Gene · 6557
SLC12A1: solute carrier family 12 member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC12A1: solute carrier family 12 member 1. Genes, record 6557. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6557
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13621 | Solute carrier family 12 member 1 | 1,099 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 63996 | Q13621 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 64000 | Q13621 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10717 | Q13621 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3988 | Q13621 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3988 | Q13621 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10717 | Q13621 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80400 | Q13621 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80403 | Q13621 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 98 | Q13621 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183371 | Q13621 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs5
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BUMETANIDE | CHEMBL1072 | Sodium-(potassium)-chloride cotransporter 2 inhibitor | INHIBITOR | ChEMBL |
| ETHACRYNATE SODIUM | CHEMBL1200487 | Sodium-(potassium)-chloride cotransporter 2 inhibitor | INHIBITOR | ChEMBL |
| ETHACRYNIC ACID | CHEMBL456 | Sodium-(potassium)-chloride cotransporter 2 inhibitor | INHIBITOR | ChEMBL |
| FUROSEMIDE | CHEMBL35 | Sodium-(potassium)-chloride cotransporter 2 inhibitor | INHIBITOR | ChEMBL |
| TORSEMIDE | CHEMBL1148 | Sodium-(potassium)-chloride cotransporter 2 inhibitor | INHIBITOR | ChEMBL |
Trials151
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07596329 | FUROSEMIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07469722 | FUROSEMIDE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07348510 | FUROSEMIDE | ClinicalTrials.gov | ||
| NCT07336485 | FUROSEMIDE | ClinicalTrials.gov | ||
| NCT07286409 | FUROSEMIDE | ClinicalTrials.gov | ||
| NCT07223502 | TORSEMIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07018297 | FUROSEMIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07008365 | FUROSEMIDE | PHASE3 | ClinicalTrials.gov | |
| NCT07005414 | BUMETANIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06995144 | TORSEMIDE | PHASE4 | ClinicalTrials.gov |
1 to 10 of 151
See all 151 trialsNIH grants1,699
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC12A1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 22 | 2025 |
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 12 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| ZIAHL001285 | Solute And Water Transport In Renal Epithelia | 7 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 6 | 2025 |
| I01BX000893 | Role of M1 Cytokines in the Progression of Chronic Kidney Disease | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| R01DK110358 | Regulation of WNK signaling by potassium and Mo25: structure, function and physiology | 5 | 2025 |
| R01DK110375 | Coordinated SLC12A3/SLC12A6/SL26A4 electroneutral transport pathways maintain K+ homeostasis and acid-base balance | 5 | 2025 |
| R01DK112042 | Glomerular and Tubular Function in the Diabetic Kidney | 5 | 2025 |
1 to 10 of 1,699Source NIH's project files
See all 1,699 nih grantsPapers2,541
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Machine learning identification of biomarkers for vascular endothelial damage in obstructive sleep apnea. | Clinics (Sao Paulo) | 2026 | 42784876 | PubTator, text mining | PubMed |
| Comparing Loop Diuretics: Furosemide Versus Bumetanide. | Cardiol Rev | 2026 | 42664023 | PubTator, text mining | PubMed |
| Phosphorylated MLKL is increased in urinary extracellular vesicles of women with preeclampsia. | Pregnancy Hypertens | 2026 | 42632340 | PubTator, text mining | PubMed |
| UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study. | Clin Pharmacol Ther | 2026 | 42559921 | PubTator, text mining | PubMed |
| Magnesium and blood pressure regulation: systemic and renal mechanisms. | Hypertens Res | 2026 | 42552400 | PubTator, text mining | PubMed |
| Sex-specific molecular signatures in persistent pain after whiplash injury: an exploratory analysis. | Pain Rep | 2026 | 42549461 | PubTator, text mining | PubMed |
| Comparative Assessment of DNA Force Fields for Small-Molecule Ligand Binding via Multicanonical MD-Based Dynamic Docking Simulations. | J Chem Theory Comput | 2026 | 42503831 | PubTator, text mining | PubMed |
| Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors. | Front Chem | 2026 | 42466359 | PubTator, text mining | PubMed |
| Sex differences in renal acid-base regulation. | Curr Opin Nephrol Hypertens | 2026 | 42396848 | PubTator, text mining | PubMed |
| Revealing Antihypertensive Drugs for Reducing NAFLD Risk: Genetic Evidence from a Mendelian Randomization Study. | Curr Med Chem | 2026 | 42367123 | PubTator, text mining | PubMed |
1 to 10 of 2,541
See all 2,541 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6557
GET https://conductscience.org/api/genes/v1/6557/patents?page=2