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Gene · 6590

SLPI: secretory leukocyte peptidase inhibitor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLPI: secretory leukocyte peptidase inhibitor. Genes, record 6590. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6590

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Gene

Symbol
SLPI
HGNC
Name
secretory leukocyte peptidase inhibitor
HGNC
NCBI Gene ID
6590
NCBI Gene
HGNC ID
HGNC:11092
HGNC
Ensembl
ENSG00000124107
NCBI Gene
Aliases
ALK1, ALP, BLPI, HUSI, HUSI-1, HUSI-I, MPI, WAP4, WFDC4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03973Antileukoproteinase1322Ensembl, GeneID, HGNC

Source UniProt

Patents166

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196706P03973Espacenet
JP 2025147176 A2025-10-0612501P03973Espacenet
JP 2025138725 A2025-09-252206P03973Espacenet
WO 2025191291 A12025-09-183P03973Espacenet
JP 2025529142 A2025-09-047750P03973Espacenet
US 12371689 B22025-07-297750P03973Espacenet
JP 2025517970 A2025-06-126706P03973Espacenet
JP 2025028160 A2025-02-2812501P03973Espacenet
KR 1020250012200 A2025-01-238P03973Espacenet
KR 1020250010750 A2025-01-2112501P03973Espacenet

1 to 10 of 166

See all 166 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,152

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLPI papersNewest fiscal year
P30CA008748Cancer Center Support Grant162025
P30CA023108Cancer Center Support Grant142025
P30CA016672Cancer Center Support Grant122025
P30AI027757University of Washington/Fred Hutch Center for AIDS Research82025
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease62025
T32ES007126Pre- and Postdoctoral Training in Toxicology62025
ZIADE000736Mechanisms of Chronic Inflammation in Periodontitis62025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition62025
P30AI027767UAB Center for AIDS Research (CFAR)52025
P30AI042853Providence/Boston Center for AIDS Research (CFAR)52025

1 to 10 of 2,152Source NIH's project files

See all 2,152 nih grants

Papers3,867

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Loss of Smad4 drives vascular malformations via c-KIT-dependent high-fluid shear stress mimicry.J Clin Invest202642820305PubTator, text miningPubMed
The influence of focused ultrasound in the treatment of cervical squamous intraepithelial lesion on vaginal microbiota and cervical immune microenvironment: a prospective observational study.Int J Hyperthermia202642811769PubTator, text miningPubMed
Enhanced Efficacy of Sandblasted, Large-Grit, Alkaline-Etched (SLA) Titanium Surfaces Combined with Plasma Treatment and Secretory Leukocyte Protease Inhibitor (SLPI) Coating in Promoting Osteoblast Activity and Reducing Bacterial Adhesion.
J Funct Biomater202642783701PubTator, text miningPubMed
Unraveling tumor cell heterogeneity and epithelial-mesenchymal plasticity in gastric adenocarcinoma: an integrative multi-omics framework evaluating PVR/CD155 as a tumor cell-intrinsic EMT-associated target.
Front Immunol202642769440PubTator, text miningPubMed
Identification of immune cell mitochondrial dysfunction characteristics and clinical predictive biomarkers in sepsis via multi-cohort machine learning and single-cell RNA sequencing.Inflamm Res202642762293PubTator, text miningPubMed
Extracellular matrix remodeling and internal elastic lamina alterations in cerebral arteriovenous malformations: Insights into vascular wall biology.Neurosurg Rev202642749821PubTator, text miningPubMed
ALK Expression Without ALK Rearrangement in EWSR1::ATF1-Fused Inflammatory and Nested Testicular Sex Cord Tumor.Diagnostics (Basel)202642739277PubTator, text miningPubMed
A microphysiological system HHT-on-a-chip platform recapitulates patient vascular lesions.Nat Commun202642722664PubTator, text miningPubMed
Single-cell transcriptomics reveals cellular heterogeneity and neoadjuvant chemotherapy response signatures in triple-negative breast cancer.Front Oncol202642687923PubTator, text miningPubMed
SLPI is associated with AR-regulated epithelial adaptation and enzalutamide sensitivity in castration-resistant prostate cancer.Front Pharmacol202642682507PubTator, text miningPubMed

1 to 10 of 3,867

See all 3,867 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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