ConductScience.org, home

Gene · 6595

SMARCA2: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. SMARCA2: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2. Genes, record 6595. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6595

On this page

Gene

Symbol
SMARCA2
HGNC
Name
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
HGNC
NCBI Gene ID
6595
NCBI Gene
HGNC ID
HGNC:11098
HGNC
Ensembl
ENSG00000080503
NCBI Gene
Aliases
BAF190, BIS, BRM, NCBRS, SAMRCA2, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51531SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 21,59032Ensembl, GeneID, HGNC

Source UniProt

Patents70

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12534732 B22026-01-27926P51531Espacenet
JP 2026012378 A2026-01-23926P51531Espacenet
JP 2026004568 A2026-01-1465954P51531Espacenet
JP 2026004568 A2026-01-1465961P51531Espacenet
US 12516329 B22026-01-06926P51531Espacenet
EP 4670792 A22025-12-31926P51531Espacenet
EP 4650780 A22025-11-192525P51531Espacenet
KR 1020250160362 A2025-11-12926P51531Espacenet
JP 2025164846 A2025-10-304P51531Espacenet
EP 4641201 A22025-10-292113P51531Espacenet

1 to 10 of 70

See all 70 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,767

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMARCA2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant362025
P30CA016672Cancer Center Support Grant262025
R01CA163915ATP-Dependent Chromatin Remodeling in Human Malignancy152025
P30CA016058Cancer Center Support Grant142025
R01CA113794The function of Snf5 (SMARCB1), an epigenetic tumor suppressor132025
ZIAES071006Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells122025
P30CA016086Cancer Center Support Grant112025
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension112025
U24CA196171The Alliance NCTN Biorepository and Biospecimen Resource112025
U10CA180882Alliance Statistics and Data Management Center102025

1 to 10 of 2,767Source NIH's project files

See all 2,767 nih grants

Papers3,459

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pro-GAT: Reconnecting Fragmented PROTACs Using Graph Attention Transformer.J Chem Inf Model202642734562PubTator, text miningPubMed
Abscisic acid-regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation of CmHSFA4.Sci Adv202642627904PubTator, text miningPubMed
Novel Compounds as SMARCA2 Inhibitors for Treating Non-small Cell Lung Cancer.ACS Med Chem Lett202642621530PubTator, text miningPubMed
The Pan-tumor Landscape, Allelic Status, and Genomic Complexity of SMARCA4 Alterations.Clin Cancer Res202642599160PubTator, text miningPubMed
Diagnostic Pitfall in Genomic Era: Discordant SMARCA2 Finding in Patient with Megalencephalic Leukoencephalopathy with Subcortical Cysts.Diagnostics (Basel)202642587552PubTator, text miningPubMed
EZH1/2 inhibition selectively targets SMARCA4/2 co-deficient lung cancer cells by suppressing stemness and proliferation.Neoplasia202642567102PubTator, text miningPubMed
Genotypic and Phenotypic Profile of 50 Cases With Chromatin Remodeling Complexes-Related Neurological Disorders.CNS Neurosci Ther202642528014PubTator, text miningPubMed
Characterizing ARID1B-related disorders and variants of uncertain significance using DNA methylation.Eur J Hum Genet202642527582PubTator, text miningPubMed
SMARCA2 and SMARCA4-deficiency is associated with a distinct molecular and microenvironmental subtype of esophageal adenocarcinoma.Sci Rep202642527418PubTator, text miningPubMed
Histone Methylation and Chromatin Remodeling in Non-Small Cell Lung Cancer: Mechanisms of Oncogenesis and Emerging Therapeutic Strategies.Biomedicines202642512002PubTator, text miningPubMed

1 to 10 of 3,459

See all 3,459 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6595

GET https://conductscience.org/api/genes/v1/6595/patents?page=2