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Gene · 6580

SLC22A1: solute carrier family 22 member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC22A1: solute carrier family 22 member 1. Genes, record 6580. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6580

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Gene

Symbol
SLC22A1
HGNC
Name
solute carrier family 22 member 1
HGNC
NCBI Gene ID
6580
NCBI Gene
HGNC ID
HGNC:10963
HGNC
Ensembl
ENSG00000175003
NCBI Gene
Aliases
HOCT1, OCT1, oct1_cds
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15245Solute carrier family 22 member 155416Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464184O15245Espacenet
EP 4640849 A22025-10-291232O15245Espacenet
EP 4641201 A22025-10-298299O15245Espacenet
JP 2025529142 A2025-09-044048O15245Espacenet
US 12371689 B22025-07-294048O15245Espacenet
JP 2025519096 A2025-06-241232O15245Espacenet
JP 2025517969 A2025-06-128299O15245Espacenet
US 11446398 B22022-09-2080773O15245Espacenet
US 11400116 B22022-08-022776O15245Espacenet
JP 2022524081 A2022-04-27183744O15245Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,719

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC22A1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant282025
P30ES006694Southwest Environmental Health Sciences Center192025
P30DK026743UCSF Liver Center142025
P30CA021765Cancer Center Support Grant (CCSG)132025
P01CA013106Targeting Transcription and Splicing in Cancer82025
R01HD081299Ontogeny of drug transport82025
R35GM122576Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy82025
R25CA023944PEDIATRIC ONCOLOGY EDUCATION (YEARS 38 - 42)72025
T32ES007091Training in Environmental Toxicology of Human Disease72025
R01DK109392The Role in OAT1 in Uremia62025

1 to 10 of 1,719Source NIH's project files

See all 1,719 nih grants

Papers3,731

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cortisol drives pregnancy-associated induction of hepatic organic anion transporter 2, sodium/taurocholate cotransporting polypeptide, and organic cation transporter 1 in HepaRG cells through glucocorticoid receptor-, hepatocyte nuclear factor 1 alpha-, and hepatocyte nuclear factor 4 alpha-dependent signaling.
Drug Metab Dispos202642685389PubTator, text miningPubMed
Genetically Determined Loss-of-Function of the Organic Cation Transporter OCT1 Is Associated with Lower Liver Fat Content in Humans.Int J Mol Sci202642653422PubTator, text miningPubMed
The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review.Int J Mol Sci202642589662PubTator, text miningPubMed
DNA Methylation of Pharmacologic and Leukemia-Related Genes Predicts Clinical Outcomes in Pediatric Acute Myeloid Leukemia.Cancers (Basel)202642588684PubTator, text miningPubMed
Associative memory plays a role in ER-1α positive breast cancers.Cell Death Differ202642538377PubTator, text miningPubMed
Molecular docking analysis of the interaction between metformin/glimepiride combination and organic cation transporter in diabetic patients.Wiad Lek202642536936PubTator, text miningPubMed
NF-κB/OCT-1 Mediated Upregulation of CXCL14 Chemokine Mobilizes Mucosal Effector Memory CD44+CD62L-CD4+ and CD8+ TEM Cells, and NK Cells Associated with Protection Against Genital Herpes.Pathog Immun202642524223PubTator, text miningPubMed
Transporter gene variants influencing metformin pharmacokinetics and pharmacodynamics common in European populations: a pharmacogenetic narrative review.Front Pharmacol202642403712PubTator, text miningPubMed
Applying molecular dynamics simulations to validate OCT1 substrates uncovers vitamin K1 as a high-affinity ligand.Front Pharmacol202642403708PubTator, text miningPubMed
Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling.bioRxiv202642367899PubTator, text miningPubMed

1 to 10 of 3,731

See all 3,731 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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