Gene · 6555
SLC10A2: solute carrier family 10 member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC10A2: solute carrier family 10 member 2. Genes, record 6555. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6555
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q12908 | Ileal sodium/bile acid cotransporter | 348 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents12
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63957 | Q12908 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 128 | Q12908 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 814 | Q12908 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3980 | Q12908 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3980 | Q12908 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 128 | Q12908 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 814 | Q12908 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80312 | Q12908 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183283 | Q12908 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 244392 | Q12908 | Espacenet |
1 to 10 of 12
See all 12 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ELOBIXIBAT | CHEMBL3039515 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| LINERIXIBAT | CHEMBL2387408 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| MARALIXIBAT | CHEMBL363392 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| MARALIXIBAT CHLORIDE | CHEMBL17879 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| ODEVIXIBAT | CHEMBL4297588 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| ODEVIXIBAT SESQUIHYDRATE | CHEMBL5315120 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
| VOLIXIBAT | CHEMBL3707222 | Ileal bile acid transporter inhibitor | INHIBITOR | ChEMBL |
Trials51
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07389031 | MARALIXIBAT | PHASE2 | ClinicalTrials.gov | |
| NCT07293897 | MARALIXIBAT | ClinicalTrials.gov | ||
| NCT07290257 | MARALIXIBAT CHLORIDE | PHASE4 | ClinicalTrials.gov | |
| NCT06436833 | ELOBIXIBAT | ClinicalTrials.gov | ||
| NCT06413368 | MARALIXIBAT | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06193928 | MARALIXIBAT | ClinicalTrials.gov | ||
| NCT05543187 | MARALIXIBAT | PHASE3 | 2024-09-24 | ClinicalTrials.gov |
| NCT05543174 | MARALIXIBAT | PHASE3 | 2024-10-15 | ClinicalTrials.gov |
| NCT05448170 | LINERIXIBAT | ClinicalTrials.gov | ||
| NCT05426733 | ODEVIXIBAT | PHASE3 | ClinicalTrials.gov |
1 to 10 of 51
See all 51 trialsNIH grants958
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC10A2 papers | Newest fiscal year |
|---|---|---|---|
| U01FD005946 | University of Maryland Center of Excellence in Regulatory Science and Innovation | 14 | 2025 |
| P30DK034989 | Yale Liver Center | 13 | 2025 |
| R01DK117965 | Regulation of Bile Acid Metabolism and Signaling in Metabolic Diseases | 7 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 6 | 2025 |
| P30DK084567 | Mayo Center for Cell Signaling in Gastroenterology | 5 | 2025 |
| P30DK120531 | Pittsburgh Liver Research Center | 5 | 2025 |
| R35GM122576 | Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy | 5 | 2025 |
| I01BX000152 | Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders | 4 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 4 | 2025 |
1 to 10 of 958Source NIH's project files
See all 958 nih grantsPapers1,442
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling. | J Ethnopharmacol | 2027 | 42503322 | PubTator, text mining | PubMed |
| Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults. | Drug Metab Dispos | 2026 | 42826635 | PubTator, text mining | PubMed |
| Correlated electron behavior and low-temperature magnetic anomalies in CeCo2Al8. | J Phys Condens Matter | 2026 | 42551485 | PubTator, text mining | PubMed |
| Structural insight into sodium-dependent bile acid transport by members of the SLC10 family. | Structure | 2026 | 42546690 | PubTator, text mining | PubMed |
| Parvovirus B19 infection as a trigger of acute cholestasis in heterozygous genetic BSEP deficiency: a case report and review of the literature of acute parvovirus B19-related hepatitis. | Intern Emerg Med | 2026 | 42496956 | PubTator, text mining | PubMed |
| Novel SLC10A2 variants induce primary bile acid malabsorption and dysbiosis with IBD-like features. | Inflamm Bowel Dis | 2026 | 42435330 | PubTator, text mining | PubMed |
| Targeted Ileal Bile Acid Transporter Inhibition as Rescue Therapy for Tirzepatide-Induced Severe Constipation: A Case Report. | Case Rep Gastroenterol | 2026 | 42421979 | PubTator, text mining | PubMed |
| Bile acids mediate liver-bone marrow crosstalk. | iScience | 2026 | 42389593 | PubTator, text mining | PubMed |
| Linerixibat: First Approval. | Drugs | 2026 | 42301363 | PubTator, text mining | PubMed |
| HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer. | J Clin Invest | 2026 | 42294886 | PubTator, text mining | PubMed |
1 to 10 of 1,442
See all 1,442 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6555
GET https://conductscience.org/api/genes/v1/6555/patents