Gene · 6580
SLC22A1: solute carrier family 22 member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC22A1: solute carrier family 22 member 1. Genes, record 6580. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6580
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15245 | Solute carrier family 22 member 1 | 554 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64184 | O15245 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1232 | O15245 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8299 | O15245 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4048 | O15245 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4048 | O15245 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1232 | O15245 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8299 | O15245 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80773 | O15245 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 2776 | O15245 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183744 | O15245 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,719
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC22A1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 28 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 19 | 2025 |
| P30DK026743 | UCSF Liver Center | 14 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 13 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 8 | 2025 |
| R01HD081299 | Ontogeny of drug transport | 8 | 2025 |
| R35GM122576 | Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy | 8 | 2025 |
| R25CA023944 | PEDIATRIC ONCOLOGY EDUCATION (YEARS 38 - 42) | 7 | 2025 |
| T32ES007091 | Training in Environmental Toxicology of Human Disease | 7 | 2025 |
| R01DK109392 | The Role in OAT1 in Uremia | 6 | 2025 |
1 to 10 of 1,719Source NIH's project files
See all 1,719 nih grantsPapers3,731
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Cortisol drives pregnancy-associated induction of hepatic organic anion transporter 2, sodium/taurocholate cotransporting polypeptide, and organic cation transporter 1 in HepaRG cells through glucocorticoid receptor-, hepatocyte nuclear factor 1 alpha-, and hepatocyte nuclear factor 4 alpha-dependent signaling. | Drug Metab Dispos | 2026 | 42685389 | PubTator, text mining | PubMed |
| Genetically Determined Loss-of-Function of the Organic Cation Transporter OCT1 Is Associated with Lower Liver Fat Content in Humans. | Int J Mol Sci | 2026 | 42653422 | PubTator, text mining | PubMed |
| The Pharmacogenomics of Opioid Response in Cancer Pain: From Receptor Polymorphisms to Tumour-Mediated Interference-A Narrative-Critical Review. | Int J Mol Sci | 2026 | 42589662 | PubTator, text mining | PubMed |
| DNA Methylation of Pharmacologic and Leukemia-Related Genes Predicts Clinical Outcomes in Pediatric Acute Myeloid Leukemia. | Cancers (Basel) | 2026 | 42588684 | PubTator, text mining | PubMed |
| Associative memory plays a role in ER-1α positive breast cancers. | Cell Death Differ | 2026 | 42538377 | PubTator, text mining | PubMed |
| Molecular docking analysis of the interaction between metformin/glimepiride combination and organic cation transporter in diabetic patients. | Wiad Lek | 2026 | 42536936 | PubTator, text mining | PubMed |
| NF-κB/OCT-1 Mediated Upregulation of CXCL14 Chemokine Mobilizes Mucosal Effector Memory CD44+CD62L-CD4+ and CD8+ TEM Cells, and NK Cells Associated with Protection Against Genital Herpes. | Pathog Immun | 2026 | 42524223 | PubTator, text mining | PubMed |
| Transporter gene variants influencing metformin pharmacokinetics and pharmacodynamics common in European populations: a pharmacogenetic narrative review. | Front Pharmacol | 2026 | 42403712 | PubTator, text mining | PubMed |
| Applying molecular dynamics simulations to validate OCT1 substrates uncovers vitamin K1 as a high-affinity ligand. | Front Pharmacol | 2026 | 42403708 | PubTator, text mining | PubMed |
| Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling. | bioRxiv | 2026 | 42367899 | PubTator, text mining | PubMed |
1 to 10 of 3,731
See all 3,731 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6580
GET https://conductscience.org/api/genes/v1/6580/patents?page=2