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Gene · 6556

SLC11A1: solute carrier family 11 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC11A1: solute carrier family 11 member 1. Genes, record 6556. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6556

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Gene

Symbol
SLC11A1
HGNC
Name
solute carrier family 11 member 1
HGNC
NCBI Gene ID
6556
NCBI Gene
HGNC ID
HGNC:10907
HGNC
Ensembl
ENSG00000018280
NCBI Gene
Aliases
LSH, NRAMP, NRAMP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49279Natural resistance-associated macrophage protein 15502Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463965P49279Espacenet
EP 4641201 A22025-10-29595P49279Espacenet
JP 2025529142 A2025-09-043986P49279Espacenet
US 12371689 B22025-07-293986P49279Espacenet
JP 2025517969 A2025-06-12595P49279Espacenet
US 12006548 B22024-06-11464P49279Espacenet
US 11446398 B22022-09-2080327P49279Espacenet
US 11400116 B22022-08-02166P49279Espacenet
JP 2022524081 A2022-04-27183298P49279Espacenet
US 11078247 B22021-08-0310331P49279Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants955

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC11A1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202842025
R01AI073843Pathobiology of heme inducible transporters in Gram positive pathogens42025
R01AI101171Host-mediated zinc sequestration during Acinetobacter baumannii infection42025
R01AI116059Mechanisms of persistent Salmonella infection42025
P30CA068485Cancer Center Support Grant32025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)32025
R01AI055472Host Cell Signaling Pathways Induced by Salmonella32025
R01ES010563Mechanisms of Manganese Neurotoxicity32025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes32025

1 to 10 of 955Source NIH's project files

See all 955 nih grants

Papers2,059

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multilevel Mechanisms by Which Membrane Transport Proteins Regulate Plant Responses to Heavy Metal Stress: From Ion Perception and Uptake Control to Systemic Signaling and Translational Perspectives.Plant Cell Environ202642782210PubTator, text miningPubMed
Genetic Variants of NRAMP1 and Hepcidin (HAMP) in Cancer Patients Infected with Human Herpesvirus-6.Viral Immunol202642752297PubTator, text miningPubMed
Melatonin as a hub signal integrating redox and hormonal crosstalk with multi-omics regulation in plant heavy metal stress tolerance.Plant Physiol Biochem202642731282PubTator, text miningPubMed
LsNAC72 from a major QTL activates LsNRAMP7 expression to promote iron accumulation in lettuce.Plant Physiol202642635652PubTator, text miningPubMed
Decoding macrophage-driven tumor heterogeneity in renal cell carcinoma using spatial and single-cell transcriptomics.Transl Oncol202642580154PubTator, text miningPubMed
Evaluation of the SLC11A1 non-synonymous variant rs17235409 and tuberculosis susceptibility in a multi-ethnic population from southwestern China.Medicine (Baltimore)202642470058PubTator, text miningPubMed
Harnessing biostimulants to alleviate potentially toxic element stress in vegetable crops.Planta202642463972PubTator, text miningPubMed
CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization.Adv Sci (Weinh)202642439546PubTator, text miningPubMed
Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant Cell Rep202642329452PubTator, text miningPubMed
An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters.J Biol Chem202642264089PubTator, text miningPubMed

1 to 10 of 2,059

See all 2,059 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6556

GET https://conductscience.org/api/genes/v1/6556/patents?page=2