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Gene · 6557

SLC12A1: solute carrier family 12 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC12A1: solute carrier family 12 member 1. Genes, record 6557. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6557

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Gene

Symbol
SLC12A1
HGNC
Name
solute carrier family 12 member 1
HGNC
NCBI Gene ID
6557
NCBI Gene
HGNC ID
HGNC:10910
HGNC
Ensembl
ENSG00000074803
NCBI Gene
Aliases
BSC, BSC-1, BSC1, CCC2, NKCC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13621Solute carrier family 12 member 11,0990Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463996Q13621Espacenet
JP 2026004568 A2026-01-1464000Q13621Espacenet
EP 4641201 A22025-10-2910717Q13621Espacenet
JP 2025529142 A2025-09-043988Q13621Espacenet
US 12371689 B22025-07-293988Q13621Espacenet
JP 2025517969 A2025-06-1210717Q13621Espacenet
US 11446398 B22022-09-2080400Q13621Espacenet
US 11446398 B22022-09-2080403Q13621Espacenet
US 11400116 B22022-08-0298Q13621Espacenet
JP 2022524081 A2022-04-27183371Q13621Espacenet

1 to 10 of 21

See all 21 patents

Drugs5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BUMETANIDECHEMBL1072Sodium-(potassium)-chloride cotransporter 2 inhibitorINHIBITORChEMBL
ETHACRYNATE SODIUMCHEMBL1200487Sodium-(potassium)-chloride cotransporter 2 inhibitorINHIBITORChEMBL
ETHACRYNIC ACIDCHEMBL456Sodium-(potassium)-chloride cotransporter 2 inhibitorINHIBITORChEMBL
FUROSEMIDECHEMBL35Sodium-(potassium)-chloride cotransporter 2 inhibitorINHIBITORChEMBL
TORSEMIDECHEMBL1148Sodium-(potassium)-chloride cotransporter 2 inhibitorINHIBITORChEMBL

Trials151

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,699

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC12A1 papersNewest fiscal year
R01DK093501WNK-SPAK signaling in the Distal Nephron222025
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport122025
UL1TR001863Yale Clinical and Translational Science Award82025
ZIAHL001285Solute And Water Transport In Renal Epithelia72025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025
I01BX000893Role of M1 Cytokines in the Progression of Chronic Kidney Disease52025
P30CA068485Cancer Center Support Grant52025
R01DK110358Regulation of WNK signaling by potassium and Mo25: structure, function and physiology52025
R01DK110375Coordinated SLC12A3/SLC12A6/SL26A4 electroneutral transport pathways maintain K+ homeostasis and acid-base balance52025
R01DK112042Glomerular and Tubular Function in the Diabetic Kidney52025

1 to 10 of 1,699Source NIH's project files

See all 1,699 nih grants

Papers2,541

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Machine learning identification of biomarkers for vascular endothelial damage in obstructive sleep apnea.Clinics (Sao Paulo)202642784876PubTator, text miningPubMed
Comparing Loop Diuretics: Furosemide Versus Bumetanide.Cardiol Rev202642664023PubTator, text miningPubMed
Phosphorylated MLKL is increased in urinary extracellular vesicles of women with preeclampsia.Pregnancy Hypertens202642632340PubTator, text miningPubMed
UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study.Clin Pharmacol Ther202642559921PubTator, text miningPubMed
Magnesium and blood pressure regulation: systemic and renal mechanisms.Hypertens Res202642552400PubTator, text miningPubMed
Sex-specific molecular signatures in persistent pain after whiplash injury: an exploratory analysis.Pain Rep202642549461PubTator, text miningPubMed
Comparative Assessment of DNA Force Fields for Small-Molecule Ligand Binding via Multicanonical MD-Based Dynamic Docking Simulations.J Chem Theory Comput202642503831PubTator, text miningPubMed
Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors.Front Chem202642466359PubTator, text miningPubMed
Sex differences in renal acid-base regulation.Curr Opin Nephrol Hypertens202642396848PubTator, text miningPubMed
Revealing Antihypertensive Drugs for Reducing NAFLD Risk: Genetic Evidence from a Mendelian Randomization Study.Curr Med Chem202642367123PubTator, text miningPubMed

1 to 10 of 2,541

See all 2,541 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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