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Gene · 6550

SLC9A3: solute carrier family 9 member A3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC9A3: solute carrier family 9 member A3. Genes, record 6550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6550

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Gene

Symbol
SLC9A3
HGNC
Name
solute carrier family 9 member A3
HGNC
NCBI Gene ID
6550
NCBI Gene
HGNC ID
HGNC:11073
HGNC
Ensembl
ENSG00000066230
NCBI Gene
Aliases
DIAR8, NHE-3, NHE3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48764Sodium/hydrogen exchanger 38341Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464868P48764Espacenet
EP 4641201 A22025-10-291995P48764Espacenet
JP 2025529142 A2025-09-044314P48764Espacenet
US 12371689 B22025-07-294314P48764Espacenet
JP 2025517969 A2025-06-121995P48764Espacenet
JP 2025032204 A2025-03-1136112P48764Espacenet
EP 4461818 A22024-11-1336112P48764Espacenet
JP 2023058610 A2023-04-2536112P48764Espacenet
US 11446398 B22022-09-2082217P48764Espacenet
US 11400116 B22022-08-022980P48764Espacenet

1 to 10 of 21

See all 21 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
SQUALAMINECHEMBL444929Sodium/hydrogen exchanger 3 inhibitorINHIBITORChEMBL
SQUALAMINE LACTATECHEMBL3989689Sodium/hydrogen exchanger 3 inhibitorINHIBITORChEMBL
TENAPANORCHEMBL3304485Sodium/hydrogen exchanger 3 inhibitorINHIBITORChEMBL
TENAPANOR HYDROCHLORIDECHEMBL3301627Sodium/hydrogen exchanger 3 inhibitorINHIBITORChEMBL

Trials29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06460038TENAPANORPHASE2ClinicalTrials.gov
NCT04780841TENAPANORPHASE2ClinicalTrials.gov
NCT04771780TENAPANORPHASE3ClinicalTrials.gov
NCT04767581TENAPANORPHASE3ClinicalTrials.gov
NCT04766398TENAPANORPHASE3ClinicalTrials.gov
NCT04766385TENAPANORPHASE3ClinicalTrials.gov
NCT03864458TENAPANORPHASE2ClinicalTrials.gov
NCT03864445TENAPANORPHASE2ClinicalTrials.gov
NCT03831607TENAPANORPHASE2ClinicalTrials.gov
NCT03824587TENAPANORPHASE2/PHASE32023-03-06ClinicalTrials.gov

1 to 10 of 29

See all 29 trials

NIH grants1,442

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC9A3 papersNewest fiscal year
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)272025
R01DK067299Novel Roles and Mechanisms of Proximal Tubule Mitochondrial Angiotensin II and Sirtuin 3 in Hypertension262025
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation142025
P30DK034854Integrated Epithelial and Muscosal Biology132025
R01DK083785Renal electrolyte handling in females vs. males over life cycle112025
R01DK048370Small GTP Binding Proteins in Gastrointestinal Mucosa102025
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.102025
R01DK112042Glomerular and Tubular Function in the Diabetic Kidney102025
RC2DK118640COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository102025
P30DK058404Molecular and Cellular Basis for Digestive Diseases92025

1 to 10 of 1,442Source NIH's project files

See all 1,442 nih grants

Papers2,789

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Novel Epigenetic Mechanism of Intestinal NHE3 Gene Regulation by Histone Acetylation.Int J Mol Sci202642794528PubTator, text miningPubMed
Dapagliflozin Beyond Glucose Lowering: Mechanisms of Renal and Systemic Protection.Pathophysiology202642784236PubTator, text miningPubMed
Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments.Recent Adv Inflamm Allergy Drug Discov202642770362PubTator, text miningPubMed
A biochemical difference between HAI-2 variants causing syndromic and non-syndromic Congenital Sodium Diarrhea.PLoS One202642743157PubTator, text miningPubMed
Exploratory Genome and Transcriptome-Wide Association Analyses of Addiction-Related Phenotypes in a Twin Cohort.Biomedicines202642652060PubTator, text miningPubMed
Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JMKX003002 in Chinese healthy participants: a randomized, double-blind, placebo-controlled, single- and multiple-ascending dose, and food-effect phase I clinical trial.
Ann Med202642472689PubTator, text miningPubMed
Aldosterone suppresses Na+/H+ exchanger-3 expression through miR-204-5P-mediated posttranscriptional regulation in distal colon.Am J Physiol Gastrointest Liver Physiol202642467551PubTator, text miningPubMed
Genomic landscape of rare variants in a Chinese autism cohort and discovery of novel risk genes.Mol Psychiatry202642463903PubTator, text miningPubMed
The Compound Terminalia Chebula Extract Alleviates PEDV-Induced Colonic Injury in Suckling Piglets by Enhancing Antioxidant Capacity, Suppressing Inflammation, Restoring Intestinal Function, and Inhibiting Viral Replication.
Animals (Basel)202642450791PubTator, text miningPubMed
Clinical Changes after Tenapanor Initiation in Maintenance Hemodialysis Patients: A Two-Center Retrospective Observational Study.Blood Purif202642418353PubTator, text miningPubMed

1 to 10 of 2,789

See all 2,789 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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