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BMPR2: bone morphogenetic protein receptor type 2

1 protein, 115 patents, 2 drugs, 4 trials, 2,840 NIH grants and 5,101 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBMPR2HGNC
Namebone morphogenetic protein receptor type 2HGNC
NCBI Gene ID659NCBI Gene
HGNC IDHGNC:1078HGNC
EnsemblENSG00000204217NCBI Gene
AliasesBMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALKNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13873Bone morphogenetic protein receptor type-21,0387Ensembl, GeneID, HGNCUniProt

Patents 115

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11188Q13873Espacenet
JP 2026027383 A2026-02-1828Q13873Espacenet
JP 2026004568 A2026-01-1439079Q13873Espacenet
EP 4650780 A22025-11-199485Q13873Espacenet
EP 4641201 A22025-10-299736Q13873Espacenet
EP 4641202 A22025-10-29539Q13873Espacenet
EP 4641203 A22025-10-29278Q13873Espacenet
US 12421295 B22025-09-2346Q13873Espacenet
JP 2025529142 A2025-09-04587Q13873Espacenet
US 12371689 B22025-07-29587Q13873Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIBOTERMIN ALFACHEMBL2109171Bone morphogenetic protein receptor type-2 agonistAGONISTChEMBL
EPTOTERMIN ALFACHEMBL2108594Bone morphogenetic protein receptor type-2 agonistAGONISTChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05911477DIBOTERMIN ALFAClinicalTrials.gov
NCT01133613EPTOTERMIN ALFAPHASE1ClinicalTrials.gov
NCT01111045EPTOTERMIN ALFAPHASE2ClinicalTrials.gov
NCT00456157EPTOTERMIN ALFAPHASE1ClinicalTrials.gov

NIH grants 2840

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL138473BMPR2, Monocytes and Macrophages in Pulmonary Artery Hypertension182,025NIH's project files
P30CA068485Cancer Center Support Grant142,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases122,025NIH's project files
R01HL124021An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH112,025NIH's project files
T32HL129970Stanford Training Program in Lung Biology102,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA92,025NIH's project files
P30CA016672Cancer Center Support Grant82,025NIH's project files
R01HL139613Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertension82,025NIH's project files
P30CA008748Cancer Center Support Grant72,025NIH's project files
R01HL135872Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension72,025NIH's project files

Papers 5101

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821434PubTator, text miningPubMed
42807825PubTator, text miningPubMed
42742019PubTator, text miningPubMed
42732062PubTator, text miningPubMed
42729656PubTator, text miningPubMed
42705706PubTator, text miningPubMed
42679493PubTator, text miningPubMed
42675314PubTator, text miningPubMed
42626541PubTator, text miningPubMed
42614538PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license