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Gene · 6555

SLC10A2: solute carrier family 10 member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC10A2: solute carrier family 10 member 2. Genes, record 6555. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6555

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Gene

Symbol
SLC10A2
HGNC
Name
solute carrier family 10 member 2
HGNC
NCBI Gene ID
6555
NCBI Gene
HGNC ID
HGNC:10906
HGNC
Ensembl
ENSG00000125255
NCBI Gene
Aliases
ASBT, IBAT, ISBT, NTCP2, PBAM, PBAM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12908Ileal sodium/bile acid cotransporter3480Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463957Q12908Espacenet
EP 4640849 A22025-10-29128Q12908Espacenet
EP 4641201 A22025-10-29814Q12908Espacenet
JP 2025529142 A2025-09-043980Q12908Espacenet
US 12371689 B22025-07-293980Q12908Espacenet
JP 2025519096 A2025-06-24128Q12908Espacenet
JP 2025517969 A2025-06-12814Q12908Espacenet
US 11446398 B22022-09-2080312Q12908Espacenet
JP 2022524081 A2022-04-27183283Q12908Espacenet
JP 2019054813 A2019-04-11244392Q12908Espacenet

1 to 10 of 12

See all 12 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ELOBIXIBATCHEMBL3039515Ileal bile acid transporter inhibitorINHIBITORChEMBL
LINERIXIBATCHEMBL2387408Ileal bile acid transporter inhibitorINHIBITORChEMBL
MARALIXIBATCHEMBL363392Ileal bile acid transporter inhibitorINHIBITORChEMBL
MARALIXIBAT CHLORIDECHEMBL17879Ileal bile acid transporter inhibitorINHIBITORChEMBL
ODEVIXIBATCHEMBL4297588Ileal bile acid transporter inhibitorINHIBITORChEMBL
ODEVIXIBAT SESQUIHYDRATECHEMBL5315120Ileal bile acid transporter inhibitorINHIBITORChEMBL
VOLIXIBATCHEMBL3707222Ileal bile acid transporter inhibitorINHIBITORChEMBL

Trials51

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07389031MARALIXIBATPHASE2ClinicalTrials.gov
NCT07293897MARALIXIBATClinicalTrials.gov
NCT07290257MARALIXIBAT CHLORIDEPHASE4ClinicalTrials.gov
NCT06436833ELOBIXIBATClinicalTrials.gov
NCT06413368MARALIXIBATPHASE2/PHASE3ClinicalTrials.gov
NCT06193928MARALIXIBATClinicalTrials.gov
NCT05543187MARALIXIBATPHASE32024-09-24ClinicalTrials.gov
NCT05543174MARALIXIBATPHASE32024-10-15ClinicalTrials.gov
NCT05448170LINERIXIBATClinicalTrials.gov
NCT05426733ODEVIXIBATPHASE3ClinicalTrials.gov

1 to 10 of 51

See all 51 trials

NIH grants958

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC10A2 papersNewest fiscal year
U01FD005946University of Maryland Center of Excellence in Regulatory Science and Innovation142025
P30DK034989Yale Liver Center132025
R01DK117965Regulation of Bile Acid Metabolism and Signaling in Metabolic Diseases72025
UL1TR001863Yale Clinical and Translational Science Award72025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology52025
P30DK120531Pittsburgh Liver Research Center52025
R35GM122576Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy52025
I01BX000152Regulation of Intestinal Bile Acid Absorption in Health and Cholesterol-Related Disorders42025
P30DK034854Integrated Epithelial and Muscosal Biology42025

1 to 10 of 958Source NIH's project files

See all 958 nih grants

Papers1,442

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mulberry leaf flavonoids alleviate type 2 diabetes by remodeling the gut microbiota-bile acid axis and activating FXR signaling.J Ethnopharmacol202742503322PubTator, text miningPubMed
Proteomic profiling of drug and nutrient transporter expression by small intestinal region in neonates, pediatrics, and adults.Drug Metab Dispos202642826635PubTator, text miningPubMed
Correlated electron behavior and low-temperature magnetic anomalies in CeCo2Al8.J Phys Condens Matter202642551485PubTator, text miningPubMed
Structural insight into sodium-dependent bile acid transport by members of the SLC10 family.Structure202642546690PubTator, text miningPubMed
Parvovirus B19 infection as a trigger of acute cholestasis in heterozygous genetic BSEP deficiency: a case report and review of the literature of acute parvovirus B19-related hepatitis.Intern Emerg Med202642496956PubTator, text miningPubMed
Novel SLC10A2 variants induce primary bile acid malabsorption and dysbiosis with IBD-like features.Inflamm Bowel Dis202642435330PubTator, text miningPubMed
Targeted Ileal Bile Acid Transporter Inhibition as Rescue Therapy for Tirzepatide-Induced Severe Constipation: A Case Report.Case Rep Gastroenterol202642421979PubTator, text miningPubMed
Bile acids mediate liver-bone marrow crosstalk.iScience202642389593PubTator, text miningPubMed
Linerixibat: First Approval.Drugs202642301363PubTator, text miningPubMed
HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer.J Clin Invest202642294886PubTator, text miningPubMed

1 to 10 of 1,442

See all 1,442 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6555

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