Gene · 6558
SLC12A2: solute carrier family 12 member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC12A2: solute carrier family 12 member 2. Genes, record 6558. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6558
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P55011 | Solute carrier family 12 member 2 | 1,212 | 14 | Ensembl, GeneID, HGNC |
Source UniProt
Patents79
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 395 | P55011 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 64002 | P55011 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2076 | P55011 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1638 | P55011 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3989 | P55011 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3989 | P55011 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1638 | P55011 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2076 | P55011 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35715 | P55011 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35715 | P55011 | Espacenet |
1 to 10 of 79
See all 79 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,858
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC12A2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 22 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 8 | 2025 |
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| I01BX002891 | SPAK inhibitor ZT-1a for ischemic stroke therapy | 6 | 2025 |
| P30DK034989 | Yale Liver Center | 6 | 2025 |
| R01NS048216 | Na/H Exchanger in Microglial Metabolism and Function | 6 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 5 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 4 | 2025 |
1 to 10 of 1,858Source NIH's project files
See all 1,858 nih grantsPapers2,616
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| GABA Signaling in Glioma: Paradoxes and Therapeutic Perspectives. | Curr Neuropharmacol | 2026 | 42786845 | PubTator, text mining | PubMed |
| Mutation Spectrum and Novel Rare Variants in a Han Chinese Hearing Loss Cohort Using a Tiered Sequencing Strategy. | Mol Genet Genomic Med | 2026 | 42764263 | PubTator, text mining | PubMed |
| Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature. | Cell Commun Signal | 2026 | 42717359 | PubTator, text mining | PubMed |
| Development of diversified HTS cell-based assays for solute carrier drug discovery. | SLAS Discov | 2026 | 42648491 | PubTator, text mining | PubMed |
| WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior. | Proc Natl Acad Sci U S A | 2026 | 42640800 | PubTator, text mining | PubMed |
| Functional Reelin signaling deficits without interneuron loss are associated with neuroblast misplacement after non-convulsive status epilepticus. | Neurobiol Dis | 2026 | 42637105 | PubTator, text mining | PubMed |
| Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging. | Cell Signal | 2026 | 42636949 | PubTator, text mining | PubMed |
| Improved Apocrine-Pilosebaceous Unit Extraction Technique for the Treatment of Axillary Bromhidrosis. | Aesthetic Plast Surg | 2026 | 42521784 | PubTator, text mining | PubMed |
| Genetic associations with pulmonary embolism among those with a deep vein thrombosis: the International Network Against Venous Thrombosis Consortium. | J Thromb Haemost | 2026 | 42508647 | PubTator, text mining | PubMed |
| Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors. | Front Chem | 2026 | 42466359 | PubTator, text mining | PubMed |
1 to 10 of 2,616
See all 2,616 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6558
GET https://conductscience.org/api/genes/v1/6558/patents?page=2