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Gene · 6611

SMS: spermine synthase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMS: spermine synthase. Genes, record 6611. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6611

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Gene

Symbol
SMS
HGNC
Name
spermine synthase
HGNC
NCBI Gene ID
6611
NCBI Gene
HGNC ID
HGNC:11123
HGNC
Ensembl
ENSG00000102172
NCBI Gene
Aliases
MRSR, MRXSSR, SPMSY, SRS, SpS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P52788Spermine synthase3662Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465261P52788Espacenet
EP 4641202 A22025-10-296080P52788Espacenet
KR 1020250017231 A2025-02-046080P52788Espacenet
US 11446398 B22022-09-2083352P52788Espacenet
JP 2022524081 A2022-04-27186323P52788Espacenet
JP 2019054813 A2019-04-11245696P52788Espacenet
JP 2017121241 A2017-07-13245696P52788Espacenet
JP 2015516143 A2015-06-08245696P52788Espacenet
US 8586006 B22013-11-1910583P52788Espacenet
EP 2450456 A22012-05-09182P52788Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants748

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMS papersNewest fiscal year
P01CA116087H. pylori-induced Inflammation and Gastric Cancer92025
P30DK058404Molecular and Cellular Basis for Digestive Diseases92025
P01CA097132Sphingolipids in Cancer Biology and Therapy82025
R01HD110500Leveraging modulation of polyamine metabolism for therapeutic advantage in genetic disorders62025
I01BX000900Effect of SMSr on VLDL metabolism and atherosclerosis52025
P30CA006973Regional Oncology Research Center52025
P30CA016672Cancer Center Support Grant52025
P30CA076292Moffitt Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant42025
R01DE016572Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy42025

1 to 10 of 748Source NIH's project files

See all 748 nih grants

Papers1,316

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatial Association Between Polyamine Metabolism and Lipid Peroxidation in Different Pathological Regions of Glioblastoma.Biomedicines202642792811PubTator, text miningPubMed
Ceramide 1-phosphate binding proteins: emerging regulators of cell physiology and disease.Biochem Cell Biol202642715607PubTator, text miningPubMed
Polyamine Metabolism in Brain Health and Disease.Neuropharmacol Ther202642631064PubTator, text miningPubMed
Polyamines buffer labile iron to suppress ferroptosis.Cell202642600612PubTator, text miningPubMed
Metabolic-immunoregulatory subtypes reveal prognostic and therapeutic insights in multiple primary lung cancer.Front Immunol202642528797PubTator, text miningPubMed
A salivary protein panel for detecting malignant transformation of oral leukoplakia.Oral Oncol202642385552PubTator, text miningPubMed
Hypoxia Remodels the Extracellular Vesicle Proteome to Drive Metastasis in Breast Cancer via Metabolic-Epigenetic Coupling.J Proteome Res202642341239PubTator, text miningPubMed
Integrated single-cell and bulk RNA-seq analysis identifies BCAA metabolism-related prognostic signatures in head and neck squamous cell carcinoma.Immunobiology202642263482PubTator, text miningPubMed
Integrated transcriptomics, network pharmacology and clinical expression validation reveal the prognostic significance of PANoptosis-related genes in cordycepin-treated lung adenocarcinoma.Discov Oncol202642260221PubTator, text miningPubMed
Metabolic alterations in Snyder-Robinson syndrome lymphoblasts are ameliorated by phenylbutyrate treatment.Mol Genet Metab202642250346PubTator, text miningPubMed

1 to 10 of 1,316

See all 1,316 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6611

GET https://conductscience.org/api/genes/v1/6611/patents?page=2