Gene · 6611
SMS: spermine synthase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SMS: spermine synthase. Genes, record 6611. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6611
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P52788 | Spermine synthase | 366 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65261 | P52788 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 6080 | P52788 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 6080 | P52788 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83352 | P52788 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 186323 | P52788 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 245696 | P52788 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 245696 | P52788 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 245696 | P52788 | Espacenet |
| US 8586006 B2 | 2013-11-19 | 10583 | P52788 | Espacenet |
| EP 2450456 A2 | 2012-05-09 | 182 | P52788 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants748
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SMS papers | Newest fiscal year |
|---|---|---|---|
| P01CA116087 | H. pylori-induced Inflammation and Gastric Cancer | 9 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 9 | 2025 |
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 8 | 2025 |
| R01HD110500 | Leveraging modulation of polyamine metabolism for therapeutic advantage in genetic disorders | 6 | 2025 |
| I01BX000900 | Effect of SMSr on VLDL metabolism and atherosclerosis | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| R01DE016572 | Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy | 4 | 2025 |
1 to 10 of 748Source NIH's project files
See all 748 nih grantsPapers1,316
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatial Association Between Polyamine Metabolism and Lipid Peroxidation in Different Pathological Regions of Glioblastoma. | Biomedicines | 2026 | 42792811 | PubTator, text mining | PubMed |
| Ceramide 1-phosphate binding proteins: emerging regulators of cell physiology and disease. | Biochem Cell Biol | 2026 | 42715607 | PubTator, text mining | PubMed |
| Polyamine Metabolism in Brain Health and Disease. | Neuropharmacol Ther | 2026 | 42631064 | PubTator, text mining | PubMed |
| Polyamines buffer labile iron to suppress ferroptosis. | Cell | 2026 | 42600612 | PubTator, text mining | PubMed |
| Metabolic-immunoregulatory subtypes reveal prognostic and therapeutic insights in multiple primary lung cancer. | Front Immunol | 2026 | 42528797 | PubTator, text mining | PubMed |
| A salivary protein panel for detecting malignant transformation of oral leukoplakia. | Oral Oncol | 2026 | 42385552 | PubTator, text mining | PubMed |
| Hypoxia Remodels the Extracellular Vesicle Proteome to Drive Metastasis in Breast Cancer via Metabolic-Epigenetic Coupling. | J Proteome Res | 2026 | 42341239 | PubTator, text mining | PubMed |
| Integrated single-cell and bulk RNA-seq analysis identifies BCAA metabolism-related prognostic signatures in head and neck squamous cell carcinoma. | Immunobiology | 2026 | 42263482 | PubTator, text mining | PubMed |
| Integrated transcriptomics, network pharmacology and clinical expression validation reveal the prognostic significance of PANoptosis-related genes in cordycepin-treated lung adenocarcinoma. | Discov Oncol | 2026 | 42260221 | PubTator, text mining | PubMed |
| Metabolic alterations in Snyder-Robinson syndrome lymphoblasts are ameliorated by phenylbutyrate treatment. | Mol Genet Metab | 2026 | 42250346 | PubTator, text mining | PubMed |
1 to 10 of 1,316
See all 1,316 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/6611
GET https://conductscience.org/api/genes/v1/6611/patents?page=2