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Gene · 6610

SMPD2: sphingomyelin phosphodiesterase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMPD2: sphingomyelin phosphodiesterase 2. Genes, record 6610. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6610

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Gene

Symbol
SMPD2
HGNC
Name
sphingomyelin phosphodiesterase 2
HGNC
NCBI Gene ID
6610
NCBI Gene
HGNC ID
HGNC:11121
HGNC
Ensembl
ENSG00000135587
NCBI Gene
Aliases
ISC1, NSMASE, NSMASE1, nSMase
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O60906Sphingomyelin phosphodiesterase 24231Ensembl, GeneID, HGNC

Source UniProt

Patents11

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-291272O60906Espacenet
JP 2025529142 A2025-09-044382O60906Espacenet
US 12371689 B22025-07-294382O60906Espacenet
JP 2025517969 A2025-06-121272O60906Espacenet
US 11446398 B22022-09-2083404O60906Espacenet
US 11400116 B22022-08-022781O60906Espacenet
JP 2022524081 A2022-04-27186375O60906Espacenet
US 11078247 B22021-08-0310706O60906Espacenet
JP 2017121240 A2017-07-1354588O60906Espacenet
JP 2015518704 A2015-07-0654588O60906Espacenet

1 to 10 of 11

See all 11 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,131

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMPD2 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy282025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant102025
P30MH075673JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)102025
R35GM118128Neutral Sphingomyelinases and Bioactive Ceramides82025
P30DK056341Washington University Nutrition Obesity Research Center62025
P50AA011999Southern California Research Center for ALPD and Cirrhosis52025
R01CA218678Ceramide Activated Protein Phosphatases52025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy52025
P30DK020579Diabetes Research Center42025
I01BX004893Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction32025

1 to 10 of 1,131Source NIH's project files

See all 1,131 nih grants

Papers1,725

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Sphingolipid Metabolism Links Morphological Signatures to Immunomodulatory Potency in Human Mesenchymal Stromal Cells.Cell Mol Bioeng202642729496PubTator, text miningPubMed
CD1a-autoreactive T cell sensing of skin barrier compromise.Br J Dermatol202642710064PubTator, text miningPubMed
[Laryngeal squamous cell carcinoma-derived exosomes promote neuronal axonal growth by remodeling the neural microenvironment].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi202642706064PubTator, text miningPubMed
Lipid-manager autophagy proteins ATG2 and ATG9 regulate extracellular vesicle secretion via amphisome biogenesis and cell lipidome modulation.Nat Commun202642637773PubTator, text miningPubMed
Endothelial-derived extracellular vesicles impair human pulmonary microvascular cell function in an in vitro model of sepsis-induced acute lung injury.Am J Physiol Lung Cell Mol Physiol202642467463PubTator, text miningPubMed
Tumor-associated macrophage-derived exosomes promote radio-resistance in nasopharyngeal carcinoma cells accompanied by suppression of the cGAS/STING pathway.Int J Radiat Biol202642313148PubTator, text miningPubMed
Sphingolipid homeostasis and dysregulation in liver function and disease.Life Metab202642239544PubTator, text miningPubMed
Inhibition of sphingomyelinase blocks the recruitment of alkaline phosphatase to mineralization-competent matrix vesicles.Bone202642107620PubTator, text miningPubMed
Glioblastoma Cells Expressing Oncogenic EGFR Release Multiple Extracellular Vesicle Subpopulations Positive or Negative for EGFR.J Extracell Biol202641953752PubTator, text miningPubMed
Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity.Elife202641925724PubTator, text miningPubMed

1 to 10 of 1,725

See all 1,725 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6610

GET https://conductscience.org/api/genes/v1/6610/patents