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Gene · 6573

SLC19A1: solute carrier family 19 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC19A1: solute carrier family 19 member 1. Genes, record 6573. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6573

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Gene

Symbol
SLC19A1
HGNC
Name
solute carrier family 19 member 1
HGNC
NCBI Gene ID
6573
NCBI Gene
HGNC ID
HGNC:10937
HGNC
Ensembl
ENSG00000173638
NCBI Gene
Aliases
CHMD, FOLT, IFC-1, IFC1, IMD114, MEGAF, REFC, RFC, RFC1, RFT-1, hRFC, hSLC19A1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41440Reduced folate transporter59119Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194584P41440Espacenet
EP 4641202 A22025-10-29240P41440Espacenet
JP 2025529142 A2025-09-044036P41440Espacenet
US 12371689 B22025-07-294036P41440Espacenet
JP 2025517970 A2025-06-124584P41440Espacenet
JP 2025032204 A2025-03-1135796P41440Espacenet
KR 1020250017231 A2025-02-04240P41440Espacenet
EP 4461818 A22024-11-1335796P41440Espacenet
JP 2024123008 A2024-09-108488P41440Espacenet
JP 2024507735 A2024-02-21146P41440Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,284

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC19A1 papersNewest fiscal year
T32CA009531Training Program in the Biology of Cancer202025
P30CA022453CANCER CENTER SUPPORT GRANT142025
P30CA008748Cancer Center Support Grant122025
P30CA021765Cancer Center Support Grant (CCSG)102025
ZIAHG000167The contribution folate and vitamin B12 genes to disease.72025
P30CA013330Cancer Center Support Grant62025
P30CA016056Roswell Park Cancer Center Support Grant62025
R01CA250469Therapeutic Targeting Mitochondrial C1 Metabolism62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures62025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,284Source NIH's project files

See all 1,284 nih grants

Papers1,999

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Association of solute carrier family 19 member 1 (SLC19A1) A80G polymorphism with the maternal risk for having a child with Down syndrome: A systematic review and meta-analysis.Mutat Res Rev Mutat Res202642762765PubTator, text miningPubMed
Pharmacogenomic variation and chemotherapy-related toxicity profiles in pediatric patients with cancer in Tanzania: a cross-sectional study.Front Pharmacol202642548792PubTator, text miningPubMed
Immunometabolic Stratification of Autism Spectrum Disorder by CD4+ T-Cell Phenotype Reveals Subtype-Specific Energetic Deficit and Coordinated Suppression of Micronutrient Acquisition Pathways.Metabolites202642346396PubTator, text miningPubMed
Functional genomics and proteomics identify Folate Carrier SLC19A1 as a predictor of pralatrexate sensitivity in diverse T-cell lymphoma models.Mol Cancer Ther202642295240PubTator, text miningPubMed
High folate receptor expression is associated with aggressive features in prostate cancer with low prostate-specific membrane antigen expression.BJUI Compass202642255325PubTator, text miningPubMed
Dissecting the role of PCNA and Pif1 in replication of individual DNA molecules by DNA polymerase δ.bioRxiv202642239345PubTator, text miningPubMed
Association of Variants in Candidate Pharmacogenes with Response to Mercaptopurine and Methotrexate in Pediatric Acute Lymphoblastic Leukemia: A Single-Center Experience from Croatia.Oncol Ther202642168754PubTator, text miningPubMed
Extracellular cGAMP in health and disease.Mol Biomed202642106567PubTator, text miningPubMed
Early Erythrocyte Methotrexate Polyglutamate-4 Predicts Treatment Response and Is Influenced by GGH 401C>T Genotype in Patients with Rheumatoid Arthritis.Arch Rheumatol202641989453PubTator, text miningPubMed
Advances in methotrexate nano-formulations to enhance therapeutic efficacy against drug-resistant breast cancer.Discov Nano202641925980PubTator, text miningPubMed

1 to 10 of 1,999

See all 1,999 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6573

GET https://conductscience.org/api/genes/v1/6573/patents?page=2