Gene · 6554
SLC10A1: solute carrier family 10 member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC10A1: solute carrier family 10 member 1. Genes, record 6554. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6554
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14973 | Hepatic sodium/bile acid cotransporter | 349 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63956 | Q14973 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 357 | Q14973 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3979 | Q14973 | Espacenet |
| JP 2025524620 A | 2025-07-30 | 399 | Q14973 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3979 | Q14973 | Espacenet |
| WO 2025151800 A1 | 2025-07-17 | 399 | Q14973 | Espacenet |
| WO 2025151803 A1 | 2025-07-17 | 399 | Q14973 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 357 | Q14973 | Espacenet |
| EP 4556017 A1 | 2025-05-21 | 7 | Q14973 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80311 | Q14973 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BULEVIRTIDE | CHEMBL4297711 | Bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| BULEVIRTIDE ACETATE | CHEMBL5315080 | Bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| HEPALATIDE | CHEMBL4650398 | Bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| MYRCLUDEX B | CHEMBL4297792 | Bile acid transporter inhibitor | INHIBITOR | ChEMBL |
Trials20
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07309380 | HEPALATIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06505928 | HEPALATIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06504485 | BULEVIRTIDE | ClinicalTrials.gov | ||
| NCT06397859 | BULEVIRTIDE | ClinicalTrials.gov | ||
| NCT06122285 | BULEVIRTIDE | ClinicalTrials.gov | ||
| NCT06051045 | BULEVIRTIDE | ClinicalTrials.gov | ||
| NCT05962307 | BULEVIRTIDE | ClinicalTrials.gov | ||
| NCT05928000 | BULEVIRTIDE | ClinicalTrials.gov | ||
| NCT05827146 | HEPALATIDE | PHASE2 | ClinicalTrials.gov | |
| NCT05718700 | BULEVIRTIDE | ClinicalTrials.gov |
1 to 10 of 20
See all 20 trialsNIH grants1,213
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC10A1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK034989 | Yale Liver Center | 16 | 2025 |
| R01AI110762 | Molecular Mechanisms of HBV cccDNA Formation | 16 | 2025 |
| R35GM122576 | Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy | 13 | 2025 |
| R01AI107301 | Genetic Viral and Host Adaptations to Breach Species Barriers of HCV | 11 | 2025 |
| R01AI134818 | The Role of HBeAg in HBV Persistence | 10 | 2025 |
| ZIADK054500 | Molecular Mechanisms Of Hepatitis B Viral infection, Pathogenesis And Persistence | 9 | 2025 |
| R37AI043453 | Mechanisms of Hepadnavirus Assembly and Replication | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 6 | 2025 |
| P30DK120531 | Pittsburgh Liver Research Center | 6 | 2025 |
1 to 10 of 1,213Source NIH's project files
See all 1,213 nih grantsPapers3,134
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling. | J Ethnopharmacol | 2027 | 42503322 | PubTator, text mining | PubMed |
| Reciprocal cross-species infection potential of human and domestic cat hepatitis B viruses. | Hepatology | 2026 | 42821865 | PubTator, text mining | PubMed |
| Intracellular Zn2+ levels regulate susceptibility to hepatitis B virus infection by modulating NTCP-mediated viral entry. | Antiviral Res | 2026 | 42810521 | PubTator, text mining | PubMed |
| Vectors Trgeting Hepatocyte: Reconstructive Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes. | Tissue Eng Regen Med | 2026 | 42726456 | PubTator, text mining | PubMed |
| Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. | Clin Pharmacol Ther | 2026 | 42698006 | PubTator, text mining | PubMed |
Cortisol drives pregnancy-associated induction of hepatic organic anion transporter 2, sodium/taurocholate cotransporting polypeptide, and organic cation transporter 1 in HepaRG cells through glucocorticoid receptor-, hepatocyte nuclear factor 1 alpha-, and hepatocyte nuclear factor 4 alpha-dependent signaling. | Drug Metab Dispos | 2026 | 42685389 | PubTator, text mining | PubMed |
| Notoginsenoside R1 alleviates cholestatic liver fibrosis through modulation of the intestinal FXR-FGF15 axis and bile acid homeostasis. | Biochem Pharmacol | 2026 | 42556477 | PubTator, text mining | PubMed |
| Structural insight into sodium-dependent bile acid transport by members of the SLC10 family. | Structure | 2026 | 42546690 | PubTator, text mining | PubMed |
| Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B. | J Clin Transl Hepatol | 2026 | 42483736 | PubTator, text mining | PubMed |
| Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling. | bioRxiv | 2026 | 42367899 | PubTator, text mining | PubMed |
1 to 10 of 3,134
See all 3,134 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6554
GET https://conductscience.org/api/genes/v1/6554/patents?page=2