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Gene · 6558

SLC12A2: solute carrier family 12 member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC12A2: solute carrier family 12 member 2. Genes, record 6558. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6558

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Gene

Symbol
SLC12A2
HGNC
Name
solute carrier family 12 member 2
HGNC
NCBI Gene ID
6558
NCBI Gene
HGNC ID
HGNC:10911
HGNC
Ensembl
ENSG00000064651
NCBI Gene
Aliases
BSC, BSC-2, BSC2, CCC1, KILQS, NKCC1, PPP1R141, hNKCC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P55011Solute carrier family 12 member 21,21214Ensembl, GeneID, HGNC

Source UniProt

Patents79

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21395P55011Espacenet
JP 2026004568 A2026-01-1464002P55011Espacenet
EP 4650780 A22025-11-192076P55011Espacenet
EP 4641201 A22025-10-291638P55011Espacenet
JP 2025529142 A2025-09-043989P55011Espacenet
US 12371689 B22025-07-293989P55011Espacenet
JP 2025517969 A2025-06-121638P55011Espacenet
JP 2025517970 A2025-06-122076P55011Espacenet
JP 2025032204 A2025-03-1135715P55011Espacenet
EP 4461818 A22024-11-1335715P55011Espacenet

1 to 10 of 79

See all 79 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,858

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC12A2 papersNewest fiscal year
R01DK093501WNK-SPAK signaling in the Distal Nephron222025
P30DK034854Integrated Epithelial and Muscosal Biology82025
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport82025
UL1TR001863Yale Clinical and Translational Science Award82025
I01BX002891SPAK inhibitor ZT-1a for ischemic stroke therapy62025
P30DK034989Yale Liver Center62025
R01NS048216Na/H Exchanger in Microglial Metabolism and Function62025
P30CA068485Cancer Center Support Grant52025
P30DK056338Texas Medical Center Digestive Diseases Center52025
P30DK020593Vanderbilt Diabetes Research Center42025

1 to 10 of 1,858Source NIH's project files

See all 1,858 nih grants

Papers2,616

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
GABA Signaling in Glioma: Paradoxes and Therapeutic Perspectives.Curr Neuropharmacol202642786845PubTator, text miningPubMed
Mutation Spectrum and Novel Rare Variants in a Han Chinese Hearing Loss Cohort Using a Tiered Sequencing Strategy.Mol Genet Genomic Med202642764263PubTator, text miningPubMed
Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature.Cell Commun Signal202642717359PubTator, text miningPubMed
Development of diversified HTS cell-based assays for solute carrier drug discovery.SLAS Discov202642648491PubTator, text miningPubMed
WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior.Proc Natl Acad Sci U S A202642640800PubTator, text miningPubMed
Functional Reelin signaling deficits without interneuron loss are associated with neuroblast misplacement after non-convulsive status epilepticus.Neurobiol Dis202642637105PubTator, text miningPubMed
Dkk3-Cyp11b2/aldosterone signaling couples ion-homeostatic failure to mitochondrial apoptosis in cochlear aging.Cell Signal202642636949PubTator, text miningPubMed
Improved Apocrine-Pilosebaceous Unit Extraction Technique for the Treatment of Axillary Bromhidrosis.Aesthetic Plast Surg202642521784PubTator, text miningPubMed
Genetic associations with pulmonary embolism among those with a deep vein thrombosis: the International Network Against Venous Thrombosis Consortium.J Thromb Haemost202642508647PubTator, text miningPubMed
Synthesis of new sulfoximines and sulfonimidamides derivatives as NKCC1 inhibitors.Front Chem202642466359PubTator, text miningPubMed

1 to 10 of 2,616

See all 2,616 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6558

GET https://conductscience.org/api/genes/v1/6558/patents?page=2