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Gene · 6581

SLC22A3: solute carrier family 22 member 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC22A3: solute carrier family 22 member 3. Genes, record 6581. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6581

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Gene

Symbol
SLC22A3
HGNC
Name
solute carrier family 22 member 3
HGNC
NCBI Gene ID
6581
NCBI Gene
HGNC ID
HGNC:10967
HGNC
Ensembl
ENSG00000146477
NCBI Gene
Aliases
EMT, EMTH, OCT3, hOCT3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75751Solute carrier family 22 member 35563Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-29363O75751Espacenet
EP 4641201 A22025-10-292504O75751Espacenet
JP 2025529142 A2025-09-044061O75751Espacenet
US 12371689 B22025-07-294061O75751Espacenet
JP 2025519096 A2025-06-24363O75751Espacenet
JP 2025517969 A2025-06-122504O75751Espacenet
JP 2024123008 A2024-09-108501O75751Espacenet
US 11446398 B22022-09-2080783O75751Espacenet
US 11400116 B22022-08-024857O75751Espacenet
JP 2022524081 A2022-04-27183754O75751Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,190

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC22A3 papersNewest fiscal year
P30DK026743UCSF Liver Center72025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025
P30DK063491Diabetes Research Center (DRC)62025
P30ES006694Southwest Environmental Health Sciences Center52025
P30CA021765Cancer Center Support Grant (CCSG)42025
T32HL007055Cardiovascular Epidemiology Training Grant42025
U24CA247648The Chesapeake-Ohio Pharmacokinetics Core for The ETCTN42025
P2CHD050924Carolina Population Center32025
P30CA006973Regional Oncology Research Center32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,190Source NIH's project files

See all 1,190 nih grants

Papers1,431

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gene Expression Biomarkers for Breast Ductal Carcinoma in Situ Recurrence Prediction.Int J Cancer202642781949PubTator, text miningPubMed
Evodiamine alleviates CUMS-induced depressive-like behaviours associated with modulation of uptake-2 transporters.Xenobiotica202642728579PubTator, text miningPubMed
Transcriptomic meta-analysis identifies dysregulated pathways and potential therapeutic targets in Vestibular Schwannoma.PLoS One202642430393PubTator, text miningPubMed
SLC22A3 regulates ferroptosis in the mesenchymal subtype of triple-negative breast cancer by modulating histone H3K4 serotonylation.Cell Death Dis202642425937PubTator, text miningPubMed
Transporter gene variants influencing metformin pharmacokinetics and pharmacodynamics common in European populations: a pharmacogenetic narrative review.Front Pharmacol202642403712PubTator, text miningPubMed
Interindividual variability in metformin pharmacokinetics in pediatric patients.Pediatr Res202642399684PubTator, text miningPubMed
Identification of high-risk SNPs in SLC22A transporter genes: their potential role in PCOS and metformin uptake.BMC Genom Data202642310538PubTator, text miningPubMed
SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer.Cell Rep202642250222PubTator, text miningPubMed
Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease.Nat Genet202642230773PubTator, text miningPubMed
A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells.Mol Cancer Ther202642227585PubTator, text miningPubMed

1 to 10 of 1,431

See all 1,431 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6581

GET https://conductscience.org/api/genes/v1/6581/patents?page=2