.Pharmacol Ther202642668023PubTator, text miningPubMed
Results from the first clinical trial of bitopertin for steroid-relapsed/refractory Diamond-Blackfan anemia.Blood Red Cells Iron202642583025PubTator, text miningPubMed
Emerging non-D2 receptor-based therapies for schizophrenia: a focus on muscarinic and glutamatergic pathways.Front Psychiatry202642500322PubTator, text miningPubMed
Pharmacokinetic/pharmacodynamic analysis to characterize the effect of long-term GlyT1 inhibitor iclepertin exposure on hemoglobin levels.Front Pharmacol202642499503PubTator, text miningPubMed
Clinicopathological and molecular characterization of HPV-associated cervical poorly cohesive carcinoma: a rare aggressive entity.J Pathol Clin Res202642289532PubTator, text miningPubMed
Accelerated Sampling of Protein Dynamics Using BioEmu-Augmented Molecular Simulation.J Chem Inf Model202642268730PubTator, text miningPubMed
Dendrobine inhibits the growth and invasion of human breast cancer cells by regulating the NF-κB signaling pathway via the SLC6A9 target.Cytotechnology202642153166PubTator, text miningPubMed
The Effect of Iclepertin on Hematological Parameters: An Overview of Nonclinical Studies and Clinical Trials in Healthy Volunteers and Patients with Cognitive Impairment Associated with Schizophrenia.J Clin Pharmacol202642053463PubTator, text miningPubMed

1 to 10 of 985

See all 985 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6536

GET https://conductscience.org/api/genes/v1/6536/patents?page=2