Gene · 6550
SLC9A3: solute carrier family 9 member A3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC9A3: solute carrier family 9 member A3. Genes, record 6550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6550
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48764 | Sodium/hydrogen exchanger 3 | 834 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64868 | P48764 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1995 | P48764 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4314 | P48764 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4314 | P48764 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1995 | P48764 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 36112 | P48764 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 36112 | P48764 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 36112 | P48764 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 82217 | P48764 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 2980 | P48764 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| SQUALAMINE | CHEMBL444929 | Sodium/hydrogen exchanger 3 inhibitor | INHIBITOR | ChEMBL |
| SQUALAMINE LACTATE | CHEMBL3989689 | Sodium/hydrogen exchanger 3 inhibitor | INHIBITOR | ChEMBL |
| TENAPANOR | CHEMBL3304485 | Sodium/hydrogen exchanger 3 inhibitor | INHIBITOR | ChEMBL |
| TENAPANOR HYDROCHLORIDE | CHEMBL3301627 | Sodium/hydrogen exchanger 3 inhibitor | INHIBITOR | ChEMBL |
Trials29
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06460038 | TENAPANOR | PHASE2 | ClinicalTrials.gov | |
| NCT04780841 | TENAPANOR | PHASE2 | ClinicalTrials.gov | |
| NCT04771780 | TENAPANOR | PHASE3 | ClinicalTrials.gov | |
| NCT04767581 | TENAPANOR | PHASE3 | ClinicalTrials.gov | |
| NCT04766398 | TENAPANOR | PHASE3 | ClinicalTrials.gov | |
| NCT04766385 | TENAPANOR | PHASE3 | ClinicalTrials.gov | |
| NCT03864458 | TENAPANOR | PHASE2 | ClinicalTrials.gov | |
| NCT03864445 | TENAPANOR | PHASE2 | ClinicalTrials.gov | |
| NCT03831607 | TENAPANOR | PHASE2 | ClinicalTrials.gov | |
| NCT03824587 | TENAPANOR | PHASE2/PHASE3 | 2023-03-06 | ClinicalTrials.gov |
1 to 10 of 29
See all 29 trialsNIH grants1,442
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC9A3 papers | Newest fiscal year |
|---|---|---|---|
| P30DK042086 | Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) | 27 | 2025 |
| R01DK067299 | Novel Roles and Mechanisms of Proximal Tubule Mitochondrial Angiotensin II and Sirtuin 3 in Hypertension | 26 | 2025 |
| R01DK061931 | Mechanisms and pathophysiologic impact of claudin-2 modulation | 14 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 13 | 2025 |
| R01DK083785 | Renal electrolyte handling in females vs. males over life cycle | 11 | 2025 |
| R01DK048370 | Small GTP Binding Proteins in Gastrointestinal Mucosa | 10 | 2025 |
| R01DK068271 | Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease. | 10 | 2025 |
| R01DK112042 | Glomerular and Tubular Function in the Diabetic Kidney | 10 | 2025 |
| RC2DK118640 | COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository | 10 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 9 | 2025 |
1 to 10 of 1,442Source NIH's project files
See all 1,442 nih grantsPapers2,789
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A Novel Epigenetic Mechanism of Intestinal NHE3 Gene Regulation by Histone Acetylation. | Int J Mol Sci | 2026 | 42794528 | PubTator, text mining | PubMed |
| Dapagliflozin Beyond Glucose Lowering: Mechanisms of Renal and Systemic Protection. | Pathophysiology | 2026 | 42784236 | PubTator, text mining | PubMed |
| Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments. | Recent Adv Inflamm Allergy Drug Discov | 2026 | 42770362 | PubTator, text mining | PubMed |
| A biochemical difference between HAI-2 variants causing syndromic and non-syndromic Congenital Sodium Diarrhea. | PLoS One | 2026 | 42743157 | PubTator, text mining | PubMed |
| Exploratory Genome and Transcriptome-Wide Association Analyses of Addiction-Related Phenotypes in a Twin Cohort. | Biomedicines | 2026 | 42652060 | PubTator, text mining | PubMed |
Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JMKX003002 in Chinese healthy participants: a randomized, double-blind, placebo-controlled, single- and multiple-ascending dose, and food-effect phase I clinical trial. | Ann Med | 2026 | 42472689 | PubTator, text mining | PubMed |
| Aldosterone suppresses Na+/H+ exchanger-3 expression through miR-204-5P-mediated posttranscriptional regulation in distal colon. | Am J Physiol Gastrointest Liver Physiol | 2026 | 42467551 | PubTator, text mining | PubMed |
| Genomic landscape of rare variants in a Chinese autism cohort and discovery of novel risk genes. | Mol Psychiatry | 2026 | 42463903 | PubTator, text mining | PubMed |
The Compound Terminalia Chebula Extract Alleviates PEDV-Induced Colonic Injury in Suckling Piglets by Enhancing Antioxidant Capacity, Suppressing Inflammation, Restoring Intestinal Function, and Inhibiting Viral Replication. | Animals (Basel) | 2026 | 42450791 | PubTator, text mining | PubMed |
| Clinical Changes after Tenapanor Initiation in Maintenance Hemodialysis Patients: A Two-Center Retrospective Observational Study. | Blood Purif | 2026 | 42418353 | PubTator, text mining | PubMed |
1 to 10 of 2,789
See all 2,789 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6550
GET https://conductscience.org/api/genes/v1/6550/patents?page=2