Gene · 6595
SMARCA2: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMARCA2: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2. Genes, record 6595. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6595
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51531 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 | 1,590 | 32 | Ensembl, GeneID, HGNC |
Source UniProt
Patents70
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12534732 B2 | 2026-01-27 | 926 | P51531 | Espacenet |
| JP 2026012378 A | 2026-01-23 | 926 | P51531 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65954 | P51531 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 65961 | P51531 | Espacenet |
| US 12516329 B2 | 2026-01-06 | 926 | P51531 | Espacenet |
| EP 4670792 A2 | 2025-12-31 | 926 | P51531 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2525 | P51531 | Espacenet |
| KR 1020250160362 A | 2025-11-12 | 926 | P51531 | Espacenet |
| JP 2025164846 A | 2025-10-30 | 4 | P51531 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2113 | P51531 | Espacenet |
1 to 10 of 70
See all 70 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,767
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMARCA2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 36 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 26 | 2025 |
| R01CA163915 | ATP-Dependent Chromatin Remodeling in Human Malignancy | 15 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 14 | 2025 |
| R01CA113794 | The function of Snf5 (SMARCB1), an epigenetic tumor suppressor | 13 | 2025 |
| ZIAES071006 | Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells | 12 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 11 | 2025 |
| U10CA180821 | Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension | 11 | 2025 |
| U24CA196171 | The Alliance NCTN Biorepository and Biospecimen Resource | 11 | 2025 |
| U10CA180882 | Alliance Statistics and Data Management Center | 10 | 2025 |
1 to 10 of 2,767Source NIH's project files
See all 2,767 nih grantsPapers3,459
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Pro-GAT: Reconnecting Fragmented PROTACs Using Graph Attention Transformer. | J Chem Inf Model | 2026 | 42734562 | PubTator, text mining | PubMed |
| Abscisic acid-regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation of CmHSFA4. | Sci Adv | 2026 | 42627904 | PubTator, text mining | PubMed |
| Novel Compounds as SMARCA2 Inhibitors for Treating Non-small Cell Lung Cancer. | ACS Med Chem Lett | 2026 | 42621530 | PubTator, text mining | PubMed |
| The Pan-tumor Landscape, Allelic Status, and Genomic Complexity of SMARCA4 Alterations. | Clin Cancer Res | 2026 | 42599160 | PubTator, text mining | PubMed |
| Diagnostic Pitfall in Genomic Era: Discordant SMARCA2 Finding in Patient with Megalencephalic Leukoencephalopathy with Subcortical Cysts. | Diagnostics (Basel) | 2026 | 42587552 | PubTator, text mining | PubMed |
| EZH1/2 inhibition selectively targets SMARCA4/2 co-deficient lung cancer cells by suppressing stemness and proliferation. | Neoplasia | 2026 | 42567102 | PubTator, text mining | PubMed |
| Genotypic and Phenotypic Profile of 50 Cases With Chromatin Remodeling Complexes-Related Neurological Disorders. | CNS Neurosci Ther | 2026 | 42528014 | PubTator, text mining | PubMed |
| Characterizing ARID1B-related disorders and variants of uncertain significance using DNA methylation. | Eur J Hum Genet | 2026 | 42527582 | PubTator, text mining | PubMed |
| SMARCA2 and SMARCA4-deficiency is associated with a distinct molecular and microenvironmental subtype of esophageal adenocarcinoma. | Sci Rep | 2026 | 42527418 | PubTator, text mining | PubMed |
| Histone Methylation and Chromatin Remodeling in Non-Small Cell Lung Cancer: Mechanisms of Oncogenesis and Emerging Therapeutic Strategies. | Biomedicines | 2026 | 42512002 | PubTator, text mining | PubMed |
1 to 10 of 3,459
See all 3,459 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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GET https://conductscience.org/api/genes/v1/6595/patents?page=2