ConductScience.org, home

Library / Genes

SNCA: synuclein alpha

1 protein, 742 patents, 2 drugs, 8 trials, 12,935 NIH grants and 44,650 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSNCAHGNC
Namesynuclein alphaHGNC
NCBI Gene ID6622NCBI Gene
HGNC IDHGNC:11138HGNC
EnsemblENSG00000145335NCBI Gene
AliasesNACP, PARK1, PARK4, PD1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P37840Alpha-synuclein140231Ensembl, GeneID, HGNCUniProt

Patents 742

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026190230 A12026-09-171P37840Espacenet
WO 2026183515 A12026-09-0312P37840Espacenet
EP 4796929 A22026-08-261P37840Espacenet
WO 2026172356 A12026-08-204P37840Espacenet
EP 4791772 A12026-08-191P37840Espacenet
EP 4793289 A22026-08-199P37840Espacenet
EP 4770680 A12026-07-0818P37840Espacenet
EP 4762079 A12026-06-241P37840Espacenet
EP 4762079 A12026-06-24439P37840Espacenet
JP 2026086794 A2026-05-261P37840Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CINPANEMABCHEMBL3833330Alpha-synuclein inhibitorINHIBITORChEMBL
PRASINEZUMABCHEMBL4298077Alpha-synuclein binding agentBINDING AGENTChEMBL

Trials 8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07174310PRASINEZUMABPHASE3ClinicalTrials.gov
NCT07055087PRASINEZUMABPHASE2ClinicalTrials.gov
NCT04777331PRASINEZUMABPHASE22025-12-02ClinicalTrials.gov
NCT03716570CINPANEMABPHASE1ClinicalTrials.gov
NCT03318523CINPANEMABPHASE22021-11-23ClinicalTrials.gov
NCT03100149PRASINEZUMABPHASE22021-02-08ClinicalTrials.gov
NCT02459886CINPANEMABPHASE1ClinicalTrials.gov
NCT02157714PRASINEZUMABPHASE1ClinicalTrials.gov

NIH grants 12935

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions922,025NIH's project files
T32AG000255Training in age related neurodegenerative diseases612,025NIH's project files
ZIAAG000936Alzheimers Disease Project: Neuroimmune responses and therapeutics of alpha-synucleinopathies of the aging population582,025NIH's project files
P40OD010440Caenorhabditis Genetics Center562,025NIH's project files
P30CA016672Cancer Center Support Grant512,025NIH's project files
P30CA008748Cancer Center Support Grant502,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity492,025NIH's project files
ZIANS003034Biomarkers of Catecholaminergic Neurodegeneration492,025NIH's project files
P30AG062677Mayo Alzheimer's Disease Research Center482,025NIH's project files
P30AG072979Penn Alzheimer's Disease Research Center (ADRC)452,025NIH's project files

Papers 44650

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827189PubTator, text miningPubMed
42826842PubTator, text miningPubMed
42826760PubTator, text miningPubMed
42825179PubTator, text miningPubMed
42823745PubTator, text miningPubMed
42823411PubTator, text miningPubMed
42822277PubTator, text miningPubMed
42821418PubTator, text miningPubMed
42820786PubTator, text miningPubMed
42818937PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license