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SMN1: survival of motor neuron 1, telomeric

1 protein, 140 patents, 1 drug, 13 trials, 6,092 NIH grants and 17,309 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSMN1HGNC
Namesurvival of motor neuron 1, telomericHGNC
NCBI Gene ID6606NCBI Gene
HGNC IDHGNC:11117HGNC
EnsemblENSG00000172062NCBI Gene
AliasesBCD541, GEMIN1, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, TDRD16ANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q16637Survival motor neuron protein29415Ensembl, GeneID, HGNCUniProt

Patents 140

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086420 A2026-05-2633Q16637Espacenet
EP 4704920 A12026-03-11137Q16637Espacenet
JP 2026004568 A2026-01-1465920Q16637Espacenet
JP 2026004568 A2026-01-1465927Q16637Espacenet
US 12478692 B22025-11-253Q16637Espacenet
EP 4650780 A22025-11-1910364Q16637Espacenet
EP 4650780 A22025-11-194377Q16637Espacenet
EP 4585229 A22025-07-162Q16637Espacenet
EP 4585263 A22025-07-162Q16637Espacenet
US 12350311 B22025-07-082Q16637Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ONASEMNOGENE ABEPARVOVECCHEMBL4297240Survival motor neuron protein exogenous geneEXOGENOUS GENEChEMBL

Trials 13

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07444450ONASEMNOGENE ABEPARVOVECPHASE3ClinicalTrials.gov
NCT05769465ONASEMNOGENE ABEPARVOVECClinicalTrials.gov
NCT05680233ONASEMNOGENE ABEPARVOVECPHASE1ClinicalTrials.gov
NCT05335876ONASEMNOGENE ABEPARVOVECPHASE3ClinicalTrials.gov
NCT04174157ONASEMNOGENE ABEPARVOVECClinicalTrials.gov
NCT04042025ONASEMNOGENE ABEPARVOVECPHASE3ClinicalTrials.gov
NCT03837184ONASEMNOGENE ABEPARVOVECPHASE32022-01-11ClinicalTrials.gov
NCT03505099ONASEMNOGENE ABEPARVOVECPHASE32022-01-11ClinicalTrials.gov
NCT03461289ONASEMNOGENE ABEPARVOVECPHASE32021-04-02ClinicalTrials.gov
NCT03421977ONASEMNOGENE ABEPARVOVECClinicalTrials.gov

NIH grants 6092

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1042,025NIH's project files
P30CA016672Cancer Center Support Grant342,025NIH's project files
P50CA217694SPORE in Soft Tissue Sarcoma262,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award222,025NIH's project files
R01NS102451RNA-Mediated Mechanisms of Motor System Dysfunction in Spinal Muscular Atrophy202,025NIH's project files
P40OD010440Caenorhabditis Genetics Center192,025NIH's project files
R01NS078375Mechanisms of Central Synaptic Dysfunction in SMA152,025NIH's project files
R01GM042699Biochemistry of Pre-mRNA Splicing142,025NIH's project files
P30CA045508CSHL Cancer Center Support Grant122,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102,025NIH's project files

Papers 17309

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827317PubTator, text miningPubMed
42826493PubTator, text miningPubMed
42817960PubTator, text miningPubMed
42812127PubTator, text miningPubMed
42812016PubTator, text miningPubMed
42807701PubTator, text miningPubMed
42806960PubTator, text miningPubMed
42798874PubTator, text miningPubMed
42794238PubTator, text miningPubMed
42792736PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license