Gene · 6590
SLPI: secretory leukocyte peptidase inhibitor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLPI: secretory leukocyte peptidase inhibitor. Genes, record 6590. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6590
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P03973 | Antileukoproteinase | 132 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents166
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6706 | P03973 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 12501 | P03973 | Espacenet |
| JP 2025138725 A | 2025-09-25 | 2206 | P03973 | Espacenet |
| WO 2025191291 A1 | 2025-09-18 | 3 | P03973 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7750 | P03973 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7750 | P03973 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6706 | P03973 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 12501 | P03973 | Espacenet |
| KR 1020250012200 A | 2025-01-23 | 8 | P03973 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 12501 | P03973 | Espacenet |
1 to 10 of 166
See all 166 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,152
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLPI papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 16 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 14 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| P30AI027757 | University of Washington/Fred Hutch Center for AIDS Research | 8 | 2025 |
| RM1HG009490 | Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease | 6 | 2025 |
| T32ES007126 | Pre- and Postdoctoral Training in Toxicology | 6 | 2025 |
| ZIADE000736 | Mechanisms of Chronic Inflammation in Periodontitis | 6 | 2025 |
| ZIAHD002400 | The Role Of Subclinical Infection And Cytokines In Preterm Parturition | 6 | 2025 |
| P30AI027767 | UAB Center for AIDS Research (CFAR) | 5 | 2025 |
| P30AI042853 | Providence/Boston Center for AIDS Research (CFAR) | 5 | 2025 |
1 to 10 of 2,152Source NIH's project files
See all 2,152 nih grantsPapers3,867
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Loss of Smad4 drives vascular malformations via c-KIT-dependent high-fluid shear stress mimicry. | J Clin Invest | 2026 | 42820305 | PubTator, text mining | PubMed |
| The influence of focused ultrasound in the treatment of cervical squamous intraepithelial lesion on vaginal microbiota and cervical immune microenvironment: a prospective observational study. | Int J Hyperthermia | 2026 | 42811769 | PubTator, text mining | PubMed |
Enhanced Efficacy of Sandblasted, Large-Grit, Alkaline-Etched (SLA) Titanium Surfaces Combined with Plasma Treatment and Secretory Leukocyte Protease Inhibitor (SLPI) Coating in Promoting Osteoblast Activity and Reducing Bacterial Adhesion. | J Funct Biomater | 2026 | 42783701 | PubTator, text mining | PubMed |
Unraveling tumor cell heterogeneity and epithelial-mesenchymal plasticity in gastric adenocarcinoma: an integrative multi-omics framework evaluating PVR/CD155 as a tumor cell-intrinsic EMT-associated target. | Front Immunol | 2026 | 42769440 | PubTator, text mining | PubMed |
| Identification of immune cell mitochondrial dysfunction characteristics and clinical predictive biomarkers in sepsis via multi-cohort machine learning and single-cell RNA sequencing. | Inflamm Res | 2026 | 42762293 | PubTator, text mining | PubMed |
| Extracellular matrix remodeling and internal elastic lamina alterations in cerebral arteriovenous malformations: Insights into vascular wall biology. | Neurosurg Rev | 2026 | 42749821 | PubTator, text mining | PubMed |
| ALK Expression Without ALK Rearrangement in EWSR1::ATF1-Fused Inflammatory and Nested Testicular Sex Cord Tumor. | Diagnostics (Basel) | 2026 | 42739277 | PubTator, text mining | PubMed |
| A microphysiological system HHT-on-a-chip platform recapitulates patient vascular lesions. | Nat Commun | 2026 | 42722664 | PubTator, text mining | PubMed |
| Single-cell transcriptomics reveals cellular heterogeneity and neoadjuvant chemotherapy response signatures in triple-negative breast cancer. | Front Oncol | 2026 | 42687923 | PubTator, text mining | PubMed |
| SLPI is associated with AR-regulated epithelial adaptation and enzalutamide sensitivity in castration-resistant prostate cancer. | Front Pharmacol | 2026 | 42682507 | PubTator, text mining | PubMed |
1 to 10 of 3,867
See all 3,867 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6590
GET https://conductscience.org/api/genes/v1/6590/patents?page=2