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SMO: smoothened, frizzled class receptor

1 protein, 88 patents, 10 drugs, 158 trials, 3,312 NIH grants and 7,213 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSMOHGNC
Namesmoothened, frizzled class receptorHGNC
NCBI Gene ID6608NCBI Gene
HGNC IDHGNC:11119HGNC
EnsemblENSG00000128602NCBI Gene
AliasesCRJS, FZD11, Gx, PHLS, SMOHNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q99835Protein smoothened78715Ensembl, GeneID, HGNCUniProt

Patents 88

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191276Q99835Espacenet
EP 4640849 A22025-10-29142Q99835Espacenet
EP 4641201 A22025-10-29909Q99835Espacenet
KR 1020250141897 A2025-09-3015Q99835Espacenet
JP 2025529142 A2025-09-044380Q99835Espacenet
US 12371689 B22025-07-294380Q99835Espacenet
JP 2025519096 A2025-06-24142Q99835Espacenet
JP 2025517969 A2025-06-12909Q99835Espacenet
JP 2025517970 A2025-06-121276Q99835Espacenet
EP 4442711 A12024-10-0940Q99835Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BMS-833923CHEMBL3545403Smoothened homolog antagonistANTAGONISTChEMBL
GLASDEGIBCHEMBL2043437Smoothened homolog antagonistANTAGONISTChEMBL
GLASDEGIB MALEATECHEMBL4297534Smoothened homolog antagonistANTAGONISTChEMBL
LEQ506CHEMBL3133037Smoothened homolog antagonistANTAGONISTChEMBL
PATIDEGIBCHEMBL538867Smoothened homolog antagonistANTAGONISTChEMBL
SONIDEGIBCHEMBL2105737Smoothened homolog inhibitorINHIBITORChEMBL
SONIDEGIB PHOSPHATECHEMBL3137317Smoothened homolog inhibitorINHIBITORChEMBL
TAK-441CHEMBL2205230Smoothened homolog antagonistANTAGONISTChEMBL
TALADEGIBCHEMBL2142592Smoothened homolog antagonistANTAGONISTChEMBL
VISMODEGIBCHEMBL473417Smoothened homolog inhibitorINHIBITORChEMBL

Trials 158

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07068568SONIDEGIBClinicalTrials.gov
NCT06880848SONIDEGIBPHASE4ClinicalTrials.gov
NCT06623201SONIDEGIBPHASE1ClinicalTrials.gov
NCT06616623VISMODEGIBPHASE1ClinicalTrials.gov
NCT06422884TALADEGIBPHASE2ClinicalTrials.gov
NCT06357988VISMODEGIBPHASE2ClinicalTrials.gov
NCT06344052VISMODEGIBPHASE2ClinicalTrials.gov
NCT05669339SONIDEGIBPHASE2ClinicalTrials.gov
NCT05651828VISMODEGIBEARLY_PHASE1ClinicalTrials.gov
NCT05561634VISMODEGIBPHASE2ClinicalTrials.gov

NIH grants 3312

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant472,025NIH's project files
P30CA008748Cancer Center Support Grant452,025NIH's project files
P30CA006973Regional Oncology Research Center282,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)252,025NIH's project files
R01AR046786Stromal Regulation of Basal Cell Carcinoma Formation242,025NIH's project files
R35GM118082Signal transduction in development and disease192,025NIH's project files
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma182,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award182,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028162,025NIH's project files
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN152,025NIH's project files

Papers 7213

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42745824PubTator, text miningPubMed
42737762PubTator, text miningPubMed
42689059PubTator, text miningPubMed
42667406PubTator, text miningPubMed
42650885PubTator, text miningPubMed
42650114PubTator, text miningPubMed
42552286PubTator, text miningPubMed
42523455PubTator, text miningPubMed
42511667PubTator, text miningPubMed
42470490PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license