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Gene · 6624

FSCN1: fascin actin-bundling protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FSCN1: fascin actin-bundling protein 1. Genes, record 6624. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6624

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Gene

Symbol
FSCN1
HGNC
Name
fascin actin-bundling protein 1
HGNC
NCBI Gene ID
6624
NCBI Gene
HGNC ID
HGNC:11148
HGNC
Ensembl
ENSG00000075618
NCBI Gene
Aliases
FLJ38511, HSN, SNL, p55
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16658Fascin49328Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445898Q16658Espacenet
EP 4650780 A22025-11-1910546Q16658Espacenet
EP 4641202 A22025-10-295792Q16658Espacenet
JP 2025517970 A2025-06-1210546Q16658Espacenet
KR 1020250017231 A2025-02-045792Q16658Espacenet
JP 2024510632 A2024-03-082Q16658Espacenet
JP 2023123507 A2023-09-0553Q16658Espacenet
US 11446398 B22022-09-2030797Q16658Espacenet
JP 2022524081 A2022-04-27133768Q16658Espacenet
US 11078247 B22021-08-034198Q16658Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,500

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFSCN1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant92025
P30CA076292Moffitt Cancer Center Support Grant82025
P40OD010440Caenorhabditis Genetics Center72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025
P50CA126752SPORE in Lymphoma62025
P30CA086862Cancer Center Support Grant52025
P20GM103446Delaware INBRE42025
P30CA016058Cancer Center Support Grant42025
R35GM122545The impact of dynamic actin polymerization on mitochondrial dynamics and function42025

1 to 10 of 1,500Source NIH's project files

See all 1,500 nih grants

Papers3,382

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CaMKII generates actin bundle morphology and mechanics distinct from canonical bivalent cross-linkers.bioRxiv202642817999PubTator, text miningPubMed
FSCN1 Modulates Fatty Acid Metabolism and the Coordinated Activation of AKT/mTOR and p38 MAPK Pathways in Colorectal Cancer Cells.Oncol Res202642769853PubTator, text miningPubMed
The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation.Oncogene202642693251PubTator, text miningPubMed
Fascin-Centred Invasive Competence in Eutopic Endometrium: A Hypothesis-Driven Narrative Review of Endometriosis Pathogenesis and Non-Surgical Biomarker Potential.Int J Mol Sci202642653239PubTator, text miningPubMed
Fascin in dendritic protrusions is required for synaptic plasticity.J Biol Chem202642617739PubTator, text miningPubMed
[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells.Mol Med Rep202642596825PubTator, text miningPubMed
State-dependent energy conversion produces degenerate dissipation in active actomyosin networks.bioRxiv202642395412PubTator, text miningPubMed
Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.J Cell Biol202642384037PubTator, text miningPubMed
Integrative multi-omics and single-cell analysis identifies EGFR pathway activation and metabolic reprogramming as potential synthetic lethal vulnerabilities in resistance to the FGFR inhibitor AZD4547.
J Transl Med202642351126PubTator, text miningPubMed
Fascin-1 expression in non-small cell lung cancer and its diagnostic implications.Discov Oncol202642258099PubTator, text miningPubMed

1 to 10 of 3,382

See all 3,382 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/6624

GET https://conductscience.org/api/genes/v1/6624/patents?page=2