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Gene · 6554

SLC10A1: solute carrier family 10 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC10A1: solute carrier family 10 member 1. Genes, record 6554. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6554

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Gene

Symbol
SLC10A1
HGNC
Name
solute carrier family 10 member 1
HGNC
NCBI Gene ID
6554
NCBI Gene
HGNC ID
HGNC:10905
HGNC
Ensembl
ENSG00000100652
NCBI Gene
Aliases
FHCA2, NTCP, NTCP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14973Hepatic sodium/bile acid cotransporter34911Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463956Q14973Espacenet
EP 4650780 A22025-11-19357Q14973Espacenet
JP 2025529142 A2025-09-043979Q14973Espacenet
JP 2025524620 A2025-07-30399Q14973Espacenet
US 12371689 B22025-07-293979Q14973Espacenet
WO 2025151800 A12025-07-17399Q14973Espacenet
WO 2025151803 A12025-07-17399Q14973Espacenet
JP 2025517970 A2025-06-12357Q14973Espacenet
EP 4556017 A12025-05-217Q14973Espacenet
US 11446398 B22022-09-2080311Q14973Espacenet

1 to 10 of 38

See all 38 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BULEVIRTIDECHEMBL4297711Bile acid transporter inhibitorINHIBITORChEMBL
BULEVIRTIDE ACETATECHEMBL5315080Bile acid transporter inhibitorINHIBITORChEMBL
HEPALATIDECHEMBL4650398Bile acid transporter inhibitorINHIBITORChEMBL
MYRCLUDEX BCHEMBL4297792Bile acid transporter inhibitorINHIBITORChEMBL

Trials20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,213

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC10A1 papersNewest fiscal year
P30DK034989Yale Liver Center162025
R01AI110762Molecular Mechanisms of HBV cccDNA Formation162025
R35GM122576Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy132025
R01AI107301Genetic Viral and Host Adaptations to Breach Species Barriers of HCV112025
R01AI134818The Role of HBeAg in HBV Persistence102025
ZIADK054500Molecular Mechanisms Of Hepatitis B Viral infection, Pathogenesis And Persistence92025
R37AI043453Mechanisms of Hepadnavirus Assembly and Replication82025
UL1TR001863Yale Clinical and Translational Science Award72025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology62025
P30DK120531Pittsburgh Liver Research Center62025

1 to 10 of 1,213Source NIH's project files

See all 1,213 nih grants

Papers3,134

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling.J Ethnopharmacol202742503322PubTator, text miningPubMed
Reciprocal cross-species infection potential of human and domestic cat hepatitis B viruses.Hepatology202642821865PubTator, text miningPubMed
Intracellular Zn2+ levels regulate susceptibility to hepatitis B virus infection by modulating NTCP-mediated viral entry.Antiviral Res202642810521PubTator, text miningPubMed
Vectors Trgeting Hepatocyte: Reconstructive Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes.Tissue Eng Regen Med202642726456PubTator, text miningPubMed
Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray.Clin Pharmacol Ther202642698006PubTator, text miningPubMed
Cortisol drives pregnancy-associated induction of hepatic organic anion transporter 2, sodium/taurocholate cotransporting polypeptide, and organic cation transporter 1 in HepaRG cells through glucocorticoid receptor-, hepatocyte nuclear factor 1 alpha-, and hepatocyte nuclear factor 4 alpha-dependent signaling.
Drug Metab Dispos202642685389PubTator, text miningPubMed
Notoginsenoside R1 alleviates cholestatic liver fibrosis through modulation of the intestinal FXR-FGF15 axis and bile acid homeostasis.Biochem Pharmacol202642556477PubTator, text miningPubMed
Structural insight into sodium-dependent bile acid transport by members of the SLC10 family.Structure202642546690PubTator, text miningPubMed
Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B.J Clin Transl Hepatol202642483736PubTator, text miningPubMed
Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling.bioRxiv202642367899PubTator, text miningPubMed

1 to 10 of 3,134

See all 3,134 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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