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Gene · 6548

SLC9A1: solute carrier family 9 member A1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC9A1: solute carrier family 9 member A1. Genes, record 6548. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6548

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Gene

Symbol
SLC9A1
HGNC
Name
solute carrier family 9 member A1
HGNC
NCBI Gene ID
6548
NCBI Gene
HGNC ID
HGNC:11071
HGNC
Ensembl
ENSG00000090020
NCBI Gene
Aliases
APNH, LIKNS, NHE-1, NHE1, PPP1R143
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P19634Sodium/hydrogen exchanger 181520Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464861P19634Espacenet
EP 4650780 A22025-11-192280P19634Espacenet
JP 2025529142 A2025-09-044312P19634Espacenet
US 12371689 B22025-07-294312P19634Espacenet
JP 2025517970 A2025-06-122280P19634Espacenet
JP 2023086836 A2023-06-2297P19634Espacenet
JP 2023505833 A2023-02-1397P19634Espacenet
US 11446398 B22022-09-2082213P19634Espacenet
US 11400116 B22022-08-027322P19634Espacenet
JP 2022524081 A2022-04-27185184P19634Espacenet

1 to 10 of 34

See all 34 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,862

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC9A1 papersNewest fiscal year
R01NS048216Na/H Exchanger in Microglial Metabolism and Function252025
P30CA076292Moffitt Cancer Center Support Grant72025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)72025
R01DK067528Mechanisms of Tubular Atrophy72025
R01CA197855Roles for Intracellular pH Dynamics in Cancer62025
P30CA016672Cancer Center Support Grant52025
P30DK034854Integrated Epithelial and Muscosal Biology52025
P50CA211015UCLA SPORE in Brain Cancer42025
P30CA008748Cancer Center Support Grant32025
P30CA010815Consolidated Basic Cancer Research Program32025

1 to 10 of 1,862Source NIH's project files

See all 1,862 nih grants

Papers3,457

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inhibition of NHE1 Overcomes Temozolomide-Resistance in Glioblastoma via ROS-AKT/ERK Axis-Mediated Autophagy Suppression.J Biochem Mol Toxicol202642740476PubTator, text miningPubMed
Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair.Adv Sci (Weinh)202642723198PubTator, text miningPubMed
Cardiomyocyte calcium homeostasis remodeling in diabetes-related HFpEF: mechanisms and therapeutic perspectives.Pharmacol Res202642697419PubTator, text miningPubMed
Revising NHE-1: From Cardiac Homeostasis to Heart Failure and Future Drug Development.Cell Biochem Funct202642677384PubTator, text miningPubMed
NHE1 in Gastrointestinal Inflammation and Cancer: A Double-Edged Regulator.Dig Dis Sci202642635895PubTator, text miningPubMed
Genetically predicted triglyceride levels and endometriosis risk: Mendelian randomization with exploratory multi-omics analyses.PLoS One202642594068PubTator, text miningPubMed
CD44-targeting small-molecule inhibitors restore hyaluronan homeostasis and reduce profibrotic matrix remodeling in vocal fold fibroblasts exposed to cigarette smoke extract.Toxicology202642562202PubTator, text miningPubMed
Recent progress in small molecules targeting the acidic tumor microenvironment.J Enzyme Inhib Med Chem202642550763PubTator, text miningPubMed
Biomarker-guided pharmacotherapy in cardiovascular-kidney-metabolic syndrome: A three-dimensional framework for precision drug selection and monitoring.Pharmacol Ther202642492739PubTator, text miningPubMed
DLK1-35 Contributes to Temozolomide Resistance in Glioblastoma Through the miR-140-3p/NHE1/ERK-MGMT Axis.Tohoku J Exp Med202642486642PubTator, text miningPubMed

1 to 10 of 3,457

See all 3,457 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6548

GET https://conductscience.org/api/genes/v1/6548/patents?page=2